Effect of Adding Fentanyl to Bupivacaine on Patients Undergoing Transurethral Resection of the Prostate with Spinal Anesthesia: A Clinical trial
Background and purpose: Spinal anesthesia is commonly used in transurethral resection of the prostate (TURP). To reduce the complications of spinal anesthesia, opioids could be helpful in decreasing the amount of anesthetic drug. The aim of this study was to evaluate the effect of low doses of bupiv...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2020-05-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-14019-en.html |
| _version_ | 1828055069650583552 |
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| author | Maedeh Jafarzadeh Hakimeh Alereza Ebrahim Alijanpour Mehrafza Mir Soraya Khafri Emadoddin Moudi |
| author_facet | Maedeh Jafarzadeh Hakimeh Alereza Ebrahim Alijanpour Mehrafza Mir Soraya Khafri Emadoddin Moudi |
| author_sort | Maedeh Jafarzadeh |
| collection | DOAJ |
| description | Background and purpose: Spinal anesthesia is commonly used in transurethral resection of the prostate (TURP). To reduce the complications of spinal anesthesia, opioids could be helpful in decreasing the amount of anesthetic drug. The aim of this study was to evaluate the effect of low doses of bupivacaine and fentanyl on the levels of sensory block and motor block.
Materials and methods: A clinical trial was conducted in 80 TURP candidates in Babol Rouhani Hospital, 2016-2017. They were randomly divided into two groups (n= 40 per group) to receive either 7.5 mg bupivacaine 0.5% and 25 mcg of fentanyl (BF group) or 10mg bupivacaine 0.5% (B group). Duration of anesthesia, motor block (using Bromage score), pain intensity during the operation, and mean arterial pressure were recorded. Data were analyzed in SPSS V20.
Results: There were no significant differences between the two groups in duration of anesthesia and mean arterial pressure (P<0.05). The mean score for pain was significantly lower in BF group than the B group (P=0.007). The levels of sensory block in group B were significantly higher than the BF group (P<0.001). Also, motor block return time and recovery time were significantly shorter in BF group than those in B group (P<0.001).
Conclusion: According to the current study, administration of bupivacaine and fentanyl can cause appropriate level of sensory block and could relief pain during TURP. Also, some complications such as long-term motor block and long-term staying in recovery would reduce.
(Clinical Trials Registry Number: IRCT201702226148N4) |
| first_indexed | 2024-04-10T20:32:48Z |
| format | Article |
| id | doaj.art-5ddac419b5504c7496344d264717b4f8 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-04-10T20:32:48Z |
| publishDate | 2020-05-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-5ddac419b5504c7496344d264717b4f82023-01-25T05:03:41ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792020-05-01301844049Effect of Adding Fentanyl to Bupivacaine on Patients Undergoing Transurethral Resection of the Prostate with Spinal Anesthesia: A Clinical trialMaedeh Jafarzadeh0Hakimeh Alereza1Ebrahim Alijanpour2Mehrafza Mir3Soraya Khafri4Emadoddin Moudi5 Medical Student, Student Research Committee, Babol University of Medical Sciences, Babol, Iran Assistant Professor, Department of Anesthesiology, Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Assistant Professor, Department of Anesthesiology, Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Assistant Professor, Department of Anesthesiology, Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Associate Proffessor, Department of Statistics and Epidmiology, Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Associate Proffessor, Department of Urology, Clinical Research Development Center of Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran Background and purpose: Spinal anesthesia is commonly used in transurethral resection of the prostate (TURP). To reduce the complications of spinal anesthesia, opioids could be helpful in decreasing the amount of anesthetic drug. The aim of this study was to evaluate the effect of low doses of bupivacaine and fentanyl on the levels of sensory block and motor block. Materials and methods: A clinical trial was conducted in 80 TURP candidates in Babol Rouhani Hospital, 2016-2017. They were randomly divided into two groups (n= 40 per group) to receive either 7.5 mg bupivacaine 0.5% and 25 mcg of fentanyl (BF group) or 10mg bupivacaine 0.5% (B group). Duration of anesthesia, motor block (using Bromage score), pain intensity during the operation, and mean arterial pressure were recorded. Data were analyzed in SPSS V20. Results: There were no significant differences between the two groups in duration of anesthesia and mean arterial pressure (P<0.05). The mean score for pain was significantly lower in BF group than the B group (P=0.007). The levels of sensory block in group B were significantly higher than the BF group (P<0.001). Also, motor block return time and recovery time were significantly shorter in BF group than those in B group (P<0.001). Conclusion: According to the current study, administration of bupivacaine and fentanyl can cause appropriate level of sensory block and could relief pain during TURP. Also, some complications such as long-term motor block and long-term staying in recovery would reduce. (Clinical Trials Registry Number: IRCT201702226148N4)http://jmums.mazums.ac.ir/article-1-14019-en.htmlbupivacainefentanylspinal anesthesiamean arterial pressurehemodynamicstransurethral resection of the prostate |
| spellingShingle | Maedeh Jafarzadeh Hakimeh Alereza Ebrahim Alijanpour Mehrafza Mir Soraya Khafri Emadoddin Moudi Effect of Adding Fentanyl to Bupivacaine on Patients Undergoing Transurethral Resection of the Prostate with Spinal Anesthesia: A Clinical trial Journal of Mazandaran University of Medical Sciences bupivacaine fentanyl spinal anesthesia mean arterial pressure hemodynamics transurethral resection of the prostate |
| title | Effect of Adding Fentanyl to Bupivacaine on Patients Undergoing Transurethral Resection of the Prostate with Spinal Anesthesia: A Clinical trial |
| title_full | Effect of Adding Fentanyl to Bupivacaine on Patients Undergoing Transurethral Resection of the Prostate with Spinal Anesthesia: A Clinical trial |
| title_fullStr | Effect of Adding Fentanyl to Bupivacaine on Patients Undergoing Transurethral Resection of the Prostate with Spinal Anesthesia: A Clinical trial |
| title_full_unstemmed | Effect of Adding Fentanyl to Bupivacaine on Patients Undergoing Transurethral Resection of the Prostate with Spinal Anesthesia: A Clinical trial |
| title_short | Effect of Adding Fentanyl to Bupivacaine on Patients Undergoing Transurethral Resection of the Prostate with Spinal Anesthesia: A Clinical trial |
| title_sort | effect of adding fentanyl to bupivacaine on patients undergoing transurethral resection of the prostate with spinal anesthesia a clinical trial |
| topic | bupivacaine fentanyl spinal anesthesia mean arterial pressure hemodynamics transurethral resection of the prostate |
| url | http://jmums.mazums.ac.ir/article-1-14019-en.html |
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