Síndrome de imunização antifosfolipídica e trombose.
The designation of Antiphospholipid Syndrome was first applied by Harris in 1987, to a clinical status characterized by the detection of anticardiolipin and/or lupus anticoagulant with clinical thromboembolic manifestations. Recent advances in its study has shown that the inducing antigen is really...
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| Format: | Article |
| Language: | English |
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Ordem dos Médicos
1994-11-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2979 |
| _version_ | 1811242272118800384 |
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| author | J C de Sousa F Carriço |
| author_facet | J C de Sousa F Carriço |
| author_sort | J C de Sousa |
| collection | DOAJ |
| description | The designation of Antiphospholipid Syndrome was first applied by Harris in 1987, to a clinical status characterized by the detection of anticardiolipin and/or lupus anticoagulant with clinical thromboembolic manifestations. Recent advances in its study has shown that the inducing antigen is really a complex of phospholipid and protein. Therefore, it became clear that there is a need for a protein cofactor to the formation and action of antiphospholipid antibodies (APL). The authors present a detailed revision of the nature and specificity of APL, described as its proteic counterpart. Their action is surely conditioned by the specific protein involved with phospholipids, as it may be with Beta 2-Glycoprotein 1, Prothrombin, Protein c and s, Anexin V and the association of plasminogen and t-PA. The isotype of immunoglobulins is also very heterogeneous, since it was detected as IgG as well as IgA and IgM immunoglobulins. Furthermore, they can coexist in the same patient and with no clear relationship with thromboembolic manifestations. These aspects demonstrate well the greater variability that is found in these patients in relation to clinical and laboratory manifestations of the disease. For laboratory diagnosis, micro ELISA systems were developed, allowing the identification of antiphospholipid immunoglobulins with relative specificity and accuracy. Finally, the most frequent clinical expression is described, emphasising the pitfalls of clinical and laboratory diagnosis of the antiphospholipid syndrome. |
| first_indexed | 2024-04-12T13:49:19Z |
| format | Article |
| id | doaj.art-5dcd5b8eec504b9482bf43ad8ea1107e |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-12T13:49:19Z |
| publishDate | 1994-11-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-5dcd5b8eec504b9482bf43ad8ea1107e2022-12-22T03:30:35ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07581994-11-0171110.20344/amp.2979Síndrome de imunização antifosfolipídica e trombose.J C de Sousa0F CarriçoInstituto de Trombose e Hemostase, Hospital de Santa Maria, Lisboa.The designation of Antiphospholipid Syndrome was first applied by Harris in 1987, to a clinical status characterized by the detection of anticardiolipin and/or lupus anticoagulant with clinical thromboembolic manifestations. Recent advances in its study has shown that the inducing antigen is really a complex of phospholipid and protein. Therefore, it became clear that there is a need for a protein cofactor to the formation and action of antiphospholipid antibodies (APL). The authors present a detailed revision of the nature and specificity of APL, described as its proteic counterpart. Their action is surely conditioned by the specific protein involved with phospholipids, as it may be with Beta 2-Glycoprotein 1, Prothrombin, Protein c and s, Anexin V and the association of plasminogen and t-PA. The isotype of immunoglobulins is also very heterogeneous, since it was detected as IgG as well as IgA and IgM immunoglobulins. Furthermore, they can coexist in the same patient and with no clear relationship with thromboembolic manifestations. These aspects demonstrate well the greater variability that is found in these patients in relation to clinical and laboratory manifestations of the disease. For laboratory diagnosis, micro ELISA systems were developed, allowing the identification of antiphospholipid immunoglobulins with relative specificity and accuracy. Finally, the most frequent clinical expression is described, emphasising the pitfalls of clinical and laboratory diagnosis of the antiphospholipid syndrome.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2979 |
| spellingShingle | J C de Sousa F Carriço Síndrome de imunização antifosfolipídica e trombose. Acta Médica Portuguesa |
| title | Síndrome de imunização antifosfolipídica e trombose. |
| title_full | Síndrome de imunização antifosfolipídica e trombose. |
| title_fullStr | Síndrome de imunização antifosfolipídica e trombose. |
| title_full_unstemmed | Síndrome de imunização antifosfolipídica e trombose. |
| title_short | Síndrome de imunização antifosfolipídica e trombose. |
| title_sort | sindrome de imunizacao antifosfolipidica e trombose |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/2979 |
| work_keys_str_mv | AT jcdesousa sindromedeimunizacaoantifosfolipidicaetrombose AT fcarrico sindromedeimunizacaoantifosfolipidicaetrombose |