Dietary medium-chain fatty acids reduce food intake via the GDF15-GFRAL axis in mice

Dietary medium-chain fatty acids reduce food intake via the GDF15-GFRAL axis in mice

Objective: Medium chain fatty acids (MCFAs), which are fatty acids with chain lengths of 8–12 carbon atoms, have been shown to reduce food intake in rodents and humans, but the underlying mechanisms are unknown. Unlike most other fatty acids, MCFAs are absorbed from the intestine into the portal vei...

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Bibliographic Details
Main Authors: Josephine M. Kanta, Luisa Deisen, Kornelia Johann, Stephanie Holm, Annemarie Lundsgaard, Jens Lund, Markus Jähnert, Annette Schürmann, Christoffer Clemmensen, Bente Kiens, Andreas M. Fritzen, Maximilian Kleinert
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Molecular Metabolism
Subjects:
Medium-chain fatty acids
Growth/differentiation factor 15
Satiety
Lipid metabolism
Food intake
Hepatokine
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877823000947

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