The Arabidopsis Sin3-HDAC Complex Facilitates Temporal Histone Deacetylation at the CCA1 and PRR9 Loci for Robust Circadian Oscillation
The circadian clock synchronizes endogenous rhythmic processes with environmental cycles and maximizes plant fitness. Multiple regulatory layers shape circadian oscillation, and chromatin modification is emerging as an important scheme for precise circadian waveforms. Here, we report the role of an...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Plant Science |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpls.2019.00171/full |
| _version_ | 1818084228313645056 |
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| author | Hong Gil Lee Cheljong Hong Pil Joon Seo Pil Joon Seo |
| author_facet | Hong Gil Lee Cheljong Hong Pil Joon Seo Pil Joon Seo |
| author_sort | Hong Gil Lee |
| collection | DOAJ |
| description | The circadian clock synchronizes endogenous rhythmic processes with environmental cycles and maximizes plant fitness. Multiple regulatory layers shape circadian oscillation, and chromatin modification is emerging as an important scheme for precise circadian waveforms. Here, we report the role of an evolutionarily conserved Sin3-histone deacetylase complex (HDAC) in circadian oscillation in Arabidopsis. SAP30 FUNCTION-RELATED 1 (AFR1) and AFR2, which are key components of Sin3-HDAC complex, are circadianly-regulated and possibly facilitate the temporal formation of the Arabidopsis Sin3-HDAC complex at dusk. The evening-expressed AFR proteins bind directly to the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and PSEUDO-RESPONSE REGULATOR 9 (PRR9) promoters and catalyze histone 3 (H3) deacetylation at the cognate regions to repress expression, allowing the declining phase of their expression at dusk. In support, the CCA1 and PRR9 genes were de-repressed around dusk in the afr1-1afr2-1 double mutant. These findings indicate that periodic histone deacetylation at the morning genes by the Sin3-HDAC complex contributes to robust circadian maintenance in higher plants. |
| first_indexed | 2024-12-10T19:50:33Z |
| format | Article |
| id | doaj.art-5dc60f652dde476fa477b7258155c750 |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-10T19:50:33Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-5dc60f652dde476fa477b7258155c7502022-12-22T01:35:48ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2019-02-011010.3389/fpls.2019.00171433484The Arabidopsis Sin3-HDAC Complex Facilitates Temporal Histone Deacetylation at the CCA1 and PRR9 Loci for Robust Circadian OscillationHong Gil Lee0Cheljong Hong1Pil Joon Seo2Pil Joon Seo3Department of Chemistry, Seoul National University, Seoul, South KoreaDepartment of Chemistry, Seoul National University, Seoul, South KoreaDepartment of Chemistry, Seoul National University, Seoul, South KoreaPlant Genomics and Breeding Institute, Seoul National University, Seoul, South KoreaThe circadian clock synchronizes endogenous rhythmic processes with environmental cycles and maximizes plant fitness. Multiple regulatory layers shape circadian oscillation, and chromatin modification is emerging as an important scheme for precise circadian waveforms. Here, we report the role of an evolutionarily conserved Sin3-histone deacetylase complex (HDAC) in circadian oscillation in Arabidopsis. SAP30 FUNCTION-RELATED 1 (AFR1) and AFR2, which are key components of Sin3-HDAC complex, are circadianly-regulated and possibly facilitate the temporal formation of the Arabidopsis Sin3-HDAC complex at dusk. The evening-expressed AFR proteins bind directly to the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and PSEUDO-RESPONSE REGULATOR 9 (PRR9) promoters and catalyze histone 3 (H3) deacetylation at the cognate regions to repress expression, allowing the declining phase of their expression at dusk. In support, the CCA1 and PRR9 genes were de-repressed around dusk in the afr1-1afr2-1 double mutant. These findings indicate that periodic histone deacetylation at the morning genes by the Sin3-HDAC complex contributes to robust circadian maintenance in higher plants.https://www.frontiersin.org/article/10.3389/fpls.2019.00171/fullcircadian clockchromatin modificationhistone deacetylase (HDAC)Sin3 histone deacetylase and corepressor complexCCA1PRR9 |
| spellingShingle | Hong Gil Lee Cheljong Hong Pil Joon Seo Pil Joon Seo The Arabidopsis Sin3-HDAC Complex Facilitates Temporal Histone Deacetylation at the CCA1 and PRR9 Loci for Robust Circadian Oscillation Frontiers in Plant Science circadian clock chromatin modification histone deacetylase (HDAC) Sin3 histone deacetylase and corepressor complex CCA1 PRR9 |
| title | The Arabidopsis Sin3-HDAC Complex Facilitates Temporal Histone Deacetylation at the CCA1 and PRR9 Loci for Robust Circadian Oscillation |
| title_full | The Arabidopsis Sin3-HDAC Complex Facilitates Temporal Histone Deacetylation at the CCA1 and PRR9 Loci for Robust Circadian Oscillation |
| title_fullStr | The Arabidopsis Sin3-HDAC Complex Facilitates Temporal Histone Deacetylation at the CCA1 and PRR9 Loci for Robust Circadian Oscillation |
| title_full_unstemmed | The Arabidopsis Sin3-HDAC Complex Facilitates Temporal Histone Deacetylation at the CCA1 and PRR9 Loci for Robust Circadian Oscillation |
| title_short | The Arabidopsis Sin3-HDAC Complex Facilitates Temporal Histone Deacetylation at the CCA1 and PRR9 Loci for Robust Circadian Oscillation |
| title_sort | arabidopsis sin3 hdac complex facilitates temporal histone deacetylation at the cca1 and prr9 loci for robust circadian oscillation |
| topic | circadian clock chromatin modification histone deacetylase (HDAC) Sin3 histone deacetylase and corepressor complex CCA1 PRR9 |
| url | https://www.frontiersin.org/article/10.3389/fpls.2019.00171/full |
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