Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy
For decades, chronic diseases including cardiovascular and cerebrovascular diseases (CCVDs) have plagued the world. Meanwhile, we have noticed a close association between CCVDs and vascular lesions, such as hypertension. More focus has been placed on TMPs and natural products with vasodilation and h...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-04-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.627458/full |
| _version_ | 1818350051217375232 |
|---|---|
| author | Fei Tang Hong-Ling Yan Li-Xia Wang Jin-Feng Xu Cheng Peng Hui Ao Yu-Zhu Tan |
| author_facet | Fei Tang Hong-Ling Yan Li-Xia Wang Jin-Feng Xu Cheng Peng Hui Ao Yu-Zhu Tan |
| author_sort | Fei Tang |
| collection | DOAJ |
| description | For decades, chronic diseases including cardiovascular and cerebrovascular diseases (CCVDs) have plagued the world. Meanwhile, we have noticed a close association between CCVDs and vascular lesions, such as hypertension. More focus has been placed on TMPs and natural products with vasodilation and hypotension. TMPs with vasodilatory and hypotensive activities are mainly from Compositae, Lamiaceae, and Orchidaceae (such as V. amygdalina Del., T. procuinbens L., M. glomerata Spreng., K. galanga L., etc.) whereas natural products eliciting vasorelaxant potentials were primarily from flavonoids, phenolic acids and alkaloids (such as apigenin, puerarin, curcumin, sinomenine, etc.). Furthermore, the data analysis showed that the vasodilatory function of TMPs was mainly concerned with the activation of eNOS, while the natural products were primarily correlated with the blockage of calcium channel. Thus, TMPs will be used as alternative drugs and nutritional supplements, while natural products will be considered as potential therapies for CCVDs in the future. This study provides comprehensive and valuable references for the prevention and treatment of hypertension and CCVDs and sheds light on the further studies in this regard. However, since most studies are in vitro and preclinical, there is a need for more in-depth researches and clinical trials to understand the potential of these substances. |
| first_indexed | 2024-12-13T18:15:42Z |
| format | Article |
| id | doaj.art-5dc4c2e18127404cad9f2ca61ef91e56 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-13T18:15:42Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-5dc4c2e18127404cad9f2ca61ef91e562022-12-21T23:35:51ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-04-011210.3389/fphar.2021.627458627458Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical EfficacyFei Tang0Hong-Ling Yan1Li-Xia Wang2Jin-Feng Xu3Cheng Peng4Hui Ao5Yu-Zhu Tan6State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaInnovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaState Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaFor decades, chronic diseases including cardiovascular and cerebrovascular diseases (CCVDs) have plagued the world. Meanwhile, we have noticed a close association between CCVDs and vascular lesions, such as hypertension. More focus has been placed on TMPs and natural products with vasodilation and hypotension. TMPs with vasodilatory and hypotensive activities are mainly from Compositae, Lamiaceae, and Orchidaceae (such as V. amygdalina Del., T. procuinbens L., M. glomerata Spreng., K. galanga L., etc.) whereas natural products eliciting vasorelaxant potentials were primarily from flavonoids, phenolic acids and alkaloids (such as apigenin, puerarin, curcumin, sinomenine, etc.). Furthermore, the data analysis showed that the vasodilatory function of TMPs was mainly concerned with the activation of eNOS, while the natural products were primarily correlated with the blockage of calcium channel. Thus, TMPs will be used as alternative drugs and nutritional supplements, while natural products will be considered as potential therapies for CCVDs in the future. This study provides comprehensive and valuable references for the prevention and treatment of hypertension and CCVDs and sheds light on the further studies in this regard. However, since most studies are in vitro and preclinical, there is a need for more in-depth researches and clinical trials to understand the potential of these substances.https://www.frontiersin.org/articles/10.3389/fphar.2021.627458/fulltraditional medicinal plantsnatural productsvasodilationmechanismcardiovascular and cerebrovascular diseases |
| spellingShingle | Fei Tang Hong-Ling Yan Li-Xia Wang Jin-Feng Xu Cheng Peng Hui Ao Yu-Zhu Tan Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy Frontiers in Pharmacology traditional medicinal plants natural products vasodilation mechanism cardiovascular and cerebrovascular diseases |
| title | Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy |
| title_full | Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy |
| title_fullStr | Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy |
| title_full_unstemmed | Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy |
| title_short | Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy |
| title_sort | review of natural resources with vasodilation traditional medicinal plants natural products and their mechanism and clinical efficacy |
| topic | traditional medicinal plants natural products vasodilation mechanism cardiovascular and cerebrovascular diseases |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.627458/full |
| work_keys_str_mv | AT feitang reviewofnaturalresourceswithvasodilationtraditionalmedicinalplantsnaturalproductsandtheirmechanismandclinicalefficacy AT honglingyan reviewofnaturalresourceswithvasodilationtraditionalmedicinalplantsnaturalproductsandtheirmechanismandclinicalefficacy AT lixiawang reviewofnaturalresourceswithvasodilationtraditionalmedicinalplantsnaturalproductsandtheirmechanismandclinicalefficacy AT jinfengxu reviewofnaturalresourceswithvasodilationtraditionalmedicinalplantsnaturalproductsandtheirmechanismandclinicalefficacy AT chengpeng reviewofnaturalresourceswithvasodilationtraditionalmedicinalplantsnaturalproductsandtheirmechanismandclinicalefficacy AT huiao reviewofnaturalresourceswithvasodilationtraditionalmedicinalplantsnaturalproductsandtheirmechanismandclinicalefficacy AT yuzhutan reviewofnaturalresourceswithvasodilationtraditionalmedicinalplantsnaturalproductsandtheirmechanismandclinicalefficacy |