Efficacy of Erymicin 200 Injections for Reducing <i>Renibacterium salmoninarum</i> and Controlling Vertical Transmission in an Inland Rainbow Trout Brood Stock
Bacterial Kidney Disease, caused by <i>Renibacterium salmoninarum</i> (<i>Rs</i>), is widespread and can cause significant mortality at most life stages in infected salmonids. <i>Rs</i> is commonly found in inland trout, which can be carriers of the bacterium. Let...
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MDPI AG
2020-07-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/7/547 |
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| author | Eric R. Fetherman Brad Neuschwanger Tracy Davis Colby L. Wells April Kraft |
| author_facet | Eric R. Fetherman Brad Neuschwanger Tracy Davis Colby L. Wells April Kraft |
| author_sort | Eric R. Fetherman |
| collection | DOAJ |
| description | Bacterial Kidney Disease, caused by <i>Renibacterium salmoninarum</i> (<i>Rs</i>), is widespread and can cause significant mortality at most life stages in infected salmonids. <i>Rs</i> is commonly found in inland trout, which can be carriers of the bacterium. Lethal spawns can be used to control vertical transmission to progeny through the culling of eggs from infected parents, but can be costly, time-consuming, and can negatively impact important and rare brood stocks. Erymicin 200 is an Investigational New Animal Drug (INAD) intended to reduce <i>Rs</i> levels in hatchery brood stocks and control vertical transmission to progeny. We tested the efficacy of Erymicin 200 injections in a positive, hatchery-resident rainbow trout (<i>Oncorhynchus mykiss</i>) brood stock in Colorado, USA. Brood fish age two and three were injected with 25 mg per kg of body weight Erymicin 200 three times prior to spawning. Erymicin 200 was effective in reducing <i>Rs</i> to below detectable levels in treated fish. However, both negative treated and control brood fish produced positive progeny, suggesting that Erymicin 200 did not prevent the vertical transmission of <i>Rs.</i> |
| first_indexed | 2024-03-10T18:38:28Z |
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| id | doaj.art-5de07ca14c89475cb4175689cbcefa70 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T18:38:28Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-5de07ca14c89475cb4175689cbcefa702023-11-20T06:03:55ZengMDPI AGPathogens2076-08172020-07-019754710.3390/pathogens9070547Efficacy of Erymicin 200 Injections for Reducing <i>Renibacterium salmoninarum</i> and Controlling Vertical Transmission in an Inland Rainbow Trout Brood StockEric R. Fetherman0Brad Neuschwanger1Tracy Davis2Colby L. Wells3April Kraft4Colorado Parks and Wildlife, Aquatic Wildlife Research Section, 317 West Prospect Road, Fort Collins, CO 80526, USAColorado Parks and Wildlife, Bellvue Fish Research Hatchery, 5500 West County Road 50E, Bellvue, CO 80512, USAColorado Parks and Wildlife, Bellvue Fish Research Hatchery, 5500 West County Road 50E, Bellvue, CO 80512, USAColorado Parks and Wildlife, Aquatic Animal Health Laboratory, 122 East Edison Street, Brush, CO 80723, USAColorado Parks and Wildlife, Aquatic Animal Health Laboratory, 122 East Edison Street, Brush, CO 80723, USABacterial Kidney Disease, caused by <i>Renibacterium salmoninarum</i> (<i>Rs</i>), is widespread and can cause significant mortality at most life stages in infected salmonids. <i>Rs</i> is commonly found in inland trout, which can be carriers of the bacterium. Lethal spawns can be used to control vertical transmission to progeny through the culling of eggs from infected parents, but can be costly, time-consuming, and can negatively impact important and rare brood stocks. Erymicin 200 is an Investigational New Animal Drug (INAD) intended to reduce <i>Rs</i> levels in hatchery brood stocks and control vertical transmission to progeny. We tested the efficacy of Erymicin 200 injections in a positive, hatchery-resident rainbow trout (<i>Oncorhynchus mykiss</i>) brood stock in Colorado, USA. Brood fish age two and three were injected with 25 mg per kg of body weight Erymicin 200 three times prior to spawning. Erymicin 200 was effective in reducing <i>Rs</i> to below detectable levels in treated fish. However, both negative treated and control brood fish produced positive progeny, suggesting that Erymicin 200 did not prevent the vertical transmission of <i>Rs.</i>https://www.mdpi.com/2076-0817/9/7/547rainbow trout<i>Oncorhynchus mykiss</i>brood stock<i>Renibacterium salmoninarum</i>bacterial kidney diseaseantibiotics |
| spellingShingle | Eric R. Fetherman Brad Neuschwanger Tracy Davis Colby L. Wells April Kraft Efficacy of Erymicin 200 Injections for Reducing <i>Renibacterium salmoninarum</i> and Controlling Vertical Transmission in an Inland Rainbow Trout Brood Stock Pathogens rainbow trout <i>Oncorhynchus mykiss</i> brood stock <i>Renibacterium salmoninarum</i> bacterial kidney disease antibiotics |
| title | Efficacy of Erymicin 200 Injections for Reducing <i>Renibacterium salmoninarum</i> and Controlling Vertical Transmission in an Inland Rainbow Trout Brood Stock |
| title_full | Efficacy of Erymicin 200 Injections for Reducing <i>Renibacterium salmoninarum</i> and Controlling Vertical Transmission in an Inland Rainbow Trout Brood Stock |
| title_fullStr | Efficacy of Erymicin 200 Injections for Reducing <i>Renibacterium salmoninarum</i> and Controlling Vertical Transmission in an Inland Rainbow Trout Brood Stock |
| title_full_unstemmed | Efficacy of Erymicin 200 Injections for Reducing <i>Renibacterium salmoninarum</i> and Controlling Vertical Transmission in an Inland Rainbow Trout Brood Stock |
| title_short | Efficacy of Erymicin 200 Injections for Reducing <i>Renibacterium salmoninarum</i> and Controlling Vertical Transmission in an Inland Rainbow Trout Brood Stock |
| title_sort | efficacy of erymicin 200 injections for reducing i renibacterium salmoninarum i and controlling vertical transmission in an inland rainbow trout brood stock |
| topic | rainbow trout <i>Oncorhynchus mykiss</i> brood stock <i>Renibacterium salmoninarum</i> bacterial kidney disease antibiotics |
| url | https://www.mdpi.com/2076-0817/9/7/547 |
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