Clinical blindness in conjunction with childhood bacterial meningitis
Abstract Although rarely reported, bilateral loss of vision is a severe complication of childhood bacterial meningitis. We assessed its frequency in five prospective treatment trials performed in Europe, Latin America, and Angola in 1984–2017. Course of illness, follow-up findings, and child’s sight...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-41685-2 |
| _version_ | 1827723302726008832 |
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| author | Tuula Pelkonen Markku Kallio Terho Latvala Irmeli Roine Heikki Peltola |
| author_facet | Tuula Pelkonen Markku Kallio Terho Latvala Irmeli Roine Heikki Peltola |
| author_sort | Tuula Pelkonen |
| collection | DOAJ |
| description | Abstract Although rarely reported, bilateral loss of vision is a severe complication of childhood bacterial meningitis. We assessed its frequency in five prospective treatment trials performed in Europe, Latin America, and Angola in 1984–2017. Course of illness, follow-up findings, and child’s sight were recorded. Sight was examined at discharge, and conditions permitting, also at 1–3 months post-hospitalization and in Angola on hospital day 7. Experienced pediatricians diagnosed clinical blindness if the child did not make eye contact, did not blink or move the eyes, or remained unresponsive to bright light or movement of large objects before their eyes. Of 1515 patients, 351, 654, and 510 were from Finland, Latin America, and Angola, respectively. At discharge, blindness was observed in 0 (0%), 8 (1.2%), and 51 (10%) children, respectively. In Angola, 64 children appeared to be blind on day 7; 16 of these children died. Blindness found at discharge in Angola was not invariably irreversible; approximately 40% had restored the sight at follow-up visit. Clinical blindness rarely occurred in isolation and was usually associated with young age and poor general condition at hospital arrival. Various other serious sequelae were common among the survivors with clinical blindness. |
| first_indexed | 2024-03-10T21:59:19Z |
| format | Article |
| id | doaj.art-5dc7a0af22ac4bf38eba93f601fb4d00 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T21:59:19Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-5dc7a0af22ac4bf38eba93f601fb4d002023-11-19T13:00:45ZengNature PortfolioScientific Reports2045-23222023-09-011311710.1038/s41598-023-41685-2Clinical blindness in conjunction with childhood bacterial meningitisTuula Pelkonen0Markku Kallio1Terho Latvala2Irmeli Roine3Heikki Peltola4Pediatrics, University of Helsinki and Helsinki University HospitalPediatrics, University of Helsinki and Helsinki University HospitalOphthalmology, Helsinki University Hospital, and University of HelsinkiFaculty of Medicine, University Diego PortalesPediatrics, University of Helsinki and Helsinki University HospitalAbstract Although rarely reported, bilateral loss of vision is a severe complication of childhood bacterial meningitis. We assessed its frequency in five prospective treatment trials performed in Europe, Latin America, and Angola in 1984–2017. Course of illness, follow-up findings, and child’s sight were recorded. Sight was examined at discharge, and conditions permitting, also at 1–3 months post-hospitalization and in Angola on hospital day 7. Experienced pediatricians diagnosed clinical blindness if the child did not make eye contact, did not blink or move the eyes, or remained unresponsive to bright light or movement of large objects before their eyes. Of 1515 patients, 351, 654, and 510 were from Finland, Latin America, and Angola, respectively. At discharge, blindness was observed in 0 (0%), 8 (1.2%), and 51 (10%) children, respectively. In Angola, 64 children appeared to be blind on day 7; 16 of these children died. Blindness found at discharge in Angola was not invariably irreversible; approximately 40% had restored the sight at follow-up visit. Clinical blindness rarely occurred in isolation and was usually associated with young age and poor general condition at hospital arrival. Various other serious sequelae were common among the survivors with clinical blindness.https://doi.org/10.1038/s41598-023-41685-2 |
| spellingShingle | Tuula Pelkonen Markku Kallio Terho Latvala Irmeli Roine Heikki Peltola Clinical blindness in conjunction with childhood bacterial meningitis Scientific Reports |
| title | Clinical blindness in conjunction with childhood bacterial meningitis |
| title_full | Clinical blindness in conjunction with childhood bacterial meningitis |
| title_fullStr | Clinical blindness in conjunction with childhood bacterial meningitis |
| title_full_unstemmed | Clinical blindness in conjunction with childhood bacterial meningitis |
| title_short | Clinical blindness in conjunction with childhood bacterial meningitis |
| title_sort | clinical blindness in conjunction with childhood bacterial meningitis |
| url | https://doi.org/10.1038/s41598-023-41685-2 |
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