Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse
T cell receptor (TCR) engagement opens Ca2+ release-activated Ca2+ (CRAC) channels and triggers formation of an immune synapse between T cells and antigen-presenting cells. At the synapse, actin reorganizes into a concentric lamellipod and lamella with retrograde actin flow that helps regulate the i...
Main Authors: | Catherine A Hartzell, Katarzyna I Jankowska, Janis K Burkhardt, Richard S Lewis |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-07-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/14850 |
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