Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia
The prevalence of neurological syndromes associated with antibodies to glutamic acid decarboxylase is increasing. While cognitive impairment is a common feature of this condition, it seldom emerges as the primary symptom. In this study, we discuss a case of refractory dementia associated with the gl...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1254981/full |
| _version_ | 1797655982631813120 |
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| author | Caio César Diniz Disserol Caio César Diniz Disserol Dora Pedroso Kowacs Samir Kanaan Nabhan Hélio Afonso Ghizoni Teive Pedro André Kowacs Pedro André Kowacs |
| author_facet | Caio César Diniz Disserol Caio César Diniz Disserol Dora Pedroso Kowacs Samir Kanaan Nabhan Hélio Afonso Ghizoni Teive Pedro André Kowacs Pedro André Kowacs |
| author_sort | Caio César Diniz Disserol |
| collection | DOAJ |
| description | The prevalence of neurological syndromes associated with antibodies to glutamic acid decarboxylase is increasing. While cognitive impairment is a common feature of this condition, it seldom emerges as the primary symptom. In this study, we discuss a case of refractory dementia associated with the glutamic acid decarboxylase spectrum disorder. Interestingly, this case showed a favorable outcome following autologous hematopoietic stem cell transplantation. We also provide an in-depth review of the current literature on the use of this therapeutic approach for the treatment of this disease. |
| first_indexed | 2024-03-11T17:23:39Z |
| format | Article |
| id | doaj.art-5dde13c27e5f43a49d08a1e8f8a044f4 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-11T17:23:39Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-5dde13c27e5f43a49d08a1e8f8a044f42023-10-19T08:06:14ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-10-011410.3389/fneur.2023.12549811254981Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementiaCaio César Diniz Disserol0Caio César Diniz Disserol1Dora Pedroso Kowacs2Samir Kanaan Nabhan3Hélio Afonso Ghizoni Teive4Pedro André Kowacs5Pedro André Kowacs6Department of Neurology, Instituto de Neurologia de Curitiba, Curitiba, BrazilDepartment of Neurology, Complexo do Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, BrazilDepartment of Neurology, Instituto de Neurologia de Curitiba, Curitiba, BrazilBlood and Marrow Transplantation Program, Hospital de Clínicas, Federal University of Paraná, Curitiba, BrazilDepartment of Neurology, Complexo do Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, BrazilDepartment of Neurology, Instituto de Neurologia de Curitiba, Curitiba, BrazilDepartment of Neurology, Complexo do Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, BrazilThe prevalence of neurological syndromes associated with antibodies to glutamic acid decarboxylase is increasing. While cognitive impairment is a common feature of this condition, it seldom emerges as the primary symptom. In this study, we discuss a case of refractory dementia associated with the glutamic acid decarboxylase spectrum disorder. Interestingly, this case showed a favorable outcome following autologous hematopoietic stem cell transplantation. We also provide an in-depth review of the current literature on the use of this therapeutic approach for the treatment of this disease.https://www.frontiersin.org/articles/10.3389/fneur.2023.1254981/fullautoimmune diseases of the nervous systemdementiaencephalitisglutamic acid decarboxylaseneurocognitive disorders |
| spellingShingle | Caio César Diniz Disserol Caio César Diniz Disserol Dora Pedroso Kowacs Samir Kanaan Nabhan Hélio Afonso Ghizoni Teive Pedro André Kowacs Pedro André Kowacs Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia Frontiers in Neurology autoimmune diseases of the nervous system dementia encephalitis glutamic acid decarboxylase neurocognitive disorders |
| title | Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia |
| title_full | Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia |
| title_fullStr | Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia |
| title_full_unstemmed | Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia |
| title_short | Case report: Successful autologous hematopoietic stem cell transplantation in a patient with GAD antibody-spectrum disorder with rapidly progressive dementia |
| title_sort | case report successful autologous hematopoietic stem cell transplantation in a patient with gad antibody spectrum disorder with rapidly progressive dementia |
| topic | autoimmune diseases of the nervous system dementia encephalitis glutamic acid decarboxylase neurocognitive disorders |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1254981/full |
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