CD81 and Hepatitis C Virus (HCV) Infection
Hepatitis C Virus (HCV) infection is a global public health problem affecting over 160 million individuals worldwide. Its symptoms include chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HCV is an enveloped RNA virus mainly targeting liver cells and for which the initiation of infec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-02-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/6/2/535 |
| _version_ | 1811327676185575424 |
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| author | Lucie Fénéant Shoshana Levy Laurence Cocquerel |
| author_facet | Lucie Fénéant Shoshana Levy Laurence Cocquerel |
| author_sort | Lucie Fénéant |
| collection | DOAJ |
| description | Hepatitis C Virus (HCV) infection is a global public health problem affecting over 160 million individuals worldwide. Its symptoms include chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HCV is an enveloped RNA virus mainly targeting liver cells and for which the initiation of infection occurs through a complex multistep process involving a series of specific cellular entry factors. This process is likely mediated through the formation of a tightly orchestrated complex of HCV entry factors at the plasma membrane. Among HCV entry factors, the tetraspanin CD81 is one of the best characterized and it is undoubtedly a key player in the HCV lifecycle. In this review, we detail the current knowledge on the involvement of CD81 in the HCV lifecycle, as well as in the immune response to HCV infection. |
| first_indexed | 2024-04-13T15:12:16Z |
| format | Article |
| id | doaj.art-5dca3cf7286044a1bfe174c41bcc118a |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-13T15:12:16Z |
| publishDate | 2014-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-5dca3cf7286044a1bfe174c41bcc118a2022-12-22T02:41:59ZengMDPI AGViruses1999-49152014-02-016253557210.3390/v6020535v6020535CD81 and Hepatitis C Virus (HCV) InfectionLucie Fénéant0Shoshana Levy1Laurence Cocquerel2Center for Infection and Immunity of Lille, CNRS-UMR8204, Inserm-U1019, Institut Pasteur de Lille, Université Lille Nord de France, Institut de Biologie de Lille, 1 rue du Pr Calmette, CS50447, 59021 Lille Cedex, FranceDepartment of Medicine, Division of Oncology, CCSR, Stanford University Medical Center, Stanford, CA 94305, USACenter for Infection and Immunity of Lille, CNRS-UMR8204, Inserm-U1019, Institut Pasteur de Lille, Université Lille Nord de France, Institut de Biologie de Lille, 1 rue du Pr Calmette, CS50447, 59021 Lille Cedex, FranceHepatitis C Virus (HCV) infection is a global public health problem affecting over 160 million individuals worldwide. Its symptoms include chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HCV is an enveloped RNA virus mainly targeting liver cells and for which the initiation of infection occurs through a complex multistep process involving a series of specific cellular entry factors. This process is likely mediated through the formation of a tightly orchestrated complex of HCV entry factors at the plasma membrane. Among HCV entry factors, the tetraspanin CD81 is one of the best characterized and it is undoubtedly a key player in the HCV lifecycle. In this review, we detail the current knowledge on the involvement of CD81 in the HCV lifecycle, as well as in the immune response to HCV infection.http://www.mdpi.com/1999-4915/6/2/535Hepatitis C VirusCD81tetraspaninsentry factorsviral lifecycleimmune response |
| spellingShingle | Lucie Fénéant Shoshana Levy Laurence Cocquerel CD81 and Hepatitis C Virus (HCV) Infection Viruses Hepatitis C Virus CD81 tetraspanins entry factors viral lifecycle immune response |
| title | CD81 and Hepatitis C Virus (HCV) Infection |
| title_full | CD81 and Hepatitis C Virus (HCV) Infection |
| title_fullStr | CD81 and Hepatitis C Virus (HCV) Infection |
| title_full_unstemmed | CD81 and Hepatitis C Virus (HCV) Infection |
| title_short | CD81 and Hepatitis C Virus (HCV) Infection |
| title_sort | cd81 and hepatitis c virus hcv infection |
| topic | Hepatitis C Virus CD81 tetraspanins entry factors viral lifecycle immune response |
| url | http://www.mdpi.com/1999-4915/6/2/535 |
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