The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation
LSH/HELLS is a chromatin remodeler promoting incorporation of histone variant macroH2A. Here the authors reveal a role for LSH in genome stability, in protecting nascent DNA at stalled forks mediated by macroH2A deposition and RAD51 filament formation.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23809-2 |
| _version_ | 1818435122265849856 |
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| author | Xiaoping Xu Kai Ni Yafeng He Jianke Ren Chongkui Sun Yie Liu Mirit I. Aladjem Sandra Burkett Richard Finney Xia Ding Shyam K. Sharan Kathrin Muegge |
| author_facet | Xiaoping Xu Kai Ni Yafeng He Jianke Ren Chongkui Sun Yie Liu Mirit I. Aladjem Sandra Burkett Richard Finney Xia Ding Shyam K. Sharan Kathrin Muegge |
| author_sort | Xiaoping Xu |
| collection | DOAJ |
| description | LSH/HELLS is a chromatin remodeler promoting incorporation of histone variant macroH2A. Here the authors reveal a role for LSH in genome stability, in protecting nascent DNA at stalled forks mediated by macroH2A deposition and RAD51 filament formation. |
| first_indexed | 2024-12-14T16:47:52Z |
| format | Article |
| id | doaj.art-5dd84ce1725948758084a5a36813c4ed |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:47:52Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5dd84ce1725948758084a5a36813c4ed2022-12-21T22:54:08ZengNature PortfolioNature Communications2041-17232021-06-0112111610.1038/s41467-021-23809-2The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formationXiaoping Xu0Kai Ni1Yafeng He2Jianke Ren3Chongkui Sun4Yie Liu5Mirit I. Aladjem6Sandra Burkett7Richard Finney8Xia Ding9Shyam K. Sharan10Kathrin Muegge11Epigenetics Section, Mouse Cancer Genetics Program, National Cancer InstituteEpigenetics Section, Mouse Cancer Genetics Program, National Cancer InstituteEpigenetics Section, Mouse Cancer Genetics Program, National Cancer InstituteEpigenetics Section, Mouse Cancer Genetics Program, National Cancer InstituteLaboratory of Molecular Gerontology, National Institute on Aging, NIHLaboratory of Molecular Gerontology, National Institute on Aging, NIHDevelopmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of HealthMolecular Cytogenetics Core Facility, MCGP, CCR, National Cancer Institute, NIHCCR Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer InstituteGenetics of Cancer Susceptibility Section, Mouse Cancer Genetics Program, National Cancer InstituteGenetics of Cancer Susceptibility Section, Mouse Cancer Genetics Program, National Cancer InstituteEpigenetics Section, Mouse Cancer Genetics Program, National Cancer InstituteLSH/HELLS is a chromatin remodeler promoting incorporation of histone variant macroH2A. Here the authors reveal a role for LSH in genome stability, in protecting nascent DNA at stalled forks mediated by macroH2A deposition and RAD51 filament formation.https://doi.org/10.1038/s41467-021-23809-2 |
| spellingShingle | Xiaoping Xu Kai Ni Yafeng He Jianke Ren Chongkui Sun Yie Liu Mirit I. Aladjem Sandra Burkett Richard Finney Xia Ding Shyam K. Sharan Kathrin Muegge The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation Nature Communications |
| title | The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation |
| title_full | The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation |
| title_fullStr | The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation |
| title_full_unstemmed | The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation |
| title_short | The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation |
| title_sort | epigenetic regulator lsh maintains fork protection and genomic stability via macroh2a deposition and rad51 filament formation |
| url | https://doi.org/10.1038/s41467-021-23809-2 |
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