Urine Hydrogen Peroxide Levels and Their Relation to Outcome in Patients with Sepsis, Septic Shock, and Major Burn Injury
Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and oxidative stress have been suggested as possible instigators of both the systemic inflammatory response and the increased vascular permeability associated with sepsis and septic shock. We measured H<sub>2</sub>O&l...
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MDPI AG
2022-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/4/848 |
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| author | Miklos Lipcsey Maria Bergquist Rebecca Sirén Anders Larsson Fredrik Huss Jay Pravda Mia Furebring Jan Sjölin Helena Janols |
| author_facet | Miklos Lipcsey Maria Bergquist Rebecca Sirén Anders Larsson Fredrik Huss Jay Pravda Mia Furebring Jan Sjölin Helena Janols |
| author_sort | Miklos Lipcsey |
| collection | DOAJ |
| description | Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and oxidative stress have been suggested as possible instigators of both the systemic inflammatory response and the increased vascular permeability associated with sepsis and septic shock. We measured H<sub>2</sub>O<sub>2</sub> concentrations in the urine of 82 patients with severe infections, such as sepsis, septic shock, and infections not fulfilling sepsis-3 criteria, in patients with major burn injury with associated systemic inflammation, and healthy subjects. The mean concentrations of H<sub>2</sub>O<sub>2</sub> were found to be lower in patients with severe infections compared to burn injury patients and healthy subjects. Patients with acute kidney injury (AKI), vs. those without AKI, in all diagnostic groups displayed higher concentrations of urine H<sub>2</sub>O<sub>2</sub> (<i>p</i> < 0.001). Likewise, urine concentrations of H<sub>2</sub>O<sub>2</sub> were higher in non-survivors as compared to survivors (<i>p</i> < 0.001) at day 28 in all diagnostic groups, as well as in patients with severe infections and burn injury (<i>p</i> < 0.001 for both). In this cohort, increased H<sub>2</sub>O<sub>2</sub> in urine is thus associated with mortality in patients with sepsis and septic shock as well as in patients with burn injury. |
| first_indexed | 2024-03-09T11:07:03Z |
| format | Article |
| id | doaj.art-5dd648c5c0364b58806b646095ed6cba |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T11:07:03Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-5dd648c5c0364b58806b646095ed6cba2023-12-01T00:54:16ZengMDPI AGBiomedicines2227-90592022-04-0110484810.3390/biomedicines10040848Urine Hydrogen Peroxide Levels and Their Relation to Outcome in Patients with Sepsis, Septic Shock, and Major Burn InjuryMiklos Lipcsey0Maria Bergquist1Rebecca Sirén2Anders Larsson3Fredrik Huss4Jay Pravda5Mia Furebring6Jan Sjölin7Helena Janols8Hedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, SwedenDepartment of Medical Sciences, Clinical Physiology, Uppsala University, 75185 Uppsala, SwedenDepartment of Medicine, Danderyd Hospital, 18288 Stockholm, SwedenDepartment of Medical Sciences, Clinical Chemistry, Uppsala University, 75185 Uppsala, SwedenBurn Center, Department of Plastic and Maxillofacial Surgery, Uppsala University Hospital, 75185 Uppsala, SwedenInflammatory Disease Research Centre, Therashock LLC, Palm Beach Gardens, FL 33410, USADepartment of Medical Sciences, Section of Infectious Diseases, Uppsala University, 75185 Uppsala, SwedenDepartment of Medical Sciences, Section of Infectious Diseases, Uppsala University, 75185 Uppsala, SwedenDepartment of Medical Sciences, Section of Infectious Diseases, Uppsala University, 75185 Uppsala, SwedenHydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and oxidative stress have been suggested as possible instigators of both the systemic inflammatory response and the increased vascular permeability associated with sepsis and septic shock. We measured H<sub>2</sub>O<sub>2</sub> concentrations in the urine of 82 patients with severe infections, such as sepsis, septic shock, and infections not fulfilling sepsis-3 criteria, in patients with major burn injury with associated systemic inflammation, and healthy subjects. The mean concentrations of H<sub>2</sub>O<sub>2</sub> were found to be lower in patients with severe infections compared to burn injury patients and healthy subjects. Patients with acute kidney injury (AKI), vs. those without AKI, in all diagnostic groups displayed higher concentrations of urine H<sub>2</sub>O<sub>2</sub> (<i>p</i> < 0.001). Likewise, urine concentrations of H<sub>2</sub>O<sub>2</sub> were higher in non-survivors as compared to survivors (<i>p</i> < 0.001) at day 28 in all diagnostic groups, as well as in patients with severe infections and burn injury (<i>p</i> < 0.001 for both). In this cohort, increased H<sub>2</sub>O<sub>2</sub> in urine is thus associated with mortality in patients with sepsis and septic shock as well as in patients with burn injury.https://www.mdpi.com/2227-9059/10/4/848hydrogen peroxideH<sub>2</sub>O<sub>2</sub>sepsisshockburn injuryTBSA |
| spellingShingle | Miklos Lipcsey Maria Bergquist Rebecca Sirén Anders Larsson Fredrik Huss Jay Pravda Mia Furebring Jan Sjölin Helena Janols Urine Hydrogen Peroxide Levels and Their Relation to Outcome in Patients with Sepsis, Septic Shock, and Major Burn Injury Biomedicines hydrogen peroxide H<sub>2</sub>O<sub>2</sub> sepsis shock burn injury TBSA |
| title | Urine Hydrogen Peroxide Levels and Their Relation to Outcome in Patients with Sepsis, Septic Shock, and Major Burn Injury |
| title_full | Urine Hydrogen Peroxide Levels and Their Relation to Outcome in Patients with Sepsis, Septic Shock, and Major Burn Injury |
| title_fullStr | Urine Hydrogen Peroxide Levels and Their Relation to Outcome in Patients with Sepsis, Septic Shock, and Major Burn Injury |
| title_full_unstemmed | Urine Hydrogen Peroxide Levels and Their Relation to Outcome in Patients with Sepsis, Septic Shock, and Major Burn Injury |
| title_short | Urine Hydrogen Peroxide Levels and Their Relation to Outcome in Patients with Sepsis, Septic Shock, and Major Burn Injury |
| title_sort | urine hydrogen peroxide levels and their relation to outcome in patients with sepsis septic shock and major burn injury |
| topic | hydrogen peroxide H<sub>2</sub>O<sub>2</sub> sepsis shock burn injury TBSA |
| url | https://www.mdpi.com/2227-9059/10/4/848 |
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