Way to efficient microbial paclitaxel mass production
The microbial synthesis of paclitaxel is attractive for its short-cycle, cost-effectiveness, and sustainability. However, low paclitaxel productivity, depleted capacity during subculture and storage, and unclear biosynthesis mechanisms restrain industrial microbial synthesis. Along with the isolatio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2023-12-01
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| Series: | Synthetic and Systems Biotechnology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405805X23000844 |
| _version_ | 1827265227568185344 |
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| author | Chenyue Li Yanli Qi Zhongke Sun Mengwan Jiang Chengwei Li |
| author_facet | Chenyue Li Yanli Qi Zhongke Sun Mengwan Jiang Chengwei Li |
| author_sort | Chenyue Li |
| collection | DOAJ |
| description | The microbial synthesis of paclitaxel is attractive for its short-cycle, cost-effectiveness, and sustainability. However, low paclitaxel productivity, depleted capacity during subculture and storage, and unclear biosynthesis mechanisms restrain industrial microbial synthesis. Along with the isolation of various paclitaxel-producing microorganisms and the development of versatile molecular tools, tremendous promises for microbial paclitaxel synthesis have become increasingly prominent. In this review, we summarize the progress of microbial synthesis of paclitaxel in recent years, focusing on paclitaxel-producing endophytes and representative engineering microorganism hosts that were used as chassis for paclitaxel precursor synthesis. Numerous wide-type microbes can manufacture paclitaxel, and fermentation process optimization and strain improvement can greatly enhance the productivity. Engineered microbes can efficiently synthesize precursors of paclitaxel by introducing exogenous synthetic pathway. Mining paclitaxel synthetic pathways and genetic manipulation of endophytes will accelerate the construction of microbial cell factories, indefinitely contributing to paclitaxel mass production by microbes. This review emphasizes the potential and provides solutions for efficient microbial paclitaxel mass production. |
| first_indexed | 2024-03-08T18:42:52Z |
| format | Article |
| id | doaj.art-5dc33aad99454627a1577d63c91abbca |
| institution | Directory Open Access Journal |
| issn | 2405-805X |
| language | English |
| last_indexed | 2025-03-22T03:58:36Z |
| publishDate | 2023-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Synthetic and Systems Biotechnology |
| spelling | doaj.art-5dc33aad99454627a1577d63c91abbca2024-04-28T10:45:38ZengKeAi Communications Co., Ltd.Synthetic and Systems Biotechnology2405-805X2023-12-0184673681Way to efficient microbial paclitaxel mass productionChenyue Li0Yanli Qi1Zhongke Sun2Mengwan Jiang3Chengwei Li4School of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, ChinaSchool of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, China; Corresponding author.School of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, China; Nanyang Institute of Medical Plant Technology and Industry, Nanyang, 473005, ChinaSchool of Artificial Intelligence and Big Data, Henan University of Technology, Zhengzhou, 450001, ChinaSchool of Biological Engineering, Henan University of Technology, Zhengzhou, 450001, China; Corresponding author. No. 100, Lianhua Road, Gaoxin District, Zhengzhou City, Henan Province, 450001, China.The microbial synthesis of paclitaxel is attractive for its short-cycle, cost-effectiveness, and sustainability. However, low paclitaxel productivity, depleted capacity during subculture and storage, and unclear biosynthesis mechanisms restrain industrial microbial synthesis. Along with the isolation of various paclitaxel-producing microorganisms and the development of versatile molecular tools, tremendous promises for microbial paclitaxel synthesis have become increasingly prominent. In this review, we summarize the progress of microbial synthesis of paclitaxel in recent years, focusing on paclitaxel-producing endophytes and representative engineering microorganism hosts that were used as chassis for paclitaxel precursor synthesis. Numerous wide-type microbes can manufacture paclitaxel, and fermentation process optimization and strain improvement can greatly enhance the productivity. Engineered microbes can efficiently synthesize precursors of paclitaxel by introducing exogenous synthetic pathway. Mining paclitaxel synthetic pathways and genetic manipulation of endophytes will accelerate the construction of microbial cell factories, indefinitely contributing to paclitaxel mass production by microbes. This review emphasizes the potential and provides solutions for efficient microbial paclitaxel mass production.http://www.sciencedirect.com/science/article/pii/S2405805X23000844PaclitaxelMicrobial fermentationEndophytesProcess optimizationSynthetic pathway |
| spellingShingle | Chenyue Li Yanli Qi Zhongke Sun Mengwan Jiang Chengwei Li Way to efficient microbial paclitaxel mass production Synthetic and Systems Biotechnology Paclitaxel Microbial fermentation Endophytes Process optimization Synthetic pathway |
| title | Way to efficient microbial paclitaxel mass production |
| title_full | Way to efficient microbial paclitaxel mass production |
| title_fullStr | Way to efficient microbial paclitaxel mass production |
| title_full_unstemmed | Way to efficient microbial paclitaxel mass production |
| title_short | Way to efficient microbial paclitaxel mass production |
| title_sort | way to efficient microbial paclitaxel mass production |
| topic | Paclitaxel Microbial fermentation Endophytes Process optimization Synthetic pathway |
| url | http://www.sciencedirect.com/science/article/pii/S2405805X23000844 |
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