Medulloblastoma in an Adult With Late Extraneural Metastases to the Mediastinum
Background . Medulloblastoma, although the most common brain tumor of childhood, is exceedingly rare in adults. These tumors have a propensity for local recurrence and to metastasize along the leptomeninges; however, extraneural metastases are very rare and typically occur in the bone or bone marrow...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2014-04-01
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| Series: | Journal of Investigative Medicine High Impact Case Reports |
| Online Access: | https://doi.org/10.1177/2324709614532798 |
| _version_ | 1818492981881077760 |
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| author | Abhimanyu Ghose MD John C. Morris MD John C. Breneman MD James Essell MD Jiang Wang MD, PhD Sadia Benzaquen MD |
| author_facet | Abhimanyu Ghose MD John C. Morris MD John C. Breneman MD James Essell MD Jiang Wang MD, PhD Sadia Benzaquen MD |
| author_sort | Abhimanyu Ghose MD |
| collection | DOAJ |
| description | Background . Medulloblastoma, although the most common brain tumor of childhood, is exceedingly rare in adults. These tumors have a propensity for local recurrence and to metastasize along the leptomeninges; however, extraneural metastases are very rare and typically occur in the bone or bone marrow. We have not come across any case in literature of medulloblastoma with mediastinal metastases in an adult. Case Presentation . We report a case of medulloblastoma in a 38-year-old lady who was treated with surgery followed by craniospinal radiation. Ten years later she presented with hoarseness from true vocal cord paralysis. She was diagnosed to have infiltrating metastases of her medulloblastoma to the mediastinum, which was confirmed by biopsy. There was no local recurrence. This was treated with chemotherapy followed by stem cell rescue, and she remained progression free for 2 years. Conclusion . Medulloblastomas are rare in adults and can present with late extraneural metastases following treatment. Although most common reported sites are bone and bone marrow, late metastases to other unexpected areas like the mediastinum are possible too and warrant awareness. This can be treated with chemotherapy followed by high-dose chemotherapy and stem cell rescue in a young patient with good performance status. |
| first_indexed | 2024-12-10T17:49:22Z |
| format | Article |
| id | doaj.art-5dc646d429a640688722f483651716d5 |
| institution | Directory Open Access Journal |
| issn | 2324-7096 |
| language | English |
| last_indexed | 2024-12-10T17:49:22Z |
| publishDate | 2014-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Investigative Medicine High Impact Case Reports |
| spelling | doaj.art-5dc646d429a640688722f483651716d52022-12-22T01:39:06ZengSAGE PublishingJournal of Investigative Medicine High Impact Case Reports2324-70962014-04-01210.1177/232470961453279810.1177_2324709614532798Medulloblastoma in an Adult With Late Extraneural Metastases to the MediastinumAbhimanyu Ghose MD0John C. Morris MD1John C. Breneman MD2James Essell MD3Jiang Wang MD, PhD4Sadia Benzaquen MD5University of Cincinnati, Cincinnati, OH, USAUniversity of Cincinnati, Cincinnati, OH, USAUniversity of Cincinnati, Cincinnati, OH, USAOncology Hematology Care Inc, Cincinnati, OH, USAUniversity of Cincinnati, Cincinnati, OH, USAUniversity of Cincinnati, Cincinnati, OH, USABackground . Medulloblastoma, although the most common brain tumor of childhood, is exceedingly rare in adults. These tumors have a propensity for local recurrence and to metastasize along the leptomeninges; however, extraneural metastases are very rare and typically occur in the bone or bone marrow. We have not come across any case in literature of medulloblastoma with mediastinal metastases in an adult. Case Presentation . We report a case of medulloblastoma in a 38-year-old lady who was treated with surgery followed by craniospinal radiation. Ten years later she presented with hoarseness from true vocal cord paralysis. She was diagnosed to have infiltrating metastases of her medulloblastoma to the mediastinum, which was confirmed by biopsy. There was no local recurrence. This was treated with chemotherapy followed by stem cell rescue, and she remained progression free for 2 years. Conclusion . Medulloblastomas are rare in adults and can present with late extraneural metastases following treatment. Although most common reported sites are bone and bone marrow, late metastases to other unexpected areas like the mediastinum are possible too and warrant awareness. This can be treated with chemotherapy followed by high-dose chemotherapy and stem cell rescue in a young patient with good performance status.https://doi.org/10.1177/2324709614532798 |
| spellingShingle | Abhimanyu Ghose MD John C. Morris MD John C. Breneman MD James Essell MD Jiang Wang MD, PhD Sadia Benzaquen MD Medulloblastoma in an Adult With Late Extraneural Metastases to the Mediastinum Journal of Investigative Medicine High Impact Case Reports |
| title | Medulloblastoma in an Adult With Late Extraneural Metastases to the Mediastinum |
| title_full | Medulloblastoma in an Adult With Late Extraneural Metastases to the Mediastinum |
| title_fullStr | Medulloblastoma in an Adult With Late Extraneural Metastases to the Mediastinum |
| title_full_unstemmed | Medulloblastoma in an Adult With Late Extraneural Metastases to the Mediastinum |
| title_short | Medulloblastoma in an Adult With Late Extraneural Metastases to the Mediastinum |
| title_sort | medulloblastoma in an adult with late extraneural metastases to the mediastinum |
| url | https://doi.org/10.1177/2324709614532798 |
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