The joint use of 99mTc-MAA-SPECT/CT and cone-beam CT optimizes radioembolization planning
Abstract Purpose To determine which imaging method used during radioembolization (RE) work-up: contrast-enhanced computed tomography (CECT), 99mTc-MAA-SPECT/CT or cone beam-CT (CBCT), more accurately predicts the final target volume (TgV) as well as the influence that each modality has in the dosime...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-03-01
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| Series: | EJNMMI Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13550-021-00764-z |
| _version_ | 1828896986216005632 |
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| author | Macarena Rodríguez-Fraile Ana Ezponda Fabiana Grisanti Verónica Morán Marta Calvo Pablo Berián Antonio Martínez de la Cuesta Lidia Sancho Mercedes Iñarrairaegui Bruno Sangro José Ignacio Bilbao |
| author_facet | Macarena Rodríguez-Fraile Ana Ezponda Fabiana Grisanti Verónica Morán Marta Calvo Pablo Berián Antonio Martínez de la Cuesta Lidia Sancho Mercedes Iñarrairaegui Bruno Sangro José Ignacio Bilbao |
| author_sort | Macarena Rodríguez-Fraile |
| collection | DOAJ |
| description | Abstract Purpose To determine which imaging method used during radioembolization (RE) work-up: contrast-enhanced computed tomography (CECT), 99mTc-MAA-SPECT/CT or cone beam-CT (CBCT), more accurately predicts the final target volume (TgV) as well as the influence that each modality has in the dosimetric calculation. Methods TgVs from 99mTc-MAA-SPECT/CT, CECT and CBCT were consecutively obtained in 24 patients treated with RE and compared with 90Y PET/CT TgV. Using the TgVs estimated by each imaging modality and a fictitious activity of 1 GBq, the corresponding absorbed doses by tumor and non-tumoral parenchyma were calculated for each patient. The absorbed doses for each modality were compared with the ones obtained using 90Y PET/CT TgV. Results 99mTc-MAA-SPECT/CT predicted 90Y PET/CT TgV better than CBCT or CECT, even for selective or superselective administrations. Likewise, 99mTc-MAA-SPECT/CT showed dosimetric values more similar to those obtained with 90Y PET/CT. Nevertheless, CBCT provided essential information for RE planning, such as ensuring the total coverage of the tumor and, in cases with more than one feeding artery, splitting the activity according to the volume of tumor perfused by each artery. Conclusion The joint use of 99mTc-MAA-SPECT/CT and CBCT optimizes dosimetric planning for RE procedures, enabling a more accurate personalized approach. |
| first_indexed | 2024-12-13T14:49:02Z |
| format | Article |
| id | doaj.art-5dcc2bbf1af644d4a199831d9f8fb4cb |
| institution | Directory Open Access Journal |
| issn | 2191-219X |
| language | English |
| last_indexed | 2024-12-13T14:49:02Z |
| publishDate | 2021-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Research |
| spelling | doaj.art-5dcc2bbf1af644d4a199831d9f8fb4cb2022-12-21T23:41:23ZengSpringerOpenEJNMMI Research2191-219X2021-03-0111111110.1186/s13550-021-00764-zThe joint use of 99mTc-MAA-SPECT/CT and cone-beam CT optimizes radioembolization planningMacarena Rodríguez-Fraile0Ana Ezponda1Fabiana Grisanti2Verónica Morán3Marta Calvo4Pablo Berián5Antonio Martínez de la Cuesta6Lidia Sancho7Mercedes Iñarrairaegui8Bruno Sangro9José Ignacio Bilbao10Nuclear Medicine Department, Clínica Universidad de NavarraRadiology Department, Clínica Universidad de NavarraNuclear Medicine Department, Clínica Universidad de NavarraMedical Physics Department, Clínica Universidad de NavarraRadiology Department, Clínica Universidad de NavarraRadiology Department, Clínica Universidad de NavarraRadiology Department, Clínica Universidad de NavarraNuclear Medicine Department, Clínica Universidad de NavarraDepartment of Internal Medicine-Hepatology, Clínica Universidad de NavarraDepartment of Internal Medicine-Hepatology, Clínica Universidad de NavarraRadiology Department, Clínica Universidad de NavarraAbstract Purpose To determine which imaging method used during radioembolization (RE) work-up: contrast-enhanced computed tomography (CECT), 99mTc-MAA-SPECT/CT or cone beam-CT (CBCT), more accurately predicts the final target volume (TgV) as well as the influence that each modality has in the dosimetric calculation. Methods TgVs from 99mTc-MAA-SPECT/CT, CECT and CBCT were consecutively obtained in 24 patients treated with RE and compared with 90Y PET/CT TgV. Using the TgVs estimated by each imaging modality and a fictitious activity of 1 GBq, the corresponding absorbed doses by tumor and non-tumoral parenchyma were calculated for each patient. The absorbed doses for each modality were compared with the ones obtained using 90Y PET/CT TgV. Results 99mTc-MAA-SPECT/CT predicted 90Y PET/CT TgV better than CBCT or CECT, even for selective or superselective administrations. Likewise, 99mTc-MAA-SPECT/CT showed dosimetric values more similar to those obtained with 90Y PET/CT. Nevertheless, CBCT provided essential information for RE planning, such as ensuring the total coverage of the tumor and, in cases with more than one feeding artery, splitting the activity according to the volume of tumor perfused by each artery. Conclusion The joint use of 99mTc-MAA-SPECT/CT and CBCT optimizes dosimetric planning for RE procedures, enabling a more accurate personalized approach.https://doi.org/10.1186/s13550-021-00764-zRadioembolization (RE)CBCTMAAPETDosimetryTarget volume |
| spellingShingle | Macarena Rodríguez-Fraile Ana Ezponda Fabiana Grisanti Verónica Morán Marta Calvo Pablo Berián Antonio Martínez de la Cuesta Lidia Sancho Mercedes Iñarrairaegui Bruno Sangro José Ignacio Bilbao The joint use of 99mTc-MAA-SPECT/CT and cone-beam CT optimizes radioembolization planning EJNMMI Research Radioembolization (RE) CBCT MAA PET Dosimetry Target volume |
| title | The joint use of 99mTc-MAA-SPECT/CT and cone-beam CT optimizes radioembolization planning |
| title_full | The joint use of 99mTc-MAA-SPECT/CT and cone-beam CT optimizes radioembolization planning |
| title_fullStr | The joint use of 99mTc-MAA-SPECT/CT and cone-beam CT optimizes radioembolization planning |
| title_full_unstemmed | The joint use of 99mTc-MAA-SPECT/CT and cone-beam CT optimizes radioembolization planning |
| title_short | The joint use of 99mTc-MAA-SPECT/CT and cone-beam CT optimizes radioembolization planning |
| title_sort | joint use of 99mtc maa spect ct and cone beam ct optimizes radioembolization planning |
| topic | Radioembolization (RE) CBCT MAA PET Dosimetry Target volume |
| url | https://doi.org/10.1186/s13550-021-00764-z |
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