Antihistamines considerably modulate the cognitive and psychomotor performance of human volunteers
This research investigated the modulating effects of antihistamines—Loratadine, Fexofenadine, Meclizine, and Chlorpheniramine on cognitive (executive function, memory, attention, emotion regulation), mood, psychomotor performance, and sedation in healthy human volunteers. Twenty healthy volunteers r...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2016-12-01
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| Series: | Cogent Psychology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23311908.2016.1216242 |
| _version_ | 1818336985832488960 |
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| author | Rawshan Zannat Mir Muhammad Nasir Uddin Md. Atiar Rahman Jannatul Aklima Md. Mamun Al Amin |
| author_facet | Rawshan Zannat Mir Muhammad Nasir Uddin Md. Atiar Rahman Jannatul Aklima Md. Mamun Al Amin |
| author_sort | Rawshan Zannat |
| collection | DOAJ |
| description | This research investigated the modulating effects of antihistamines—Loratadine, Fexofenadine, Meclizine, and Chlorpheniramine on cognitive (executive function, memory, attention, emotion regulation), mood, psychomotor performance, and sedation in healthy human volunteers. Twenty healthy volunteers received Loratadine 10-mg, Fexofenadine 120-mg, Meclizine 50-mg, Chlorpheniramine Maleate 4-mg, and Placebo 250-mg starch tablet in a five-way crossover, double-blind study. Following each dose the participants were subjected to take a series of test of cognitive functions and psychomotor performances at defined interval. A certain amount of washout period was also maintained for each drug. The test battery included PennCNP—Full Battery Test, Psychology Experiment Building Language, Stanford Sleepiness Scale, and Brief Mood Introspection Scale. The test results These test results were analyzed by one-way and two-way ANOVAs. In general, antihistamines didn't show any statistically significant deviation from that of placebo. However, slight improvement was observed in word memory test (Both immediate and delayed) by Chlorpheniramine; although it increased the reaction time in visual object learning test. Fexofenadine also increased performance in delayed word memory test. Meclizine showed significant reduction (p < 0.05) of reaction time in line orientation task. The subjects receiving Loratadine reported slightly unpleasant mood then control group. This study will contribute to choose antihistamine rightly maximizing the productivity; minimizing the losses of working hours and daytime in school and workplaces. Right options of antihistamines will make wider flexibility for the people needed sharp motor functioning to work in factory with life-threatening machineries achieving less sedation and psychomotor unimpairment. |
| first_indexed | 2024-12-13T14:48:01Z |
| format | Article |
| id | doaj.art-5dbdda865a5e4bdb951b22d0faa3b0fe |
| institution | Directory Open Access Journal |
| issn | 2331-1908 |
| language | English |
| last_indexed | 2024-12-13T14:48:01Z |
| publishDate | 2016-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cogent Psychology |
| spelling | doaj.art-5dbdda865a5e4bdb951b22d0faa3b0fe2022-12-21T23:41:25ZengTaylor & Francis GroupCogent Psychology2331-19082016-12-013110.1080/23311908.2016.12162421216242Antihistamines considerably modulate the cognitive and psychomotor performance of human volunteersRawshan Zannat0Mir Muhammad Nasir Uddin1Md. Atiar Rahman2Jannatul Aklima3Md. Mamun Al Amin4University of ChittagongUniversity of ChittagongUniversity of ChittagongUniversity of ChittagongUniversity of QueenslandThis research investigated the modulating effects of antihistamines—Loratadine, Fexofenadine, Meclizine, and Chlorpheniramine on cognitive (executive function, memory, attention, emotion regulation), mood, psychomotor performance, and sedation in healthy human volunteers. Twenty healthy volunteers received Loratadine 10-mg, Fexofenadine 120-mg, Meclizine 50-mg, Chlorpheniramine Maleate 4-mg, and Placebo 250-mg starch tablet in a five-way crossover, double-blind study. Following each dose the participants were subjected to take a series of test of cognitive functions and psychomotor performances at defined interval. A certain amount of washout period was also maintained for each drug. The test battery included PennCNP—Full Battery Test, Psychology Experiment Building Language, Stanford Sleepiness Scale, and Brief Mood Introspection Scale. The test results These test results were analyzed by one-way and two-way ANOVAs. In general, antihistamines didn't show any statistically significant deviation from that of placebo. However, slight improvement was observed in word memory test (Both immediate and delayed) by Chlorpheniramine; although it increased the reaction time in visual object learning test. Fexofenadine also increased performance in delayed word memory test. Meclizine showed significant reduction (p < 0.05) of reaction time in line orientation task. The subjects receiving Loratadine reported slightly unpleasant mood then control group. This study will contribute to choose antihistamine rightly maximizing the productivity; minimizing the losses of working hours and daytime in school and workplaces. Right options of antihistamines will make wider flexibility for the people needed sharp motor functioning to work in factory with life-threatening machineries achieving less sedation and psychomotor unimpairment.http://dx.doi.org/10.1080/23311908.2016.1216242antihistaminecognitive performancepsychomotor performancemoodsleep |
| spellingShingle | Rawshan Zannat Mir Muhammad Nasir Uddin Md. Atiar Rahman Jannatul Aklima Md. Mamun Al Amin Antihistamines considerably modulate the cognitive and psychomotor performance of human volunteers Cogent Psychology antihistamine cognitive performance psychomotor performance mood sleep |
| title | Antihistamines considerably modulate the cognitive and psychomotor performance of human volunteers |
| title_full | Antihistamines considerably modulate the cognitive and psychomotor performance of human volunteers |
| title_fullStr | Antihistamines considerably modulate the cognitive and psychomotor performance of human volunteers |
| title_full_unstemmed | Antihistamines considerably modulate the cognitive and psychomotor performance of human volunteers |
| title_short | Antihistamines considerably modulate the cognitive and psychomotor performance of human volunteers |
| title_sort | antihistamines considerably modulate the cognitive and psychomotor performance of human volunteers |
| topic | antihistamine cognitive performance psychomotor performance mood sleep |
| url | http://dx.doi.org/10.1080/23311908.2016.1216242 |
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