| Summary: | <p class="orbitalabstract">Novel series of ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5<em>H</em>-thiazolo[3,2-a] pyrimidine-6-carboxylate (<strong>4a–g</strong>) heterocyclic compounds have been synthesized in a one-pot reaction under solvent-free conditions from 4-(naphthalen-2-yl)thiazol-2-amine (<strong>1</strong>), various aromatic benzaldehyde (<strong>2a–g</strong>) and ethylacetoacetate (<strong>3</strong>). All the synthesized compounds were duly characterized by physic chemical analysis and various spectrometric technique viz., NMR, CMR and FT–IR spectral features. Compounds <strong>4a–g</strong> were screened for their in vitro antibacterial activity against Gram-positive bacterial strains (<em>Bacillus subtilis</em> and <em>Staphylococcus aureus</em>) and Gram-negative bacterial strains (<em>Salmonella typhimurium </em>and <em>Escherichia coli</em>). Compounds <strong>4a–g</strong> were also examined for antifungal activity against different fungal strains, i.e. P<em>enicillium expansum</em>, <em>Botryodiplodia theobromae</em>, <em>Nigrospora sp</em>., and <em>Trichothesium sp</em>.</p><p class="orbitalabstract"> </p><p class="orbitalabstract">DOI: <a href="http://dx.doi.org/10.17807/orbital.v9i4.879">http://dx.doi.org/10.17807/orbital.v9i4.879</a></p>
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