Spatial regression analysis of MR diffusion reveals subject-specific white matter changes associated with repetitive head impacts in contact sports
Abstract Repetitive head impacts (RHI) are a growing concern due to their possible neurocognitive effects, with research showing a season of RHI produce white matter (WM) changes seen on neuroimaging. We conducted a secondary analysis of diffusion tensor imaging (DTI) data for 28 contact athletes to...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-70604-y |
| _version_ | 1818723101709434880 |
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| author | Patrick D. Asselin Yu Gu Kian Merchant-Borna Beau Abar David W. Wright Xing Qiu Jeff J. Bazarian |
| author_facet | Patrick D. Asselin Yu Gu Kian Merchant-Borna Beau Abar David W. Wright Xing Qiu Jeff J. Bazarian |
| author_sort | Patrick D. Asselin |
| collection | DOAJ |
| description | Abstract Repetitive head impacts (RHI) are a growing concern due to their possible neurocognitive effects, with research showing a season of RHI produce white matter (WM) changes seen on neuroimaging. We conducted a secondary analysis of diffusion tensor imaging (DTI) data for 28 contact athletes to compare WM changes. We collected pre-season and post-season DTI scans for each subject, approximately 3 months apart. We collected helmet data for the athletes, which we correlated with DTI data. We adapted the SPatial REgression Analysis of DTI (SPREAD) algorithm to conduct subject-specific longitudinal DTI analysis, and developed global inferential tools using functional norms and a novel robust p value combination test. At the individual level, most detected injured regions (93.3%) were associated with decreased FA values. Using meta-analysis techniques to combine injured regions across subjects, we found the combined injured region at the group level occupied the entire WM skeleton, suggesting the WM damage location is subject-specific. Several subject-specific functional summaries of SPREAD-detected WM change, e.g., the $${L}^{\infty }$$ L ∞ norm, significantly correlated with helmet impact measures, e.g. cumulative unweighted rotational acceleration (adjusted p = 0.0049), time between hits rotational acceleration (adjusted p value 0.0101), and time until DTI rotational acceleration (adjusted p = 0.0084), suggesting RHIs lead to WM changes. |
| first_indexed | 2024-12-17T21:05:10Z |
| format | Article |
| id | doaj.art-5dcc926abc264bdeaeb9df561d7de6a8 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T21:05:10Z |
| publishDate | 2020-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-5dcc926abc264bdeaeb9df561d7de6a82022-12-21T21:32:35ZengNature PortfolioScientific Reports2045-23222020-08-0110111210.1038/s41598-020-70604-ySpatial regression analysis of MR diffusion reveals subject-specific white matter changes associated with repetitive head impacts in contact sportsPatrick D. Asselin0Yu Gu1Kian Merchant-Borna2Beau Abar3David W. Wright4Xing Qiu5Jeff J. Bazarian6Department of Pediatrics, Boston Children’s HospitalDepartment of Biostatistics and Computational Biology, University of RochesterDepartment of Emergency Medicine, School of Medicine and Dentistry, University of RochesterDepartment of Emergency Medicine, School of Medicine and Dentistry, University of RochesterDepartment of Emergency Medicine, Emory UniversityDepartment of Biostatistics and Computational Biology, University of RochesterDepartment of Emergency Medicine, School of Medicine and Dentistry, University of RochesterAbstract Repetitive head impacts (RHI) are a growing concern due to their possible neurocognitive effects, with research showing a season of RHI produce white matter (WM) changes seen on neuroimaging. We conducted a secondary analysis of diffusion tensor imaging (DTI) data for 28 contact athletes to compare WM changes. We collected pre-season and post-season DTI scans for each subject, approximately 3 months apart. We collected helmet data for the athletes, which we correlated with DTI data. We adapted the SPatial REgression Analysis of DTI (SPREAD) algorithm to conduct subject-specific longitudinal DTI analysis, and developed global inferential tools using functional norms and a novel robust p value combination test. At the individual level, most detected injured regions (93.3%) were associated with decreased FA values. Using meta-analysis techniques to combine injured regions across subjects, we found the combined injured region at the group level occupied the entire WM skeleton, suggesting the WM damage location is subject-specific. Several subject-specific functional summaries of SPREAD-detected WM change, e.g., the $${L}^{\infty }$$ L ∞ norm, significantly correlated with helmet impact measures, e.g. cumulative unweighted rotational acceleration (adjusted p = 0.0049), time between hits rotational acceleration (adjusted p value 0.0101), and time until DTI rotational acceleration (adjusted p = 0.0084), suggesting RHIs lead to WM changes.https://doi.org/10.1038/s41598-020-70604-y |
| spellingShingle | Patrick D. Asselin Yu Gu Kian Merchant-Borna Beau Abar David W. Wright Xing Qiu Jeff J. Bazarian Spatial regression analysis of MR diffusion reveals subject-specific white matter changes associated with repetitive head impacts in contact sports Scientific Reports |
| title | Spatial regression analysis of MR diffusion reveals subject-specific white matter changes associated with repetitive head impacts in contact sports |
| title_full | Spatial regression analysis of MR diffusion reveals subject-specific white matter changes associated with repetitive head impacts in contact sports |
| title_fullStr | Spatial regression analysis of MR diffusion reveals subject-specific white matter changes associated with repetitive head impacts in contact sports |
| title_full_unstemmed | Spatial regression analysis of MR diffusion reveals subject-specific white matter changes associated with repetitive head impacts in contact sports |
| title_short | Spatial regression analysis of MR diffusion reveals subject-specific white matter changes associated with repetitive head impacts in contact sports |
| title_sort | spatial regression analysis of mr diffusion reveals subject specific white matter changes associated with repetitive head impacts in contact sports |
| url | https://doi.org/10.1038/s41598-020-70604-y |
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