Neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case report
A 40-year-old male presented with an orbital extension of conjunctival squamous cell carcinoma (SCC). The orbital mass was seen protruding outward from the left palpebral fissure overhanging the lower eyelid, completely obscuring the globe and lower lid. The patient gave a history of excision biopsy...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-01-01
|
| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2015;volume=63;issue=12;spage=927;epage=929;aulast=Nair |
| _version_ | 1818108035237675008 |
|---|---|
| author | Akshay Gopinathan Nair Swathi Kaliki Dilip Kumar Mishra Vijay Anand Reddy Milind N Naik |
| author_facet | Akshay Gopinathan Nair Swathi Kaliki Dilip Kumar Mishra Vijay Anand Reddy Milind N Naik |
| author_sort | Akshay Gopinathan Nair |
| collection | DOAJ |
| description | A 40-year-old male presented with an orbital extension of conjunctival squamous cell carcinoma (SCC). The orbital mass was seen protruding outward from the left palpebral fissure overhanging the lower eyelid, completely obscuring the globe and lower lid. The patient gave a history of excision biopsy, which was histopathologically diagnosed as ocular surface squamous neoplasia. He also gave a history of tumor recurrence, which gradually progressed to assume the form of the presently visible orbital mass. Computed tomography of the orbits showed the mass extending into the left orbit causing superior displacement of the globe. After a negative locoregional and systemic metastatic screening, neoadjuvant intravenous systemic chemotherapy with cisplatin and 5-fluorouracil were initiated in an attempt to reduce the size of the tumor. Three cycles of tri-weekly chemotherapy resulted in a significant reduction of the orbital tumor size with the globe and the lower lid being visible, thus making a lid-sparing orbital exenteration possible. The patient subsequently underwent an orbital exenteration and at 6-month follow-up, the patient was free from local and regional disease. To our knowledge, this is the first reported case where systemic neoadjuvant chemotherapy has been used to reduce the size of invasive SCC with orbital extension, thereby permitting a lid-sparing orbital exenteration. |
| first_indexed | 2024-12-11T02:08:57Z |
| format | Article |
| id | doaj.art-5dd5bf25466c488db8a078a4059907ba |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-11T02:08:57Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-5dd5bf25466c488db8a078a4059907ba2022-12-22T01:24:19ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892015-01-01631292792910.4103/0301-4738.176026Neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case reportAkshay Gopinathan NairSwathi KalikiDilip Kumar MishraVijay Anand ReddyMilind N NaikA 40-year-old male presented with an orbital extension of conjunctival squamous cell carcinoma (SCC). The orbital mass was seen protruding outward from the left palpebral fissure overhanging the lower eyelid, completely obscuring the globe and lower lid. The patient gave a history of excision biopsy, which was histopathologically diagnosed as ocular surface squamous neoplasia. He also gave a history of tumor recurrence, which gradually progressed to assume the form of the presently visible orbital mass. Computed tomography of the orbits showed the mass extending into the left orbit causing superior displacement of the globe. After a negative locoregional and systemic metastatic screening, neoadjuvant intravenous systemic chemotherapy with cisplatin and 5-fluorouracil were initiated in an attempt to reduce the size of the tumor. Three cycles of tri-weekly chemotherapy resulted in a significant reduction of the orbital tumor size with the globe and the lower lid being visible, thus making a lid-sparing orbital exenteration possible. The patient subsequently underwent an orbital exenteration and at 6-month follow-up, the patient was free from local and regional disease. To our knowledge, this is the first reported case where systemic neoadjuvant chemotherapy has been used to reduce the size of invasive SCC with orbital extension, thereby permitting a lid-sparing orbital exenteration.http://www.ijo.in/article.asp?issn=0301-4738;year=2015;volume=63;issue=12;spage=927;epage=929;aulast=NairChemotherapyconjunctivaexenterationeyeneoadjuvantocular surface squamous neoplasiasquamous cell carcinomatumor |
| spellingShingle | Akshay Gopinathan Nair Swathi Kaliki Dilip Kumar Mishra Vijay Anand Reddy Milind N Naik Neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case report Indian Journal of Ophthalmology Chemotherapy conjunctiva exenteration eye neoadjuvant ocular surface squamous neoplasia squamous cell carcinoma tumor |
| title | Neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case report |
| title_full | Neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case report |
| title_fullStr | Neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case report |
| title_full_unstemmed | Neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case report |
| title_short | Neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case report |
| title_sort | neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva a case report |
| topic | Chemotherapy conjunctiva exenteration eye neoadjuvant ocular surface squamous neoplasia squamous cell carcinoma tumor |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2015;volume=63;issue=12;spage=927;epage=929;aulast=Nair |
| work_keys_str_mv | AT akshaygopinathannair neoadjuvantchemotherapyforinvasivesquamouscellcarcinomaoftheconjunctivaacasereport AT swathikaliki neoadjuvantchemotherapyforinvasivesquamouscellcarcinomaoftheconjunctivaacasereport AT dilipkumarmishra neoadjuvantchemotherapyforinvasivesquamouscellcarcinomaoftheconjunctivaacasereport AT vijayanandreddy neoadjuvantchemotherapyforinvasivesquamouscellcarcinomaoftheconjunctivaacasereport AT milindnnaik neoadjuvantchemotherapyforinvasivesquamouscellcarcinomaoftheconjunctivaacasereport |