Differential regulation of skeletal stem/progenitor cells in distinct skeletal compartments
Skeletal stem/progenitor cells (SSPCs), characterized by self-renewal and multipotency, are essential for skeletal development, bone remodeling, and bone repair. These cells have traditionally been known to reside within the bone marrow, but recent studies have identified the presence of distinct SS...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1137063/full |
| _version_ | 1811162940029534208 |
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| author | Jea Giezl Niedo Solidum Jea Giezl Niedo Solidum Youngjae Jeong Francisco Heralde Dongsu Park Dongsu Park |
| author_facet | Jea Giezl Niedo Solidum Jea Giezl Niedo Solidum Youngjae Jeong Francisco Heralde Dongsu Park Dongsu Park |
| author_sort | Jea Giezl Niedo Solidum |
| collection | DOAJ |
| description | Skeletal stem/progenitor cells (SSPCs), characterized by self-renewal and multipotency, are essential for skeletal development, bone remodeling, and bone repair. These cells have traditionally been known to reside within the bone marrow, but recent studies have identified the presence of distinct SSPC populations in other skeletal compartments such as the growth plate, periosteum, and calvarial sutures. Differences in the cellular and matrix environment of distinct SSPC populations are believed to regulate their stemness and to direct their roles at different stages of development, homeostasis, and regeneration; differences in embryonic origin and adjacent tissue structures also affect SSPC regulation. As these SSPC niches are dynamic and highly specialized, changes under stress conditions and with aging can alter the cellular composition and molecular mechanisms in place, contributing to the dysregulation of local SSPCs and their activity in bone regeneration. Therefore, a better understanding of the different regulatory mechanisms for the distinct SSPCs in each skeletal compartment, and in different conditions, could provide answers to the existing knowledge gap and the impetus for realizing their potential in this biological and medical space. Here, we summarize the current scientific advances made in the study of the differential regulation pathways for distinct SSPCs in different bone compartments. We also discuss the physical, biological, and molecular factors that affect each skeletal compartment niche. Lastly, we look into how aging influences the regenerative capacity of SSPCs. Understanding these regulatory differences can open new avenues for the discovery of novel treatment approaches for calvarial or long bone repair. |
| first_indexed | 2024-04-10T06:37:18Z |
| format | Article |
| id | doaj.art-5dcef868a5a94aa6860f6cec1072e19d |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-10T06:37:18Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-5dcef868a5a94aa6860f6cec1072e19d2023-02-28T16:44:34ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-02-011410.3389/fphys.2023.11370631137063Differential regulation of skeletal stem/progenitor cells in distinct skeletal compartmentsJea Giezl Niedo Solidum0Jea Giezl Niedo Solidum1Youngjae Jeong2Francisco Heralde3Dongsu Park4Dongsu Park5Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, Manila, PhilippinesDepartment of Molecular and Human Genetics, Houston, TX, United StatesDepartment of Molecular and Human Genetics, Houston, TX, United StatesDepartment of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, Manila, PhilippinesDepartment of Molecular and Human Genetics, Houston, TX, United StatesCenter for Skeletal Biology, Baylor College of Medicine, Houston, TX, United StatesSkeletal stem/progenitor cells (SSPCs), characterized by self-renewal and multipotency, are essential for skeletal development, bone remodeling, and bone repair. These cells have traditionally been known to reside within the bone marrow, but recent studies have identified the presence of distinct SSPC populations in other skeletal compartments such as the growth plate, periosteum, and calvarial sutures. Differences in the cellular and matrix environment of distinct SSPC populations are believed to regulate their stemness and to direct their roles at different stages of development, homeostasis, and regeneration; differences in embryonic origin and adjacent tissue structures also affect SSPC regulation. As these SSPC niches are dynamic and highly specialized, changes under stress conditions and with aging can alter the cellular composition and molecular mechanisms in place, contributing to the dysregulation of local SSPCs and their activity in bone regeneration. Therefore, a better understanding of the different regulatory mechanisms for the distinct SSPCs in each skeletal compartment, and in different conditions, could provide answers to the existing knowledge gap and the impetus for realizing their potential in this biological and medical space. Here, we summarize the current scientific advances made in the study of the differential regulation pathways for distinct SSPCs in different bone compartments. We also discuss the physical, biological, and molecular factors that affect each skeletal compartment niche. Lastly, we look into how aging influences the regenerative capacity of SSPCs. Understanding these regulatory differences can open new avenues for the discovery of novel treatment approaches for calvarial or long bone repair.https://www.frontiersin.org/articles/10.3389/fphys.2023.1137063/fullperiosteumbone marrowgrowth platebone regenerationskeletal stem/progenitor cellssutures |
| spellingShingle | Jea Giezl Niedo Solidum Jea Giezl Niedo Solidum Youngjae Jeong Francisco Heralde Dongsu Park Dongsu Park Differential regulation of skeletal stem/progenitor cells in distinct skeletal compartments Frontiers in Physiology periosteum bone marrow growth plate bone regeneration skeletal stem/progenitor cells sutures |
| title | Differential regulation of skeletal stem/progenitor cells in distinct skeletal compartments |
| title_full | Differential regulation of skeletal stem/progenitor cells in distinct skeletal compartments |
| title_fullStr | Differential regulation of skeletal stem/progenitor cells in distinct skeletal compartments |
| title_full_unstemmed | Differential regulation of skeletal stem/progenitor cells in distinct skeletal compartments |
| title_short | Differential regulation of skeletal stem/progenitor cells in distinct skeletal compartments |
| title_sort | differential regulation of skeletal stem progenitor cells in distinct skeletal compartments |
| topic | periosteum bone marrow growth plate bone regeneration skeletal stem/progenitor cells sutures |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1137063/full |
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