Novel Rotational Combination Regimen of Skin Topicals Improves Facial Photoaging: Efficacy Demonstrated in Double-Blinded Clinical Trials and Laboratory Validation
Topical antiaging products are often a first-line intervention to counter visible signs of facial photoaging, aiming for sustained cosmetic improvement. However, prolonged application of a single active topical compound was observed clinically to lead to a plateau effect in improving facial photoagi...
| প্রধান লেখক: | , , , , , , , , |
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| বিন্যাস: | প্রবন্ধ |
| ভাষা: | English |
| প্রকাশিত: |
Frontiers Media S.A.
2021-09-01
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| মালা: | Frontiers in Medicine |
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://www.frontiersin.org/articles/10.3389/fmed.2021.724344/full |
| _version_ | 1831669190181781504 |
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| author | Lisa DiNatale Jolanta Idkowiak-Baldys Young Zhuang Anthony Gonzalez Thomas J. Stephens Lily I. Jiang Weiping Li Rubinder Basson Ardeshir Bayat Ardeshir Bayat |
| author_facet | Lisa DiNatale Jolanta Idkowiak-Baldys Young Zhuang Anthony Gonzalez Thomas J. Stephens Lily I. Jiang Weiping Li Rubinder Basson Ardeshir Bayat Ardeshir Bayat |
| author_sort | Lisa DiNatale |
| collection | DOAJ |
| description | Topical antiaging products are often a first-line intervention to counter visible signs of facial photoaging, aiming for sustained cosmetic improvement. However, prolonged application of a single active topical compound was observed clinically to lead to a plateau effect in improving facial photoaging. In view of this, we set out to reduce this effect systematically using a multi-tiered approach with laboratory evidence and clinical trials. The objective of the study was to evaluate the effects of active topical ingredients applied either alone, in combination, or in a rotational manner on modulation of facial photoaging. The study methodology included in vitro, organotypic, and ex vivo skin explants; in vivo biopsy study; as well as clinical trials. We demonstrate for the first time that a pair of known antiaging ingredients applied rotationally, on human dermal fibroblasts, maximized pro-collagen I production. Indeed, rotational treatment with retinol and phytol/glycolic acid (PGA) resulted in better efficacy than application of each active ingredient alone as shown by explants and in vivo biopsy study, with penetration of active ingredients confirmed by Raman spectroscopy. Furthermore, two split-face, randomized, double-blinded clinical trials were conducted, one for 12 months to compare treated vs. untreated and the other for 6 months followed by a 2-month regression to compare treated vs. commercially marketed products. In both studies, rotational regimen showed superior results to its matching comparison as assessed by clinical grading and image analysis of crow's feet wrinkles. In conclusion, rotational regimen using retinol and PGA is effective in treating facial photoaging signs with long-lasting benefits. |
| first_indexed | 2024-12-19T22:54:50Z |
| format | Article |
| id | doaj.art-5dce4b3c9dd14143ac15b520a3eabf60 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-19T22:54:50Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-5dce4b3c9dd14143ac15b520a3eabf602022-12-21T20:02:41ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-09-01810.3389/fmed.2021.724344724344Novel Rotational Combination Regimen of Skin Topicals Improves Facial Photoaging: Efficacy Demonstrated in Double-Blinded Clinical Trials and Laboratory ValidationLisa DiNatale0Jolanta Idkowiak-Baldys1Young Zhuang2Anthony Gonzalez3Thomas J. Stephens4Lily I. Jiang5Weiping Li6Rubinder Basson7Ardeshir Bayat8Ardeshir Bayat9Global Innovation Center, Avon Products Inc., Avon Skin Care Institute, Suffern, NY, United StatesGlobal Innovation Center, Avon Products Inc., Avon Skin Care Institute, Suffern, NY, United StatesGlobal Innovation Center, Avon Products Inc., Avon Skin Care Institute, Suffern, NY, United StatesGlobal Innovation Center, Avon Products Inc., Avon Skin Care Institute, Suffern, NY, United StatesThomas J. Stephens & Associates, Inc., Richardson, TX, United StatesThomas J. Stephens & Associates, Inc., Richardson, TX, United StatesCentre for Dermatology Research, National Institute for Health