Analysis in silico of the functional interaction between WNT5A and YAP/TEAD signaling in cancer
To date, most data regarding the crosstalk between the Wnt signaling pathway and the YAP/TAZ transcriptional coactivators focuses on the Wnt/β-catenin branch of the pathway. In contrast, the relationship between the non-canonical Wnt pathway and YAP/TAZ remains significantly less explored. Wnt5a is...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2021-02-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/10869.pdf |
| _version_ | 1797418460740845568 |
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| author | Pablo Astudillo |
| author_facet | Pablo Astudillo |
| author_sort | Pablo Astudillo |
| collection | DOAJ |
| description | To date, most data regarding the crosstalk between the Wnt signaling pathway and the YAP/TAZ transcriptional coactivators focuses on the Wnt/β-catenin branch of the pathway. In contrast, the relationship between the non-canonical Wnt pathway and YAP/TAZ remains significantly less explored. Wnt5a is usually regarded as a prototypical non-canonical Wnt ligand, and its expression has been related to cancer progression. On the other hand, YAP/TAZ transcriptional coactivators act in concert with TEAD transcription factors to control gene expression. Although one article has shown previously that WNT5A is a YAP/TEAD target gene, there is a need for further evidence supporting this regulatory relationship, because a possible YAP/Wnt5a regulatory circuit might have profound implications for cancer biology. This article analyzes publicly available ChIP-Seq, gene expression, and protein expression data to explore this relationship, and shows that WNT5A might be a YAP/TEAD target gene in several contexts. Moreover, Wnt5a and YAP expression are significantly correlated in specific cancer types, suggesting that the crosstalk between YAP/TAZ and the Wnt pathway is more intricate than previously thought. |
| first_indexed | 2024-03-09T06:32:57Z |
| format | Article |
| id | doaj.art-5ddfb9d9a20e44278fe8281327346017 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:32:57Z |
| publishDate | 2021-02-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-5ddfb9d9a20e44278fe82813273460172023-12-03T11:02:39ZengPeerJ Inc.PeerJ2167-83592021-02-019e1086910.7717/peerj.10869Analysis in silico of the functional interaction between WNT5A and YAP/TEAD signaling in cancerPablo Astudillo0Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Santiago, ChileTo date, most data regarding the crosstalk between the Wnt signaling pathway and the YAP/TAZ transcriptional coactivators focuses on the Wnt/β-catenin branch of the pathway. In contrast, the relationship between the non-canonical Wnt pathway and YAP/TAZ remains significantly less explored. Wnt5a is usually regarded as a prototypical non-canonical Wnt ligand, and its expression has been related to cancer progression. On the other hand, YAP/TAZ transcriptional coactivators act in concert with TEAD transcription factors to control gene expression. Although one article has shown previously that WNT5A is a YAP/TEAD target gene, there is a need for further evidence supporting this regulatory relationship, because a possible YAP/Wnt5a regulatory circuit might have profound implications for cancer biology. This article analyzes publicly available ChIP-Seq, gene expression, and protein expression data to explore this relationship, and shows that WNT5A might be a YAP/TEAD target gene in several contexts. Moreover, Wnt5a and YAP expression are significantly correlated in specific cancer types, suggesting that the crosstalk between YAP/TAZ and the Wnt pathway is more intricate than previously thought.https://peerj.com/articles/10869.pdfWnt5aYAPCancerSignaling pathwaysTranscription factors |
| spellingShingle | Pablo Astudillo Analysis in silico of the functional interaction between WNT5A and YAP/TEAD signaling in cancer PeerJ Wnt5a YAP Cancer Signaling pathways Transcription factors |
| title | Analysis in silico of the functional interaction between WNT5A and YAP/TEAD signaling in cancer |
| title_full | Analysis in silico of the functional interaction between WNT5A and YAP/TEAD signaling in cancer |
| title_fullStr | Analysis in silico of the functional interaction between WNT5A and YAP/TEAD signaling in cancer |
| title_full_unstemmed | Analysis in silico of the functional interaction between WNT5A and YAP/TEAD signaling in cancer |
| title_short | Analysis in silico of the functional interaction between WNT5A and YAP/TEAD signaling in cancer |
| title_sort | analysis in silico of the functional interaction between wnt5a and yap tead signaling in cancer |
| topic | Wnt5a YAP Cancer Signaling pathways Transcription factors |
| url | https://peerj.com/articles/10869.pdf |
| work_keys_str_mv | AT pabloastudillo analysisinsilicoofthefunctionalinteractionbetweenwnt5aandyapteadsignalingincancer |