Amelioration of Obesity in Mice Fed a High-Fat Diet with Uronic Acid–Rich Polysaccharides Derived from <i>Tremella fuciformis</i>
Obesity is rapidly becoming an emerging disease in developing countries due to the Westernization of societies and lifestyle changes. This study evaluated the ameliorative effect of acidic heteropolysaccharides derived from <i>Tremella fuciformis</i> (TFPS) on high-fat diet (HFD; 34.9% f...
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MDPI AG
2022-04-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/8/1514 |
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| author | Chun-Hui Chiu Kai-Chu Chiu Li-Chan Yang |
| author_facet | Chun-Hui Chiu Kai-Chu Chiu Li-Chan Yang |
| author_sort | Chun-Hui Chiu |
| collection | DOAJ |
| description | Obesity is rapidly becoming an emerging disease in developing countries due to the Westernization of societies and lifestyle changes. This study evaluated the ameliorative effect of acidic heteropolysaccharides derived from <i>Tremella fuciformis</i> (TFPS) on high-fat diet (HFD; 34.9% fat)-induced obesity in mice. The TFPS exhibited high uronic acid content and high viscosity in water. The structural characteristics of TFPS showed that average molecular weight was 679 kDa, and the monosaccharide composition was galactose, glucose, fructose, xylose, fucose, and mannose at a ratio of 1.0:6.5:10.0:18.5:30.5:67.5. In an in vivo study, HFD-induced obese C57BL/6 mice were orally given a TFPS treatment at 1 and 2 g/kg of body weight for 8 weeks. The TFPS treatment significantly reduced features of obesity in the mice, namely weight gain, feed efficiency, body fat percentage, and serum cholesterol level and increased fecal lipid content, compared with mice fed an HFD with water. In addition, TFPS exhibited the inhibition of cholesterol micelles in vitro in a concentration-dependent manner. In conclusion, the TFPS treatment ameliorated the diet-induced obesity in the mice, presumably reducing fat absorption in the intestine by interfering with viscous TFPS. |
| first_indexed | 2024-03-09T13:06:35Z |
| format | Article |
| id | doaj.art-5dc52e2e3ea4466aac9401cb6c832bad |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T13:06:35Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-5dc52e2e3ea4466aac9401cb6c832bad2023-11-30T21:47:03ZengMDPI AGPolymers2073-43602022-04-01148151410.3390/polym14081514Amelioration of Obesity in Mice Fed a High-Fat Diet with Uronic Acid–Rich Polysaccharides Derived from <i>Tremella fuciformis</i>Chun-Hui Chiu0Kai-Chu Chiu1Li-Chan Yang2Graduate Institute of Health Industry and Technology, Research Center for Chinese Herbal Medicine and Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan City 333, TaiwanMaster Program for Pharmaceutical Manufacture, China Medical University, Taichung 406, TaiwanDepartment of Pharmacy, School of Pharmacy, China Medical University, Taichung 406, TaiwanObesity is rapidly becoming an emerging disease in developing countries due to the Westernization of societies and lifestyle changes. This study evaluated the ameliorative effect of acidic heteropolysaccharides derived from <i>Tremella fuciformis</i> (TFPS) on high-fat diet (HFD; 34.9% fat)-induced obesity in mice. The TFPS exhibited high uronic acid content and high viscosity in water. The structural characteristics of TFPS showed that average molecular weight was 679 kDa, and the monosaccharide composition was galactose, glucose, fructose, xylose, fucose, and mannose at a ratio of 1.0:6.5:10.0:18.5:30.5:67.5. In an in vivo study, HFD-induced obese C57BL/6 mice were orally given a TFPS treatment at 1 and 2 g/kg of body weight for 8 weeks. The TFPS treatment significantly reduced features of obesity in the mice, namely weight gain, feed efficiency, body fat percentage, and serum cholesterol level and increased fecal lipid content, compared with mice fed an HFD with water. In addition, TFPS exhibited the inhibition of cholesterol micelles in vitro in a concentration-dependent manner. In conclusion, the TFPS treatment ameliorated the diet-induced obesity in the mice, presumably reducing fat absorption in the intestine by interfering with viscous TFPS.https://www.mdpi.com/2073-4360/14/8/1514high-fat dietobesitypolysaccharide<i>Tremella fuciformis</i>uronic acidviscosity |
| spellingShingle | Chun-Hui Chiu Kai-Chu Chiu Li-Chan Yang Amelioration of Obesity in Mice Fed a High-Fat Diet with Uronic Acid–Rich Polysaccharides Derived from <i>Tremella fuciformis</i> Polymers high-fat diet obesity polysaccharide <i>Tremella fuciformis</i> uronic acid viscosity |
| title | Amelioration of Obesity in Mice Fed a High-Fat Diet with Uronic Acid–Rich Polysaccharides Derived from <i>Tremella fuciformis</i> |
| title_full | Amelioration of Obesity in Mice Fed a High-Fat Diet with Uronic Acid–Rich Polysaccharides Derived from <i>Tremella fuciformis</i> |
| title_fullStr | Amelioration of Obesity in Mice Fed a High-Fat Diet with Uronic Acid–Rich Polysaccharides Derived from <i>Tremella fuciformis</i> |
| title_full_unstemmed | Amelioration of Obesity in Mice Fed a High-Fat Diet with Uronic Acid–Rich Polysaccharides Derived from <i>Tremella fuciformis</i> |
| title_short | Amelioration of Obesity in Mice Fed a High-Fat Diet with Uronic Acid–Rich Polysaccharides Derived from <i>Tremella fuciformis</i> |
| title_sort | amelioration of obesity in mice fed a high fat diet with uronic acid rich polysaccharides derived from i tremella fuciformis i |
| topic | high-fat diet obesity polysaccharide <i>Tremella fuciformis</i> uronic acid viscosity |
| url | https://www.mdpi.com/2073-4360/14/8/1514 |
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