Cellular proliferation markers in peripheral and central fibromas: a comparative study
Objective: To perform a comparative study of the cellular proliferation in the peripheral and central fibromas. Material and Methods: Immunohistochemistry for PCNA and the AgNOR technique were performed in 9 cases of peripheral odontogenic fibroma (POF), in 4 cases of odontogenic fibroma (OdF), in...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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University of São Paulo
2013-04-01
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| Series: | Journal of Applied Oral Science |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572013000200106 |
| _version_ | 1818884837557141504 |
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| author | Bruna Gonçalves Garcia Patrícia Carlos Caldeira Aline Cristina Batista Rodrigues Johann Suzana Cantanhede Orsini Machado de Sousa Marcelo Vidigal Caliari Maria Auxiliadora Vieira do Carmo Ricardo Alves Mesquita |
| author_facet | Bruna Gonçalves Garcia Patrícia Carlos Caldeira Aline Cristina Batista Rodrigues Johann Suzana Cantanhede Orsini Machado de Sousa Marcelo Vidigal Caliari Maria Auxiliadora Vieira do Carmo Ricardo Alves Mesquita |
| author_sort | Bruna Gonçalves Garcia |
| collection | DOAJ |
| description | Objective: To perform a comparative study of the cellular proliferation in the peripheral and central fibromas. Material and Methods: Immunohistochemistry for PCNA and the AgNOR technique were performed in 9 cases of peripheral odontogenic fibroma (POF), in 4 cases of odontogenic fibroma (OdF), in 8 cases of peripheral ossifying fibroma (PEOF) and 7 cases of ossifying fibroma (OsF). The Kruskal-Wallis and Mann-Whitney tests were used for the statistical analyses. Results: Mesenchymal component of the central lesions presented a higher mean number of AgNOR per nucleus and PCNA index than did the peripheral lesions (P≤0.05). The mean number of AgNOR per nucleus in the epithelial component proved to be higher in the OdF than in the POF (P≤0.05). The mesenchymal and epithelial components presented similar mean numbers of AgNOR per nucleus and PCNA index in the OdF, as well as a similar mean number of AgNOR per nucleus in the POF. Conclusions: The mesenchymal component may well play a role in the differences between the biological behaviour of the central lesions as compared to the peripheral lesions. Moreover, considering that the epithelial and mesenchymal components in odontogenic fibromas presented a similar proliferation index, more research is warranted to understand the true role of the epithelial components, which are believed to be inactive in nature, as well as in the development and biological behaviour of these lesions. |
| first_indexed | 2024-12-19T15:55:54Z |
| format | Article |
| id | doaj.art-5de0f8653e2a4d7bba1095911c04a09f |
| institution | Directory Open Access Journal |
| issn | 1678-7757 1678-7765 |
| language | English |
| last_indexed | 2024-12-19T15:55:54Z |
| publishDate | 2013-04-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Journal of Applied Oral Science |
| spelling | doaj.art-5de0f8653e2a4d7bba1095911c04a09f2022-12-21T20:15:05ZengUniversity of São PauloJournal of Applied Oral Science1678-77571678-77652013-04-01212106111Cellular proliferation markers in peripheral and central fibromas: a comparative studyBruna Gonçalves GarciaPatrícia Carlos CaldeiraAline Cristina Batista Rodrigues JohannSuzana Cantanhede Orsini Machado de SousaMarcelo Vidigal CaliariMaria Auxiliadora Vieira do CarmoRicardo Alves MesquitaObjective: To perform a comparative study of the cellular proliferation in the peripheral and central fibromas. Material and Methods: Immunohistochemistry for PCNA and the AgNOR technique were performed in 9 cases of peripheral odontogenic fibroma (POF), in 4 cases of odontogenic fibroma (OdF), in 8 cases of peripheral ossifying fibroma (PEOF) and 7 cases of ossifying fibroma (OsF). The Kruskal-Wallis and Mann-Whitney tests were used for the statistical analyses. Results: Mesenchymal component of the central lesions presented a higher mean number of AgNOR per nucleus and PCNA index than did the peripheral lesions (P≤0.05). The mean number of AgNOR per nucleus in the epithelial component proved to be higher in the OdF than in the POF (P≤0.05). The mesenchymal and epithelial components presented similar mean numbers of AgNOR per nucleus and PCNA index in the OdF, as well as a similar mean number of AgNOR per nucleus in the POF. Conclusions: The mesenchymal component may well play a role in the differences between the biological behaviour of the central lesions as compared to the peripheral lesions. Moreover, considering that the epithelial and mesenchymal components in odontogenic fibromas presented a similar proliferation index, more research is warranted to understand the true role of the epithelial components, which are believed to be inactive in nature, as well as in the development and biological behaviour of these lesions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572013000200106AgNORsOdontogenic tumoursOssifying fibromaPCNA |
| spellingShingle | Bruna Gonçalves Garcia Patrícia Carlos Caldeira Aline Cristina Batista Rodrigues Johann Suzana Cantanhede Orsini Machado de Sousa Marcelo Vidigal Caliari Maria Auxiliadora Vieira do Carmo Ricardo Alves Mesquita Cellular proliferation markers in peripheral and central fibromas: a comparative study Journal of Applied Oral Science AgNORs Odontogenic tumours Ossifying fibroma PCNA |
| title | Cellular proliferation markers in peripheral and central fibromas: a comparative study |
| title_full | Cellular proliferation markers in peripheral and central fibromas: a comparative study |
| title_fullStr | Cellular proliferation markers in peripheral and central fibromas: a comparative study |
| title_full_unstemmed | Cellular proliferation markers in peripheral and central fibromas: a comparative study |
| title_short | Cellular proliferation markers in peripheral and central fibromas: a comparative study |
| title_sort | cellular proliferation markers in peripheral and central fibromas a comparative study |
| topic | AgNORs Odontogenic tumours Ossifying fibroma PCNA |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572013000200106 |
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