MULTICOMPONENT SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ANALYSIS OF DELAPRIL AND INDAPAMIDE IN TABLETS
A multicomponent ultraviolet (UV) spectrophotometric method was developed and validated for simultaneous determination of delapril (DEL) and indapamide (IND) in tablets employing the partial least squares regression (PLSR) approach. The PLSR method was developed by a multilevel factorial design usi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Universidade Federal do Rio Grande do Sul
2017-08-01
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| Series: | Drug Analytical Research |
| Online Access: | https://seer.ufrgs.br/index.php/poled/management/settings/website/index.php/dar/article/view/74119 |
| _version_ | 1797318049853865984 |
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| author | Vitor Todeschini Regiane Leite Maximiliano Sangoi Paulo Oliveira Thiago Barth |
| author_facet | Vitor Todeschini Regiane Leite Maximiliano Sangoi Paulo Oliveira Thiago Barth |
| author_sort | Vitor Todeschini |
| collection | DOAJ |
| description |
A multicomponent ultraviolet (UV) spectrophotometric method was developed and validated for simultaneous determination of delapril (DEL) and indapamide (IND) in tablets employing the partial least squares regression (PLSR) approach. The PLSR method was developed by a multilevel factorial design using 25 synthetic mixtures of drugs and a significant predict model (p < 0.05) were obtained at 225 nm for DEL (r2 = 0.9992) and 243 nm for IND (r2 = 0.9997). Validation parameters such as the specificity, linearity, precision, accuracy and robustness were evaluated in accordance with the ICH requirements, giving satisfactory results within the acceptable range. The proposed PLSR method was successfully applied for simultaneous determination of DEL and IND in fixed dose combinations and can be used as simple alternative to separation techniques.
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| first_indexed | 2024-03-08T03:44:50Z |
| format | Article |
| id | doaj.art-5dd8a7303d324adca9e83f8d81e70cd8 |
| institution | Directory Open Access Journal |
| issn | 2527-2616 |
| language | English |
| last_indexed | 2024-03-08T03:44:50Z |
| publishDate | 2017-08-01 |
| publisher | Universidade Federal do Rio Grande do Sul |
| record_format | Article |
| series | Drug Analytical Research |
| spelling | doaj.art-5dd8a7303d324adca9e83f8d81e70cd82024-02-09T18:15:03ZengUniversidade Federal do Rio Grande do SulDrug Analytical Research2527-26162017-08-0111MULTICOMPONENT SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ANALYSIS OF DELAPRIL AND INDAPAMIDE IN TABLETSVitor Todeschini0Regiane Leite1Maximiliano Sangoi2Paulo Oliveira3Thiago Barth4Federal University of Rio de JaneiroFederal University of Rio de JaneiroFederal University of Rio de JaneiroState University of Centro OesteFederal University of Rio de Janeiro A multicomponent ultraviolet (UV) spectrophotometric method was developed and validated for simultaneous determination of delapril (DEL) and indapamide (IND) in tablets employing the partial least squares regression (PLSR) approach. The PLSR method was developed by a multilevel factorial design using 25 synthetic mixtures of drugs and a significant predict model (p < 0.05) were obtained at 225 nm for DEL (r2 = 0.9992) and 243 nm for IND (r2 = 0.9997). Validation parameters such as the specificity, linearity, precision, accuracy and robustness were evaluated in accordance with the ICH requirements, giving satisfactory results within the acceptable range. The proposed PLSR method was successfully applied for simultaneous determination of DEL and IND in fixed dose combinations and can be used as simple alternative to separation techniques. https://seer.ufrgs.br/index.php/poled/management/settings/website/index.php/dar/article/view/74119 |
| spellingShingle | Vitor Todeschini Regiane Leite Maximiliano Sangoi Paulo Oliveira Thiago Barth MULTICOMPONENT SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ANALYSIS OF DELAPRIL AND INDAPAMIDE IN TABLETS Drug Analytical Research |
| title | MULTICOMPONENT SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ANALYSIS OF DELAPRIL AND INDAPAMIDE IN TABLETS |
| title_full | MULTICOMPONENT SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ANALYSIS OF DELAPRIL AND INDAPAMIDE IN TABLETS |
| title_fullStr | MULTICOMPONENT SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ANALYSIS OF DELAPRIL AND INDAPAMIDE IN TABLETS |
| title_full_unstemmed | MULTICOMPONENT SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ANALYSIS OF DELAPRIL AND INDAPAMIDE IN TABLETS |
| title_short | MULTICOMPONENT SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ANALYSIS OF DELAPRIL AND INDAPAMIDE IN TABLETS |
| title_sort | multicomponent spectrophotometric method for simultaneous analysis of delapril and indapamide in tablets |
| url | https://seer.ufrgs.br/index.php/poled/management/settings/website/index.php/dar/article/view/74119 |
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