Helicobacter pylori Infection is a Significant Factor Risk for Hyperhomocysteinemia in the Patients with Coronary Artery Disease
ABSTRACT This work aimed to determine whether seropositivity to Helicobacter pylori infection was an independent risk factor for hyperhomocysteinemia patients with cardiovascular disease. The H. pylori IgG, IgA and homocystein levels in 96 patients with cardiovascular disease and 64 participants fre...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Instituto de Tecnologia do Paraná (Tecpar)
2016-01-01
|
| Series: | Brazilian Archives of Biology and Technology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100304&lng=en&tlng=en |
| _version_ | 1819261169937940480 |
|---|---|
| author | Soudabeh Fallah Nariman Moradi Fadaei Reza Ahmadi Reza Tabatabei Azardokht Morteza Seifi |
| author_facet | Soudabeh Fallah Nariman Moradi Fadaei Reza Ahmadi Reza Tabatabei Azardokht Morteza Seifi |
| author_sort | Soudabeh Fallah |
| collection | DOAJ |
| description | ABSTRACT This work aimed to determine whether seropositivity to Helicobacter pylori infection was an independent risk factor for hyperhomocysteinemia patients with cardiovascular disease. The H. pylori IgG, IgA and homocystein levels in 96 patients with cardiovascular disease and 64 participants free of cardiovascular disease as control subjects were determined by ELISA assay. The results showed that seropositivity to H. pylori IgG and IgA levels of coronary artery disease (CAD)patients was significantly higher than the controls and CAD patients with H. pylori IgG and IgA negative antibodies. A significant correlation was found between the seropositivity to H. pylori IgG and homocysteine levels of CAD patients in comparison with the controls and CAD patients with seronegativity to H. pylori IgG and IgA (r=0.233, P= 0.019 ). The involvement of H. pylori infection in atherosclerosis process was based on the chronic inflammation, which might facilitate the CAD-related pathologies. The effect of the presence of H. pylori infection on homocysteine levels elevation in the CAD patients (as a risk factor independent of other traditional factors) was remarkable. |
| first_indexed | 2024-12-23T19:37:32Z |
| format | Article |
| id | doaj.art-5ddbca48e68143bb8885a1f9859dfc3e |
| institution | Directory Open Access Journal |
| issn | 1678-4324 |
| language | English |
| last_indexed | 2024-12-23T19:37:32Z |
| publishDate | 2016-01-01 |
| publisher | Instituto de Tecnologia do Paraná (Tecpar) |
| record_format | Article |
| series | Brazilian Archives of Biology and Technology |
| spelling | doaj.art-5ddbca48e68143bb8885a1f9859dfc3e2022-12-21T17:33:45ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1678-43242016-01-0159010.1590/1678-4324-2016150509S1516-89132016000100304Helicobacter pylori Infection is a Significant Factor Risk for Hyperhomocysteinemia in the Patients with Coronary Artery DiseaseSoudabeh FallahNariman MoradiFadaei RezaAhmadi RezaTabatabei AzardokhtMorteza SeifiABSTRACT This work aimed to determine whether seropositivity to Helicobacter pylori infection was an independent risk factor for hyperhomocysteinemia patients with cardiovascular disease. The H. pylori IgG, IgA and homocystein levels in 96 patients with cardiovascular disease and 64 participants free of cardiovascular disease as control subjects were determined by ELISA assay. The results showed that seropositivity to H. pylori IgG and IgA levels of coronary artery disease (CAD)patients was significantly higher than the controls and CAD patients with H. pylori IgG and IgA negative antibodies. A significant correlation was found between the seropositivity to H. pylori IgG and homocysteine levels of CAD patients in comparison with the controls and CAD patients with seronegativity to H. pylori IgG and IgA (r=0.233, P= 0.019 ). The involvement of H. pylori infection in atherosclerosis process was based on the chronic inflammation, which might facilitate the CAD-related pathologies. The effect of the presence of H. pylori infection on homocysteine levels elevation in the CAD patients (as a risk factor independent of other traditional factors) was remarkable.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100304&lng=en&tlng=enCardiovascular diseaseELISA assayhomocysteineHelicobacter pylori |
| spellingShingle | Soudabeh Fallah Nariman Moradi Fadaei Reza Ahmadi Reza Tabatabei Azardokht Morteza Seifi Helicobacter pylori Infection is a Significant Factor Risk for Hyperhomocysteinemia in the Patients with Coronary Artery Disease Brazilian Archives of Biology and Technology Cardiovascular disease ELISA assay homocysteine Helicobacter pylori |
| title | Helicobacter pylori Infection is a Significant Factor Risk for Hyperhomocysteinemia in the Patients with Coronary Artery Disease |
| title_full | Helicobacter pylori Infection is a Significant Factor Risk for Hyperhomocysteinemia in the Patients with Coronary Artery Disease |
| title_fullStr | Helicobacter pylori Infection is a Significant Factor Risk for Hyperhomocysteinemia in the Patients with Coronary Artery Disease |
| title_full_unstemmed | Helicobacter pylori Infection is a Significant Factor Risk for Hyperhomocysteinemia in the Patients with Coronary Artery Disease |
| title_short | Helicobacter pylori Infection is a Significant Factor Risk for Hyperhomocysteinemia in the Patients with Coronary Artery Disease |
| title_sort | helicobacter pylori infection is a significant factor risk for hyperhomocysteinemia in the patients with coronary artery disease |
| topic | Cardiovascular disease ELISA assay homocysteine Helicobacter pylori |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100304&lng=en&tlng=en |
| work_keys_str_mv | AT soudabehfallah helicobacterpyloriinfectionisasignificantfactorriskforhyperhomocysteinemiainthepatientswithcoronaryarterydisease AT narimanmoradi helicobacterpyloriinfectionisasignificantfactorriskforhyperhomocysteinemiainthepatientswithcoronaryarterydisease AT fadaeireza helicobacterpyloriinfectionisasignificantfactorriskforhyperhomocysteinemiainthepatientswithcoronaryarterydisease AT ahmadireza helicobacterpyloriinfectionisasignificantfactorriskforhyperhomocysteinemiainthepatientswithcoronaryarterydisease AT tabatabeiazardokht helicobacterpyloriinfectionisasignificantfactorriskforhyperhomocysteinemiainthepatientswithcoronaryarterydisease AT mortezaseifi helicobacterpyloriinfectionisasignificantfactorriskforhyperhomocysteinemiainthepatientswithcoronaryarterydisease |