miR-203 inhibits cell proliferation and migration of lung cancer cells by targeting PKCα.
PKCα (protein kinase C alpha, PRKCA) is an important protein involved in several steps of signaling pathways in lung cancer, and microRNAs (miRNAs) have also been shown to participate in lung carcinogenesis. However, it is not clear how PKCα and miRNAs are correlated in the disease. In this report,...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3769394?pdf=render |
| _version_ | 1819263815892598784 |
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| author | Chen Wang Xueliang Wang Hongwei Liang Tao Wang Xin Yan Minghui Cao Nan Wang Suyang Zhang Ke Zen Chenyu Zhang Xi Chen |
| author_facet | Chen Wang Xueliang Wang Hongwei Liang Tao Wang Xin Yan Minghui Cao Nan Wang Suyang Zhang Ke Zen Chenyu Zhang Xi Chen |
| author_sort | Chen Wang |
| collection | DOAJ |
| description | PKCα (protein kinase C alpha, PRKCA) is an important protein involved in several steps of signaling pathways in lung cancer, and microRNAs (miRNAs) have also been shown to participate in lung carcinogenesis. However, it is not clear how PKCα and miRNAs are correlated in the disease. In this report, we aimed to identify novel miRNAs that target PKCα and to study their biological function. Using bioinformatics analysis, we predicted one novel candidate, miR-203, and found differential expression patterns of miR-203 and PKCα in human lung cancer tissues. Moreover, we experimentally validated miR-203 as a direct regulator of PKCα. Finally, we demonstrated that the targeting of PKCα by miR-203 played a critical role in regulating cell proliferation, apoptosis and migration in lung cancer cells. In summary, this study identifies a novel miRNA that targets PKCα and illustrates that the downregulation of PKCα by miR-203 modulates biological processes in lung cancer cells. |
| first_indexed | 2024-12-23T20:19:35Z |
| format | Article |
| id | doaj.art-5dd216bebdf74a0f8b4dff8bd6b768b3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T20:19:35Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5dd216bebdf74a0f8b4dff8bd6b768b32022-12-21T17:32:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7398510.1371/journal.pone.0073985miR-203 inhibits cell proliferation and migration of lung cancer cells by targeting PKCα.Chen WangXueliang WangHongwei LiangTao WangXin YanMinghui CaoNan WangSuyang ZhangKe ZenChenyu ZhangXi ChenPKCα (protein kinase C alpha, PRKCA) is an important protein involved in several steps of signaling pathways in lung cancer, and microRNAs (miRNAs) have also been shown to participate in lung carcinogenesis. However, it is not clear how PKCα and miRNAs are correlated in the disease. In this report, we aimed to identify novel miRNAs that target PKCα and to study their biological function. Using bioinformatics analysis, we predicted one novel candidate, miR-203, and found differential expression patterns of miR-203 and PKCα in human lung cancer tissues. Moreover, we experimentally validated miR-203 as a direct regulator of PKCα. Finally, we demonstrated that the targeting of PKCα by miR-203 played a critical role in regulating cell proliferation, apoptosis and migration in lung cancer cells. In summary, this study identifies a novel miRNA that targets PKCα and illustrates that the downregulation of PKCα by miR-203 modulates biological processes in lung cancer cells.http://europepmc.org/articles/PMC3769394?pdf=render |
| spellingShingle | Chen Wang Xueliang Wang Hongwei Liang Tao Wang Xin Yan Minghui Cao Nan Wang Suyang Zhang Ke Zen Chenyu Zhang Xi Chen miR-203 inhibits cell proliferation and migration of lung cancer cells by targeting PKCα. PLoS ONE |
| title | miR-203 inhibits cell proliferation and migration of lung cancer cells by targeting PKCα. |
| title_full | miR-203 inhibits cell proliferation and migration of lung cancer cells by targeting PKCα. |
| title_fullStr | miR-203 inhibits cell proliferation and migration of lung cancer cells by targeting PKCα. |
| title_full_unstemmed | miR-203 inhibits cell proliferation and migration of lung cancer cells by targeting PKCα. |
| title_short | miR-203 inhibits cell proliferation and migration of lung cancer cells by targeting PKCα. |
| title_sort | mir 203 inhibits cell proliferation and migration of lung cancer cells by targeting pkcα |
| url | http://europepmc.org/articles/PMC3769394?pdf=render |
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