Synthetic and Biological Studies of Ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives
<p class="orbitalabstract">Novel series of ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5<em>H</em>-thiazolo[3,2-a] pyrimidine-6-carboxylate (<strong>4a–g</strong>) heterocyclic compounds have been synthesized in a one-pot reaction under solvent-free conditions...
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| Format: | Article |
| Language: | English |
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Universidade Federal de Mato Grosso do Sul
2017-10-01
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| Series: | Orbital: The Electronic Journal of Chemistry |
| Subjects: | |
| Online Access: | http://orbital.ufms.br/index.php/Chemistry/article/view/879 |
| _version_ | 1818294173195829248 |
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| author | Yogesh S. Patel Kandarp H. Patel |
| author_facet | Yogesh S. Patel Kandarp H. Patel |
| author_sort | Yogesh S. Patel |
| collection | DOAJ |
| description | <p class="orbitalabstract">Novel series of ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5<em>H</em>-thiazolo[3,2-a] pyrimidine-6-carboxylate (<strong>4a–g</strong>) heterocyclic compounds have been synthesized in a one-pot reaction under solvent-free conditions from 4-(naphthalen-2-yl)thiazol-2-amine (<strong>1</strong>), various aromatic benzaldehyde (<strong>2a–g</strong>) and ethylacetoacetate (<strong>3</strong>). All the synthesized compounds were duly characterized by physic chemical analysis and various spectrometric technique viz., NMR, CMR and FT–IR spectral features. Compounds <strong>4a–g</strong> were screened for their in vitro antibacterial activity against Gram-positive bacterial strains (<em>Bacillus subtilis</em> and <em>Staphylococcus aureus</em>) and Gram-negative bacterial strains (<em>Salmonella typhimurium </em>and <em>Escherichia coli</em>). Compounds <strong>4a–g</strong> were also examined for antifungal activity against different fungal strains, i.e. P<em>enicillium expansum</em>, <em>Botryodiplodia theobromae</em>, <em>Nigrospora sp</em>., and <em>Trichothesium sp</em>.</p><p class="orbitalabstract"> </p><p class="orbitalabstract">DOI: <a href="http://dx.doi.org/10.17807/orbital.v9i4.879">http://dx.doi.org/10.17807/orbital.v9i4.879</a></p> |
| first_indexed | 2024-12-13T03:27:32Z |
| format | Article |
| id | doaj.art-5de073da95254dc5879aa8ad4b567a77 |
| institution | Directory Open Access Journal |
| issn | 1984-6428 |
| language | English |
| last_indexed | 2024-12-13T03:27:32Z |
| publishDate | 2017-10-01 |
| publisher | Universidade Federal de Mato Grosso do Sul |
| record_format | Article |
| series | Orbital: The Electronic Journal of Chemistry |
| spelling | doaj.art-5de073da95254dc5879aa8ad4b567a772022-12-22T00:01:14ZengUniversidade Federal de Mato Grosso do SulOrbital: The Electronic Journal of Chemistry1984-64282017-10-019421922410.17807/orbital.v9i4.879434Synthetic and Biological Studies of Ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate DerivativesYogesh S. Patel0Kandarp H. Patel1GOVERNMENT SCIENCE COLLEGE, GANDHINAGARDepartment of Research and Development, Adventus Laboratories (India) Pvt. Ltd. 495/7–8, GIDC, Makarpura, Vadodara-390010, Gujarat, INDIA<p class="orbitalabstract">Novel series of ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5<em>H</em>-thiazolo[3,2-a] pyrimidine-6-carboxylate (<strong>4a–g</strong>) heterocyclic compounds have been synthesized in a one-pot reaction under solvent-free conditions from 4-(naphthalen-2-yl)thiazol-2-amine (<strong>1</strong>), various aromatic benzaldehyde (<strong>2a–g</strong>) and ethylacetoacetate (<strong>3</strong>). All the synthesized compounds were duly characterized by physic chemical analysis and various spectrometric technique viz., NMR, CMR and FT–IR spectral features. Compounds <strong>4a–g</strong> were screened for their in vitro antibacterial activity against Gram-positive bacterial strains (<em>Bacillus subtilis</em> and <em>Staphylococcus aureus</em>) and Gram-negative bacterial strains (<em>Salmonella typhimurium </em>and <em>Escherichia coli</em>). Compounds <strong>4a–g</strong> were also examined for antifungal activity against different fungal strains, i.e. P<em>enicillium expansum</em>, <em>Botryodiplodia theobromae</em>, <em>Nigrospora sp</em>., and <em>Trichothesium sp</em>.</p><p class="orbitalabstract"> </p><p class="orbitalabstract">DOI: <a href="http://dx.doi.org/10.17807/orbital.v9i4.879">http://dx.doi.org/10.17807/orbital.v9i4.879</a></p>http://orbital.ufms.br/index.php/Chemistry/article/view/879antimicrobial activitysolvent-freeone-pot synthesisthiazolo[3,2-a]pyrimidine |
| spellingShingle | Yogesh S. Patel Kandarp H. Patel Synthetic and Biological Studies of Ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives Orbital: The Electronic Journal of Chemistry antimicrobial activity solvent-free one-pot synthesis thiazolo[3,2-a]pyrimidine |
| title | Synthetic and Biological Studies of Ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives |
| title_full | Synthetic and Biological Studies of Ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives |
| title_fullStr | Synthetic and Biological Studies of Ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives |
| title_full_unstemmed | Synthetic and Biological Studies of Ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives |
| title_short | Synthetic and Biological Studies of Ethyl-7-methyl-3-(naphthalen-2-yl)-5-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate Derivatives |
| title_sort | synthetic and biological studies of ethyl 7 methyl 3 naphthalen 2 yl 5 phenyl 5h thiazolo 3 2 a pyrimidine 6 carboxylate derivatives |
| topic | antimicrobial activity solvent-free one-pot synthesis thiazolo[3,2-a]pyrimidine |
| url | http://orbital.ufms.br/index.php/Chemistry/article/view/879 |
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