Autophagy-dependent ferroptosis in kidney disease
Ferroptosis is a new type of cell death caused by the lack of glutathione peroxidase 4 (GPX4) and the imbalance of cellular redox. It is characterized by the accumulation of lipid peroxides on cell membranes. Multiple regulatory pathways of ferroptosis include the GPX4, glutamate-cystine antiporter...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1071864/full |
| _version_ | 1797945466046906368 |
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| author | Yuanting Yang Jiayi Cheng Qisheng Lin Zhaohui Ni |
| author_facet | Yuanting Yang Jiayi Cheng Qisheng Lin Zhaohui Ni |
| author_sort | Yuanting Yang |
| collection | DOAJ |
| description | Ferroptosis is a new type of cell death caused by the lack of glutathione peroxidase 4 (GPX4) and the imbalance of cellular redox. It is characterized by the accumulation of lipid peroxides on cell membranes. Multiple regulatory pathways of ferroptosis include the GPX4, glutamate-cystine antiporter (System Xc–), lipid metabolism, and iron metabolism pathways. Recent studies have reported that autophagy-dependent ferroptosis (ferroptosis meditated by ferritinophagy, lipophagy, and clockophagy) plays a significant role in the occurrence of several diseases, including diseases affecting the nerves, liver, lungs, and kidneys. This review provides an overview of research progress made on autophagy-dependent ferroptosis in kidney diseases. |
| first_indexed | 2024-04-10T20:55:32Z |
| format | Article |
| id | doaj.art-5dc6bf4df133438da81b185069282719 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T20:55:32Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-5dc6bf4df133438da81b1850692827192023-01-23T04:52:35ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-01-01910.3389/fmed.2022.10718641071864Autophagy-dependent ferroptosis in kidney diseaseYuanting Yang0Jiayi Cheng1Qisheng Lin2Zhaohui Ni3Molecular Cell Lab for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, RenJi Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaTianping Community Health Service Center, Shanghai, ChinaMolecular Cell Lab for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, RenJi Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMolecular Cell Lab for Kidney Disease, Department of Nephrology, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, RenJi Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaFerroptosis is a new type of cell death caused by the lack of glutathione peroxidase 4 (GPX4) and the imbalance of cellular redox. It is characterized by the accumulation of lipid peroxides on cell membranes. Multiple regulatory pathways of ferroptosis include the GPX4, glutamate-cystine antiporter (System Xc–), lipid metabolism, and iron metabolism pathways. Recent studies have reported that autophagy-dependent ferroptosis (ferroptosis meditated by ferritinophagy, lipophagy, and clockophagy) plays a significant role in the occurrence of several diseases, including diseases affecting the nerves, liver, lungs, and kidneys. This review provides an overview of research progress made on autophagy-dependent ferroptosis in kidney diseases.https://www.frontiersin.org/articles/10.3389/fmed.2022.1071864/fullferroptosisautophagykidney diseasecell deathacute kidney injury |
| spellingShingle | Yuanting Yang Jiayi Cheng Qisheng Lin Zhaohui Ni Autophagy-dependent ferroptosis in kidney disease Frontiers in Medicine ferroptosis autophagy kidney disease cell death acute kidney injury |
| title | Autophagy-dependent ferroptosis in kidney disease |
| title_full | Autophagy-dependent ferroptosis in kidney disease |
| title_fullStr | Autophagy-dependent ferroptosis in kidney disease |
| title_full_unstemmed | Autophagy-dependent ferroptosis in kidney disease |
| title_short | Autophagy-dependent ferroptosis in kidney disease |
| title_sort | autophagy dependent ferroptosis in kidney disease |
| topic | ferroptosis autophagy kidney disease cell death acute kidney injury |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1071864/full |
| work_keys_str_mv | AT yuantingyang autophagydependentferroptosisinkidneydisease AT jiayicheng autophagydependentferroptosisinkidneydisease AT qishenglin autophagydependentferroptosisinkidneydisease AT zhaohuini autophagydependentferroptosisinkidneydisease |