Evaluation of Feeding Beta-Hydroxy-Beta-Methylbutyrate (HMB) to Mouse Dams during Gestation on Birth Weight and Growth Variation of Offspring
This study was designed to determine if feeding β-hydroxy-β-methylbutyrate (HMB) to pregnant mice would improve birth weight uniformity and growth performance of offspring. Dams (Agouti A<sup>vy</sup>) were assigned to one of four treatments: control (CON; <i>n</i> = 13), low...
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MDPI AG
2023-10-01
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| author | Anna S. Clarke Chris Faulk Gerald C. Shurson Daniel D. Gallaher Lee J. Johnston |
| author_facet | Anna S. Clarke Chris Faulk Gerald C. Shurson Daniel D. Gallaher Lee J. Johnston |
| author_sort | Anna S. Clarke |
| collection | DOAJ |
| description | This study was designed to determine if feeding β-hydroxy-β-methylbutyrate (HMB) to pregnant mice would improve birth weight uniformity and growth performance of offspring. Dams (Agouti A<sup>vy</sup>) were assigned to one of four treatments: control (CON; <i>n</i> = 13), low-level HMB (LL; 3.5 mg/g; <i>n</i> = 14), high-level HMB (HL; 35 mg/g; <i>n</i> = 15), and low-level pulse dose fed from gestational days 6 to 10 (PUL; 3.5 mg/g; <i>n</i> = 14). Randomly selected dams (<i>n</i> = 27) were euthanized on gestational day 18 to collect placentae and pup weights. The remaining dams gave birth and lactated for 28 days. Dams only received HMB during gestation. Dietary HMB did not influence the performance of dams. Dietary treatment during gestation did not affect litter size or birth weight of pups. Variation was not different among treatments in terms of birth weight of offspring. Placental weights were not affected by treatments. Overall, growth performance of offspring after weaning was similar among all treatments. Body composition of offspring at 5 and 8 weeks of age was similar regardless of HMB treatment during gestation. In conclusion, dietary HMB supplementation in pregnant mice did not affect birth weight, variations in birth weight, or growth performance of offspring. |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T21:30:17Z |
| publishDate | 2023-10-01 |
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| series | Animals |
| spelling | doaj.art-5dcd7b306b0742edac0c46af2ae5e62e2023-11-19T15:24:55ZengMDPI AGAnimals2076-26152023-10-011320322710.3390/ani13203227Evaluation of Feeding Beta-Hydroxy-Beta-Methylbutyrate (HMB) to Mouse Dams during Gestation on Birth Weight and Growth Variation of OffspringAnna S. Clarke0Chris Faulk1Gerald C. Shurson2Daniel D. Gallaher3Lee J. Johnston4BioMatrix International, Princeton, MN 55371, USADepartment of Animal Science, University of Minnesota, St. Paul, MN 55108, USADepartment of Animal Science, University of Minnesota, St. Paul, MN 55108, USADepartment of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, USADepartment of Animal Science, University of Minnesota, St. Paul, MN 55108, USAThis study was designed to determine if feeding β-hydroxy-β-methylbutyrate (HMB) to pregnant mice would improve birth weight uniformity and growth performance of offspring. Dams (Agouti A<sup>vy</sup>) were assigned to one of four treatments: control (CON; <i>n</i> = 13), low-level HMB (LL; 3.5 mg/g; <i>n</i> = 14), high-level HMB (HL; 35 mg/g; <i>n</i> = 15), and low-level pulse dose fed from gestational days 6 to 10 (PUL; 3.5 mg/g; <i>n</i> = 14). Randomly selected dams (<i>n</i> = 27) were euthanized on gestational day 18 to collect placentae and pup weights. The remaining dams gave birth and lactated for 28 days. Dams only received HMB during gestation. Dietary HMB did not influence the performance of dams. Dietary treatment during gestation did not affect litter size or birth weight of pups. Variation was not different among treatments in terms of birth weight of offspring. Placental weights were not affected by treatments. Overall, growth performance of offspring after weaning was similar among all treatments. Body composition of offspring at 5 and 8 weeks of age was similar regardless of HMB treatment during gestation. In conclusion, dietary HMB supplementation in pregnant mice did not affect birth weight, variations in birth weight, or growth performance of offspring.https://www.mdpi.com/2076-2615/13/20/3227beta-hydroxy-beta-methylbutyratebirth weight variationgrowth performancemouseplacental efficiency |
| spellingShingle | Anna S. Clarke Chris Faulk Gerald C. Shurson Daniel D. Gallaher Lee J. Johnston Evaluation of Feeding Beta-Hydroxy-Beta-Methylbutyrate (HMB) to Mouse Dams during Gestation on Birth Weight and Growth Variation of Offspring Animals beta-hydroxy-beta-methylbutyrate birth weight variation growth performance mouse placental efficiency |
| title | Evaluation of Feeding Beta-Hydroxy-Beta-Methylbutyrate (HMB) to Mouse Dams during Gestation on Birth Weight and Growth Variation of Offspring |
| title_full | Evaluation of Feeding Beta-Hydroxy-Beta-Methylbutyrate (HMB) to Mouse Dams during Gestation on Birth Weight and Growth Variation of Offspring |
| title_fullStr | Evaluation of Feeding Beta-Hydroxy-Beta-Methylbutyrate (HMB) to Mouse Dams during Gestation on Birth Weight and Growth Variation of Offspring |
| title_full_unstemmed | Evaluation of Feeding Beta-Hydroxy-Beta-Methylbutyrate (HMB) to Mouse Dams during Gestation on Birth Weight and Growth Variation of Offspring |
| title_short | Evaluation of Feeding Beta-Hydroxy-Beta-Methylbutyrate (HMB) to Mouse Dams during Gestation on Birth Weight and Growth Variation of Offspring |
| title_sort | evaluation of feeding beta hydroxy beta methylbutyrate hmb to mouse dams during gestation on birth weight and growth variation of offspring |
| topic | beta-hydroxy-beta-methylbutyrate birth weight variation growth performance mouse placental efficiency |
| url | https://www.mdpi.com/2076-2615/13/20/3227 |
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