Broccoli Improves Lipid Metabolism and Intestinal Flora in Mice with Type 2 Diabetes Induced by HFD and STZ Diet
Globally, type 2 diabetes (T2DM) is on the rise. Maintaining a healthy diet is crucial for both treating and preventing T2DM.As a common vegetable in daily diet, broccoli has antioxidant, anti-inflammatory and anticarcoma physiological activities. We developed a mouse model of type 2 diabetes and ca...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/13/2/273 |
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| author | Xin Li Zifan Cai Feiyu Yang Yunfan Wang Xinyi Pang Jing Sun Xiangfei Li Yingjian Lu |
| author_facet | Xin Li Zifan Cai Feiyu Yang Yunfan Wang Xinyi Pang Jing Sun Xiangfei Li Yingjian Lu |
| author_sort | Xin Li |
| collection | DOAJ |
| description | Globally, type 2 diabetes (T2DM) is on the rise. Maintaining a healthy diet is crucial for both treating and preventing T2DM.As a common vegetable in daily diet, broccoli has antioxidant, anti-inflammatory and anticarcoma physiological activities. We developed a mouse model of type 2 diabetes and carried out a systematic investigation to clarify the function of broccoli in reducing T2DM symptoms and controlling intestinal flora. The findings demonstrated that broccoli could successfully lower fasting blood glucose (FBG), lessen insulin resistance, regulate lipid metabolism, lower the levels of TC, TG, LDL-C, and MDA, stop the expression of IL-1β and IL-6, and decrease the harm that diabetes causes to the pancreas, liver, fat, and other organs and tissues. Furthermore, broccoli altered the intestinal flora’s makeup in mice with T2DM. At the genus level, the relative abundance of <i>Allobaculum</i> decreased, and that of <i>Odoribacter</i> and <i>Oscillospira</i> increased; At the family level, the relative abundances of Odoribacteraceae, Rikenellaceae and S24-7 decreased, while the relative abundances of Erysipelotrichaceae and Rikenellaceae increased. |
| first_indexed | 2024-03-08T09:54:49Z |
| format | Article |
| id | doaj.art-5dc4fbc663dd42cf9b1491db18e8fdd9 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-08T09:54:49Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-5dc4fbc663dd42cf9b1491db18e8fdd92024-01-29T13:52:21ZengMDPI AGFoods2304-81582024-01-0113227310.3390/foods13020273Broccoli Improves Lipid Metabolism and Intestinal Flora in Mice with Type 2 Diabetes Induced by HFD and STZ DietXin Li0Zifan Cai1Feiyu Yang2Yunfan Wang3Xinyi Pang4Jing Sun5Xiangfei Li6Yingjian Lu7College of Food Science and Engineering, Nanjing University of Finance and Economics, Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics, Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaCollege of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics, Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics, Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics, Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics, Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaCollege of Food Science and Engineering, Nanjing University of Finance and Economics, Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, ChinaGlobally, type 2 diabetes (T2DM) is on the rise. Maintaining a healthy diet is crucial for both treating and preventing T2DM.As a common vegetable in daily diet, broccoli has antioxidant, anti-inflammatory and anticarcoma physiological activities. We developed a mouse model of type 2 diabetes and carried out a systematic investigation to clarify the function of broccoli in reducing T2DM symptoms and controlling intestinal flora. The findings demonstrated that broccoli could successfully lower fasting blood glucose (FBG), lessen insulin resistance, regulate lipid metabolism, lower the levels of TC, TG, LDL-C, and MDA, stop the expression of IL-1β and IL-6, and decrease the harm that diabetes causes to the pancreas, liver, fat, and other organs and tissues. Furthermore, broccoli altered the intestinal flora’s makeup in mice with T2DM. At the genus level, the relative abundance of <i>Allobaculum</i> decreased, and that of <i>Odoribacter</i> and <i>Oscillospira</i> increased; At the family level, the relative abundances of Odoribacteraceae, Rikenellaceae and S24-7 decreased, while the relative abundances of Erysipelotrichaceae and Rikenellaceae increased.https://www.mdpi.com/2304-8158/13/2/273type 2 diabetes mellitusinsulin sensitivityinflammation factorsSCFAsintestinal flora |
| spellingShingle | Xin Li Zifan Cai Feiyu Yang Yunfan Wang Xinyi Pang Jing Sun Xiangfei Li Yingjian Lu Broccoli Improves Lipid Metabolism and Intestinal Flora in Mice with Type 2 Diabetes Induced by HFD and STZ Diet Foods type 2 diabetes mellitus insulin sensitivity inflammation factors SCFAs intestinal flora |
| title | Broccoli Improves Lipid Metabolism and Intestinal Flora in Mice with Type 2 Diabetes Induced by HFD and STZ Diet |
| title_full | Broccoli Improves Lipid Metabolism and Intestinal Flora in Mice with Type 2 Diabetes Induced by HFD and STZ Diet |
| title_fullStr | Broccoli Improves Lipid Metabolism and Intestinal Flora in Mice with Type 2 Diabetes Induced by HFD and STZ Diet |
| title_full_unstemmed | Broccoli Improves Lipid Metabolism and Intestinal Flora in Mice with Type 2 Diabetes Induced by HFD and STZ Diet |
| title_short | Broccoli Improves Lipid Metabolism and Intestinal Flora in Mice with Type 2 Diabetes Induced by HFD and STZ Diet |
| title_sort | broccoli improves lipid metabolism and intestinal flora in mice with type 2 diabetes induced by hfd and stz diet |
| topic | type 2 diabetes mellitus insulin sensitivity inflammation factors SCFAs intestinal flora |
| url | https://www.mdpi.com/2304-8158/13/2/273 |
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