Serum Vitamin D Status in Older Adults: A Cohort Study
Background: Vitamin D is best known as a key regulator of bone metabolism and calcium and phosphate homeostasis. This study aimed to assess the effect of different factors on the five-year changes in serum vitamin D concentration among older adults.Methods: This cohort study was conducted on adults...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2023-05-01
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| Series: | Iranian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://ijms.sums.ac.ir/article_48990_fae9e4c77511b98919be165170530e66.pdf |
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| author | Simin Mouodi Sajedeh Delbari Seyed Reza Hosseini Reza Ghadimi Ali Bijani |
| author_facet | Simin Mouodi Sajedeh Delbari Seyed Reza Hosseini Reza Ghadimi Ali Bijani |
| author_sort | Simin Mouodi |
| collection | DOAJ |
| description | Background: Vitamin D is best known as a key regulator of bone metabolism and calcium and phosphate homeostasis. This study aimed to assess the effect of different factors on the five-year changes in serum vitamin D concentration among older adults.Methods: This cohort study was conducted on adults aged ≥60 years living in Amirkola, in the North of Iran, from 2012 to 2017. Serum 25-hydroxyvitamin D (25-OH vitamin D) concentrations of <20, 20-29.99, and ≥30 ng/mL, respectively, were used to designate vitamin D deficiency, insufficiency, and sufficiency. Any variation between the second and baseline values of the 25-OH vitamin D concentration was reported as a five-year difference. Data were analyzed using SPSS version 17.0, and Chi square, t test, one-way ANOVA, and Tukey HSD post hoc tests were employed. P values less than 0.05 were considered statistically significant.Results: The mean serum concentration of 25-OH vitamin D at baseline and follow-up examination in 1011 individuals was 34.68±33.18 and 23.88±14.91, respectively (P<0.001). Following a five-year follow-up, vitamin D deficiency, insufficiency, and sufficiency were found in 452 (44.7%), 334 (33.0%), and 225 (22.3%) cases, respectively. The reduction in serum 25-OH vitamin D concentration after five years was significantly influenced by the administration of vitamin D (P=0.013) and calcium (P=0.007) supplements, serum profile of parathyroid hormone (PTH) (P=0.010), calcium (P=0.021), and phosphorous (P=0.021). However, age, sex, body mass index, metabolic syndrome, and physical activity had no significant impact (P>0.05). Conclusion: Regardless of age, sex, body mass index, metabolic syndrome, or physical activity, the mean serum concentration of vitamin D decreased over a five-year follow-up. |
| first_indexed | 2024-03-13T10:21:47Z |
| format | Article |
| id | doaj.art-5dbd2015a2ee4e42a6546f5d53622b4e |
| institution | Directory Open Access Journal |
| issn | 0253-0716 1735-3688 |
| language | English |
| last_indexed | 2024-03-13T10:21:47Z |
| publishDate | 2023-05-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Sciences |
| spelling | doaj.art-5dbd2015a2ee4e42a6546f5d53622b4e2023-05-20T05:55:54ZengShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-07161735-36882023-05-0148327728510.30476/ijms.2022.94269.255048990Serum Vitamin D Status in Older Adults: A Cohort StudySimin Mouodi0Sajedeh Delbari1Seyed Reza Hosseini2Reza Ghadimi3Ali Bijani4Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranBackground: Vitamin D is best known as a key regulator of bone metabolism and calcium and phosphate homeostasis. This study aimed to assess the effect of different factors on the five-year changes in serum vitamin D concentration among older adults.Methods: This cohort study was conducted on adults aged ≥60 years living in Amirkola, in the North of Iran, from 2012 to 2017. Serum 25-hydroxyvitamin D (25-OH vitamin D) concentrations of <20, 20-29.99, and ≥30 ng/mL, respectively, were used to designate vitamin D deficiency, insufficiency, and sufficiency. Any variation between the second and baseline values of the 25-OH vitamin D concentration was reported as a five-year difference. Data were analyzed using SPSS version 17.0, and Chi square, t test, one-way ANOVA, and Tukey HSD post hoc tests were employed. P values less than 0.05 were considered statistically significant.Results: The mean serum concentration of 25-OH vitamin D at baseline and follow-up examination in 1011 individuals was 34.68±33.18 and 23.88±14.91, respectively (P<0.001). Following a five-year follow-up, vitamin D deficiency, insufficiency, and sufficiency were found in 452 (44.7%), 334 (33.0%), and 225 (22.3%) cases, respectively. The reduction in serum 25-OH vitamin D concentration after five years was significantly influenced by the administration of vitamin D (P=0.013) and calcium (P=0.007) supplements, serum profile of parathyroid hormone (PTH) (P=0.010), calcium (P=0.021), and phosphorous (P=0.021). However, age, sex, body mass index, metabolic syndrome, and physical activity had no significant impact (P>0.05). Conclusion: Regardless of age, sex, body mass index, metabolic syndrome, or physical activity, the mean serum concentration of vitamin D decreased over a five-year follow-up.https://ijms.sums.ac.ir/article_48990_fae9e4c77511b98919be165170530e66.pdfvitamin dagingvitamin deficiency |
| spellingShingle | Simin Mouodi Sajedeh Delbari Seyed Reza Hosseini Reza Ghadimi Ali Bijani Serum Vitamin D Status in Older Adults: A Cohort Study Iranian Journal of Medical Sciences vitamin d aging vitamin deficiency |
| title | Serum Vitamin D Status in Older Adults: A Cohort Study |
| title_full | Serum Vitamin D Status in Older Adults: A Cohort Study |
| title_fullStr | Serum Vitamin D Status in Older Adults: A Cohort Study |
| title_full_unstemmed | Serum Vitamin D Status in Older Adults: A Cohort Study |
| title_short | Serum Vitamin D Status in Older Adults: A Cohort Study |
| title_sort | serum vitamin d status in older adults a cohort study |
| topic | vitamin d aging vitamin deficiency |
| url | https://ijms.sums.ac.ir/article_48990_fae9e4c77511b98919be165170530e66.pdf |
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