Genome‐wide comparative identification and analysis of membrane‐FADS‐like superfamily genes in freshwater economic fishes
Membrane fatty acid desaturase (FADS)‐like superfamily proteins (FADSs) are essential for the synthesis of unsaturated fatty acids (UFAs). Recently, studies on FADS in fishes have mostly focused on marine species, and a comprehensive analysis of the FADS superfamily, including the FADS, stearoyl‐CoA...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/2211-5463.13594 |
| _version_ | 1797810919248494592 |
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| author | Yuru Zhang Junmei Zhang Kedi Gao Ronghua Lu Xianglin Cao Liping Yang Guoxing Nie |
| author_facet | Yuru Zhang Junmei Zhang Kedi Gao Ronghua Lu Xianglin Cao Liping Yang Guoxing Nie |
| author_sort | Yuru Zhang |
| collection | DOAJ |
| description | Membrane fatty acid desaturase (FADS)‐like superfamily proteins (FADSs) are essential for the synthesis of unsaturated fatty acids (UFAs). Recently, studies on FADS in fishes have mostly focused on marine species, and a comprehensive analysis of the FADS superfamily, including the FADS, stearoyl‐CoA desaturase (SCD), and sphingolipid delta 4‐desaturase (DEGS) families, in freshwater economic fishes is urgently required. To this end, we conducted a thorough analysis of the number, gene/protein structure, chromosomal location, gene linkage map, phylogeny, and expression of the FADS superfamily. We identified 156 FADSs genes in the genome of 27 representative species. Notably, FADS1 and SCD5 were lost in most freshwater fish and other teleosts. All FADSs proteins contain 4 transmembrane helices and 2–3 amphipathic α‐helices. FADSs in the same family are often linked on the same chromosome; moreover, FADS and SCD or DEGS are frequently collocated on the same chromosome. In addition, FADS, SCD, and DEGS family proteins share similar evolutionary patterns. Interestingly, FADS6, as a member of the FADS family, exhibits a similar gene structure and chromosome location to that of SCD family members, which may be the transitional form of FADS and SCD. This study shed light on the type, structure, and phylogenetic relationship of FADSs in freshwater fishes, offering a new perspective into the functional mechanism analysis of FADSs. |
| first_indexed | 2024-03-13T07:14:59Z |
| format | Article |
| id | doaj.art-5de2cd476e9849d8a2876948224c83d9 |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-03-13T07:14:59Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-5de2cd476e9849d8a2876948224c83d92023-06-05T08:21:04ZengWileyFEBS Open Bio2211-54632023-06-011361067108510.1002/2211-5463.13594Genome‐wide comparative identification and analysis of membrane‐FADS‐like superfamily genes in freshwater economic fishesYuru Zhang0Junmei Zhang1Kedi Gao2Ronghua Lu3Xianglin Cao4Liping Yang5Guoxing Nie6College of Fisheries Henan Normal University Xinxiang ChinaCollege of Fisheries Henan Normal University Xinxiang ChinaCollege of Fisheries Henan Normal University Xinxiang ChinaCollege of Fisheries Henan Normal University Xinxiang ChinaCollege of Fisheries Henan Normal University Xinxiang ChinaCollege of Fisheries Henan Normal University Xinxiang ChinaCollege of Fisheries Henan Normal University Xinxiang ChinaMembrane fatty acid desaturase (FADS)‐like superfamily proteins (FADSs) are essential for the synthesis of unsaturated fatty acids (UFAs). Recently, studies on FADS in fishes have mostly focused on marine species, and a comprehensive analysis of the FADS superfamily, including the FADS, stearoyl‐CoA desaturase (SCD), and sphingolipid delta 4‐desaturase (DEGS) families, in freshwater economic fishes is urgently required. To this end, we conducted a thorough analysis of the number, gene/protein structure, chromosomal location, gene linkage map, phylogeny, and expression of the FADS superfamily. We identified 156 FADSs genes in the genome of 27 representative species. Notably, FADS1 and SCD5 were lost in most freshwater fish and other teleosts. All FADSs proteins contain 4 transmembrane helices and 2–3 amphipathic α‐helices. FADSs in the same family are often linked on the same chromosome; moreover, FADS and SCD or DEGS are frequently collocated on the same chromosome. In addition, FADS, SCD, and DEGS family proteins share similar evolutionary patterns. Interestingly, FADS6, as a member of the FADS family, exhibits a similar gene structure and chromosome location to that of SCD family members, which may be the transitional form of FADS and SCD. This study shed light on the type, structure, and phylogenetic relationship of FADSs in freshwater fishes, offering a new perspective into the functional mechanism analysis of FADSs.https://doi.org/10.1002/2211-5463.13594FADSfreshwater economic fishesgene structurephylogenetic analysis |
| spellingShingle | Yuru Zhang Junmei Zhang Kedi Gao Ronghua Lu Xianglin Cao Liping Yang Guoxing Nie Genome‐wide comparative identification and analysis of membrane‐FADS‐like superfamily genes in freshwater economic fishes FEBS Open Bio FADS freshwater economic fishes gene structure phylogenetic analysis |
| title | Genome‐wide comparative identification and analysis of membrane‐FADS‐like superfamily genes in freshwater economic fishes |
| title_full | Genome‐wide comparative identification and analysis of membrane‐FADS‐like superfamily genes in freshwater economic fishes |
| title_fullStr | Genome‐wide comparative identification and analysis of membrane‐FADS‐like superfamily genes in freshwater economic fishes |
| title_full_unstemmed | Genome‐wide comparative identification and analysis of membrane‐FADS‐like superfamily genes in freshwater economic fishes |
| title_short | Genome‐wide comparative identification and analysis of membrane‐FADS‐like superfamily genes in freshwater economic fishes |
| title_sort | genome wide comparative identification and analysis of membrane fads like superfamily genes in freshwater economic fishes |
| topic | FADS freshwater economic fishes gene structure phylogenetic analysis |
| url | https://doi.org/10.1002/2211-5463.13594 |
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