Antibiotics Prescribing in Intensive Care Settings during the COVID-19 Era: A Systematic Review
The prevalence of patients admitted to intensive care units (ICUs) with SARS-CoV-2 infection who were prescribed antibiotics is undetermined and might contribute to the increased global antibiotic resistance. This systematic review evaluates the prevalence of antibiotic prescribing in patients admit...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-08-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/10/8/935 |
| _version_ | 1797524906841210880 |
|---|---|
| author | Lubna I. Abu-Rub Hana A. Abdelrahman Al-Reem A. Johar Hashim A. Alhussain Hamad Abdel Hadi Nahla O. Eltai |
| author_facet | Lubna I. Abu-Rub Hana A. Abdelrahman Al-Reem A. Johar Hashim A. Alhussain Hamad Abdel Hadi Nahla O. Eltai |
| author_sort | Lubna I. Abu-Rub |
| collection | DOAJ |
| description | The prevalence of patients admitted to intensive care units (ICUs) with SARS-CoV-2 infection who were prescribed antibiotics is undetermined and might contribute to the increased global antibiotic resistance. This systematic review evaluates the prevalence of antibiotic prescribing in patients admitted to ICUs with SARS-CoV-2 infection using PRISMA guidelines. We searched and scrutinized results from PubMed and ScienceDirect databases for published literature restricted to the English language up to 11 May 2021. In addition, we included observational studies of humans with laboratory-confirmed SARS-CoV-2 infection, clinical characteristics, and antibiotics prescribed for ICU patients with SARS-CoV-2 infections. A total of 361 studies were identified, but only 38 were included in the final analysis. Antibiotic prescribing data were available from 2715 patients, of which prevalence of 71% was reported in old age patients with a mean age of 62.7 years. From the reported studies, third generation cephalosporin had the highest frequency amongst reviewed studies (36.8%) followed by azithromycin (34.2%). The estimated bacterial infection in 12 reported studies was 30.8% produced by 15 different bacterial species, and <i>S. aureus</i> recorded the highest bacterial infection (75%). The fundamental outcomes were the prevalence of ICU COVID-19 patients prescribed antibiotics stratified by age, type of antibiotics prescribed, and the presence of co-infections and comorbidities. In conclusion, more than half of ICU patients with SARS-CoV-2 infection received antibiotics, and prescribing is significantly higher than the estimated frequency of identified bacterial co-infection. |
| first_indexed | 2024-03-10T09:03:16Z |
| format | Article |
| id | doaj.art-5ddf87de9a4349788280207648fa6063 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T09:03:16Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-5ddf87de9a4349788280207648fa60632023-11-22T06:33:30ZengMDPI AGAntibiotics2079-63822021-08-0110893510.3390/antibiotics10080935Antibiotics Prescribing in Intensive Care Settings during the COVID-19 Era: A Systematic ReviewLubna I. Abu-Rub0Hana A. Abdelrahman1Al-Reem A. Johar2Hashim A. Alhussain3Hamad Abdel Hadi4Nahla O. Eltai5Biomedical Research Center, Qatar University, Doha 2713, QatarBiomedical Research Center, Qatar University, Doha 2713, QatarBarzan Holdings, Doha 7178, QatarBiomedical Research Center, Qatar University, Doha 2713, QatarCommunicable Diseases Centre, Infectious Disease Division, Hamad Medical Corporation, Doha 3050, QatarBiomedical Research Center, Qatar University, Doha 2713, QatarThe prevalence of patients admitted to intensive care units (ICUs) with SARS-CoV-2 infection who were prescribed antibiotics is undetermined and might contribute to the increased global antibiotic resistance. This systematic review evaluates the prevalence of antibiotic prescribing in patients admitted to ICUs with SARS-CoV-2 infection using PRISMA guidelines. We searched and scrutinized results from PubMed and ScienceDirect databases for published literature restricted to the English language up to 11 May 2021. In addition, we included observational studies of humans with laboratory-confirmed SARS-CoV-2 infection, clinical characteristics, and antibiotics prescribed for ICU patients with SARS-CoV-2 infections. A total of 361 studies were identified, but only 38 were included in the final analysis. Antibiotic prescribing data were available from 2715 patients, of which prevalence of 71% was reported in old age patients with a mean age of 62.7 years. From the reported studies, third generation cephalosporin had the highest frequency amongst reviewed studies (36.8%) followed by azithromycin (34.2%). The estimated bacterial infection in 12 reported studies was 30.8% produced by 15 different bacterial species, and <i>S. aureus</i> recorded the highest bacterial infection (75%). The fundamental outcomes were the prevalence of ICU COVID-19 patients prescribed antibiotics stratified by age, type of antibiotics prescribed, and the presence of co-infections and comorbidities. In conclusion, more than half of ICU patients with SARS-CoV-2 infection received antibiotics, and prescribing is significantly higher than the estimated frequency of identified bacterial co-infection.https://www.mdpi.com/2079-6382/10/8/935COVID-19SARS-CoV-2antibioticantibiotic prescriptionICUbacterial co-infections |
| spellingShingle | Lubna I. Abu-Rub Hana A. Abdelrahman Al-Reem A. Johar Hashim A. Alhussain Hamad Abdel Hadi Nahla O. Eltai Antibiotics Prescribing in Intensive Care Settings during the COVID-19 Era: A Systematic Review Antibiotics COVID-19 SARS-CoV-2 antibiotic antibiotic prescription ICU bacterial co-infections |
| title | Antibiotics Prescribing in Intensive Care Settings during the COVID-19 Era: A Systematic Review |
| title_full | Antibiotics Prescribing in Intensive Care Settings during the COVID-19 Era: A Systematic Review |
| title_fullStr | Antibiotics Prescribing in Intensive Care Settings during the COVID-19 Era: A Systematic Review |
| title_full_unstemmed | Antibiotics Prescribing in Intensive Care Settings during the COVID-19 Era: A Systematic Review |
| title_short | Antibiotics Prescribing in Intensive Care Settings during the COVID-19 Era: A Systematic Review |
| title_sort | antibiotics prescribing in intensive care settings during the covid 19 era a systematic review |
| topic | COVID-19 SARS-CoV-2 antibiotic antibiotic prescription ICU bacterial co-infections |
| url | https://www.mdpi.com/2079-6382/10/8/935 |
| work_keys_str_mv | AT lubnaiaburub antibioticsprescribinginintensivecaresettingsduringthecovid19eraasystematicreview AT hanaaabdelrahman antibioticsprescribinginintensivecaresettingsduringthecovid19eraasystematicreview AT alreemajohar antibioticsprescribinginintensivecaresettingsduringthecovid19eraasystematicreview AT hashimaalhussain antibioticsprescribinginintensivecaresettingsduringthecovid19eraasystematicreview AT hamadabdelhadi antibioticsprescribinginintensivecaresettingsduringthecovid19eraasystematicreview AT nahlaoeltai antibioticsprescribinginintensivecaresettingsduringthecovid19eraasystematicreview |