3D biofabrication of diseased human skin models in vitro
Abstract Human skin is an organ located in the outermost part of the body; thus, it frequently exhibits visible signs of physiological health. Ethical concerns and genetic differences in conventional animal studies have increased the need for alternative in vitro platforms that mimic the structural...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2023-08-01
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| Series: | Biomaterials Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40824-023-00415-5 |
| _version_ | 1797282828091654144 |
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| author | Minjun Ahn Won-Woo Cho Wonbin Park Jae-Seong Lee Min-Ju Choi Qiqi Gao Ge Gao Dong-Woo Cho Byoung Soo Kim |
| author_facet | Minjun Ahn Won-Woo Cho Wonbin Park Jae-Seong Lee Min-Ju Choi Qiqi Gao Ge Gao Dong-Woo Cho Byoung Soo Kim |
| author_sort | Minjun Ahn |
| collection | DOAJ |
| description | Abstract Human skin is an organ located in the outermost part of the body; thus, it frequently exhibits visible signs of physiological health. Ethical concerns and genetic differences in conventional animal studies have increased the need for alternative in vitro platforms that mimic the structural and functional hallmarks of natural skin. Despite significant advances in in vitro skin modeling over the past few decades, different reproducible biofabrication strategies are required to reproduce the pathological features of diseased human skin compared to those used for healthy-skin models. To explain human skin modeling with pathological hallmarks, we first summarize the structural and functional characteristics of healthy human skin. We then provide an extensive overview of how to recreate diseased human skin models in vitro, including models for wounded, diabetic, skin-cancer, atopic, and other pathological skin types. We conclude with an outlook on diseased-skin modeling and its technical perspective for the further development of skin engineering. |
| first_indexed | 2024-03-07T17:20:03Z |
| format | Article |
| id | doaj.art-5dbe75ed197b42429dbb7a20263ea8d9 |
| institution | Directory Open Access Journal |
| issn | 2055-7124 |
| language | English |
| last_indexed | 2024-03-07T17:20:03Z |
| publishDate | 2023-08-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Biomaterials Research |
| spelling | doaj.art-5dbe75ed197b42429dbb7a20263ea8d92024-03-02T20:32:28ZengAmerican Association for the Advancement of Science (AAAS)Biomaterials Research2055-71242023-08-0127111310.1186/s40824-023-00415-53D biofabrication of diseased human skin models in vitroMinjun Ahn0Won-Woo Cho1Wonbin Park2Jae-Seong Lee3Min-Ju Choi4Qiqi Gao5Ge Gao6Dong-Woo Cho7Byoung Soo Kim8Medical Research Institute, Pusan National UniversityDepartment of Mechanical Engineering, Pohang University of Science and TechnologyDepartment of Mechanical Engineering, Pohang University of Science and TechnologySchool of Biomedical Convergence Engineering, Pusan National UniversitySchool of Biomedical Convergence Engineering, Pusan National UniversitySchool of Medical Engineering, Beijing Institute of TechnologySchool of Medical Engineering, Beijing Institute of TechnologyDepartment of Mechanical Engineering, Pohang University of Science and TechnologyMedical Research Institute, Pusan National UniversityAbstract Human skin is an organ located in the outermost part of the body; thus, it frequently exhibits visible signs of physiological health. Ethical concerns and genetic differences in conventional animal studies have increased the need for alternative in vitro platforms that mimic the structural and functional hallmarks of natural skin. Despite significant advances in in vitro skin modeling over the past few decades, different reproducible biofabrication strategies are required to reproduce the pathological features of diseased human skin compared to those used for healthy-skin models. To explain human skin modeling with pathological hallmarks, we first summarize the structural and functional characteristics of healthy human skin. We then provide an extensive overview of how to recreate diseased human skin models in vitro, including models for wounded, diabetic, skin-cancer, atopic, and other pathological skin types. We conclude with an outlook on diseased-skin modeling and its technical perspective for the further development of skin engineering.https://doi.org/10.1186/s40824-023-00415-5Skin engineeringDiseased-skin modelTissue engineeringIn vitro modeling |
| spellingShingle | Minjun Ahn Won-Woo Cho Wonbin Park Jae-Seong Lee Min-Ju Choi Qiqi Gao Ge Gao Dong-Woo Cho Byoung Soo Kim 3D biofabrication of diseased human skin models in vitro Biomaterials Research Skin engineering Diseased-skin model Tissue engineering In vitro modeling |
| title | 3D biofabrication of diseased human skin models in vitro |
| title_full | 3D biofabrication of diseased human skin models in vitro |
| title_fullStr | 3D biofabrication of diseased human skin models in vitro |
| title_full_unstemmed | 3D biofabrication of diseased human skin models in vitro |
| title_short | 3D biofabrication of diseased human skin models in vitro |
| title_sort | 3d biofabrication of diseased human skin models in vitro |
| topic | Skin engineering Diseased-skin model Tissue engineering In vitro modeling |
| url | https://doi.org/10.1186/s40824-023-00415-5 |
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