Ectopic lipid metabolism in anterior pituitary dysfunction
Over the past decades, adapted lifestyle and dietary habits in industrialized countries have led to a progress of obesity and associated metabolic disorders. Concomitant insulin resistance and derangements in lipid metabolism foster the deposition of excess lipids in organs and tissues with limited...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2023-02-01
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Series: | Frontiers in Endocrinology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1075776/full |
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author | Clemens Baumgartner Martin Krššák Greisa Vila Michael Krebs Peter Wolf |
author_facet | Clemens Baumgartner Martin Krššák Greisa Vila Michael Krebs Peter Wolf |
author_sort | Clemens Baumgartner |
collection | DOAJ |
description | Over the past decades, adapted lifestyle and dietary habits in industrialized countries have led to a progress of obesity and associated metabolic disorders. Concomitant insulin resistance and derangements in lipid metabolism foster the deposition of excess lipids in organs and tissues with limited capacity of physiologic lipid storage. In organs pivotal for systemic metabolic homeostasis, this ectopic lipid content disturbs metabolic action, thereby promotes the progression of metabolic disease, and inherits a risk for cardiometabolic complications. Pituitary hormone syndromes are commonly associated with metabolic diseases. However, the impact on subcutaneous, visceral, and ectopic fat stores between disorders and their underlying hormonal axes is rather different, and the underlying pathophysiological pathways remain largely unknown. Pituitary disorders might influence ectopic lipid deposition indirectly by modulating lipid metabolism and insulin sensitivity, but also directly by organ specific hormonal effects on energy metabolism. In this review, we aim to I) provide information about the impact of pituitary disorders on ectopic fat stores, II) and to present up-to-date knowledge on potential pathophysiological mechanisms of hormone action in ectopic lipid metabolism. |
first_indexed | 2024-04-10T15:36:35Z |
format | Article |
id | doaj.art-5de3b30b56f84436a620a6b2ae3ccf69 |
institution | Directory Open Access Journal |
issn | 1664-2392 |
language | English |
last_indexed | 2024-04-10T15:36:35Z |
publishDate | 2023-02-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Endocrinology |
spelling | doaj.art-5de3b30b56f84436a620a6b2ae3ccf692023-02-13T05:33:22ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-02-011410.3389/fendo.2023.10757761075776Ectopic lipid metabolism in anterior pituitary dysfunctionClemens BaumgartnerMartin KrššákGreisa VilaMichael KrebsPeter WolfOver the past decades, adapted lifestyle and dietary habits in industrialized countries have led to a progress of obesity and associated metabolic disorders. Concomitant insulin resistance and derangements in lipid metabolism foster the deposition of excess lipids in organs and tissues with limited capacity of physiologic lipid storage. In organs pivotal for systemic metabolic homeostasis, this ectopic lipid content disturbs metabolic action, thereby promotes the progression of metabolic disease, and inherits a risk for cardiometabolic complications. Pituitary hormone syndromes are commonly associated with metabolic diseases. However, the impact on subcutaneous, visceral, and ectopic fat stores between disorders and their underlying hormonal axes is rather different, and the underlying pathophysiological pathways remain largely unknown. Pituitary disorders might influence ectopic lipid deposition indirectly by modulating lipid metabolism and insulin sensitivity, but also directly by organ specific hormonal effects on energy metabolism. In this review, we aim to I) provide information about the impact of pituitary disorders on ectopic fat stores, II) and to present up-to-date knowledge on potential pathophysiological mechanisms of hormone action in ectopic lipid metabolism.https://www.frontiersin.org/articles/10.3389/fendo.2023.1075776/fullectopic fatHPA - hypothalamic-pituitary-adrenalgrowth hormonehypogonadismthyroid hormoneNAFLD |
spellingShingle | Clemens Baumgartner Martin Krššák Greisa Vila Michael Krebs Peter Wolf Ectopic lipid metabolism in anterior pituitary dysfunction Frontiers in Endocrinology ectopic fat HPA - hypothalamic-pituitary-adrenal growth hormone hypogonadism thyroid hormone NAFLD |
title | Ectopic lipid metabolism in anterior pituitary dysfunction |
title_full | Ectopic lipid metabolism in anterior pituitary dysfunction |
title_fullStr | Ectopic lipid metabolism in anterior pituitary dysfunction |
title_full_unstemmed | Ectopic lipid metabolism in anterior pituitary dysfunction |
title_short | Ectopic lipid metabolism in anterior pituitary dysfunction |
title_sort | ectopic lipid metabolism in anterior pituitary dysfunction |
topic | ectopic fat HPA - hypothalamic-pituitary-adrenal growth hormone hypogonadism thyroid hormone NAFLD |
url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1075776/full |
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