Research Manchester Biomedical Research Centre, Stopford Building, University of Manchester, Manchester, United KingdomCentre for Dermatology Research, National Institute for Health Research Manchester Biomedical Research Centre, Stopford Building, University of Manchester, Manchester, United KingdomCentre for Dermatology Research, National Institute for Health Research Manchester Biomedical Research Centre, Stopford Building, University of Manchester, Manchester, United KingdomMedical Research Council of South Africa Wound Healing Unit, Hair and Skin Research Laboratory, Division of Dermatology, University of Cape Town, Cape Town, South AfricaTopical antiaging products are often a first-line intervention to counter visible signs of facial photoaging, aiming for sustained cosmetic improvement. However, prolonged application of a single active topical compound was observed clinically to lead to a plateau effect in improving facial photoaging. In view of this, we set out to reduce this effect systematically using a multi-tiered approach with laboratory evidence and clinical trials. The objective of the study was to evaluate the effects of active topical ingredients applied either alone, in combination, or in a rotational manner on modulation of facial photoaging. The study methodology included in vitro, organotypic, and ex vivo skin explants; in vivo biopsy study; as well as clinical trials. We demonstrate for the first time that a pair of known antiaging ingredients applied rotationally, on human dermal fibroblasts, maximized pro-collagen I production. Indeed, rotational treatment with retinol and phytol/glycolic acid (PGA) resulted in better efficacy than application of each active ingredient alone as shown by explants and in vivo biopsy study, with penetration of active ingredients confirmed by Raman spectroscopy. Furthermore, two split-face, randomized, double-blinded clinical trials were conducted, one for 12 months to compare treated vs. untreated and the other for 6 months followed by a 2-month regression to compare treated vs. commercially marketed products. In both studies, rotational regimen showed superior results to its matching comparison as assessed by clinical grading and image analysis of crow's feet wrinkles. In conclusion, rotational regimen using retinol and PGA is effective in treating facial photoaging signs with long-lasting benefits.https://www.frontiersin.org/articles/10.3389/fmed.2021.724344/fullrotational combination regimenskin cosmeticsskin topical applicationfacial photoagingcosmetic dermatology |
| spellingShingle | Lisa DiNatale Jolanta Idkowiak-Baldys Young Zhuang Anthony Gonzalez Thomas J. Stephens Lily I. Jiang Weiping Li Rubinder Basson Ardeshir Bayat Ardeshir Bayat Novel Rotational Combination Regimen of Skin Topicals Improves Facial Photoaging: Efficacy Demonstrated in Double-Blinded Clinical Trials and Laboratory Validation Frontiers in Medicine rotational combination regimen skin cosmetics skin topical application facial photoaging cosmetic dermatology |
| title | Novel Rotational Combination Regimen of Skin Topicals Improves Facial Photoaging: Efficacy Demonstrated in Double-Blinded Clinical Trials and Laboratory Validation |
| title_full | Novel Rotational Combination Regimen of Skin Topicals Improves Facial Photoaging: Efficacy Demonstrated in Double-Blinded Clinical Trials and Laboratory Validation |
| title_fullStr | Novel Rotational Combination Regimen of Skin Topicals Improves Facial Photoaging: Efficacy Demonstrated in Double-Blinded Clinical Trials and Laboratory Validation |
| title_full_unstemmed | Novel Rotational Combination Regimen of Skin Topicals Improves Facial Photoaging: Efficacy Demonstrated in Double-Blinded Clinical Trials and Laboratory Validation |
| title_short | Novel Rotational Combination Regimen of Skin Topicals Improves Facial Photoaging: Efficacy Demonstrated in Double-Blinded Clinical Trials and Laboratory Validation |
| title_sort | novel rotational combination regimen of skin topicals improves facial photoaging efficacy demonstrated in double blinded clinical trials and laboratory validation |
| topic | rotational combination regimen skin cosmetics skin topical application facial photoaging cosmetic dermatology |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.724344/full |
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