Advances in Lung Cancer Driver Genes Associated With Brain Metastasis
Brain metastasis, one of the common complications of lung cancer, is an important cause of death in patients with advanced cancer, despite progress in treatment strategies. Lung cancers with positive driver genes have higher incidence and risk of brain metastases, suggesting that driver events assoc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.606300/full |
| _version_ | 1818595119900655616 |
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| author | Yalin Kang Yu Jin Qianxia Li Xianglin Yuan |
| author_facet | Yalin Kang Yu Jin Qianxia Li Xianglin Yuan |
| author_sort | Yalin Kang |
| collection | DOAJ |
| description | Brain metastasis, one of the common complications of lung cancer, is an important cause of death in patients with advanced cancer, despite progress in treatment strategies. Lung cancers with positive driver genes have higher incidence and risk of brain metastases, suggesting that driver events associated with these genes might be biomarkers to detect and prevent disease progression. Common lung cancer driver genes mainly encode receptor tyrosine kinases (RTKs), which are important internal signal molecules that interact with external signals. RTKs and their downstream signal pathways are crucial for tumor cell survival, invasion, and colonization in the brain. In addition, new tumor driver genes, which also encode important molecules closely related to the RTK signaling pathway, have been found to be closely related to the brain metastases of lung cancer. In this article, we reviewed the relationship between lung cancer driver genes and brain metastasis, and summarized the mechanism of driver gene-associated pathways in brain metastasis. By understanding the molecular characteristics during brain metastasis, we can better stratify lung cancer patients and alert those at high risk of brain metastasis, which helps to promote individual therapy for lung cancer. |
| first_indexed | 2024-12-16T11:10:57Z |
| format | Article |
| id | doaj.art-5de3daff22ab4792847fcd69bfeea369 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-16T11:10:57Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-5de3daff22ab4792847fcd69bfeea3692022-12-21T22:33:44ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-01-011010.3389/fonc.2020.606300606300Advances in Lung Cancer Driver Genes Associated With Brain MetastasisYalin KangYu JinQianxia LiXianglin YuanBrain metastasis, one of the common complications of lung cancer, is an important cause of death in patients with advanced cancer, despite progress in treatment strategies. Lung cancers with positive driver genes have higher incidence and risk of brain metastases, suggesting that driver events associated with these genes might be biomarkers to detect and prevent disease progression. Common lung cancer driver genes mainly encode receptor tyrosine kinases (RTKs), which are important internal signal molecules that interact with external signals. RTKs and their downstream signal pathways are crucial for tumor cell survival, invasion, and colonization in the brain. In addition, new tumor driver genes, which also encode important molecules closely related to the RTK signaling pathway, have been found to be closely related to the brain metastases of lung cancer. In this article, we reviewed the relationship between lung cancer driver genes and brain metastasis, and summarized the mechanism of driver gene-associated pathways in brain metastasis. By understanding the molecular characteristics during brain metastasis, we can better stratify lung cancer patients and alert those at high risk of brain metastasis, which helps to promote individual therapy for lung cancer.https://www.frontiersin.org/articles/10.3389/fonc.2020.606300/fullbrain metastasislung cancerdriver genereceptor tyrosine kinaseepithelial-mesenchymal transitioncolonization |
| spellingShingle | Yalin Kang Yu Jin Qianxia Li Xianglin Yuan Advances in Lung Cancer Driver Genes Associated With Brain Metastasis Frontiers in Oncology brain metastasis lung cancer driver gene receptor tyrosine kinase epithelial-mesenchymal transition colonization |
| title | Advances in Lung Cancer Driver Genes Associated With Brain Metastasis |
| title_full | Advances in Lung Cancer Driver Genes Associated With Brain Metastasis |
| title_fullStr | Advances in Lung Cancer Driver Genes Associated With Brain Metastasis |
| title_full_unstemmed | Advances in Lung Cancer Driver Genes Associated With Brain Metastasis |
| title_short | Advances in Lung Cancer Driver Genes Associated With Brain Metastasis |
| title_sort | advances in lung cancer driver genes associated with brain metastasis |
| topic | brain metastasis lung cancer driver gene receptor tyrosine kinase epithelial-mesenchymal transition colonization |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.606300/full |
| work_keys_str_mv | AT yalinkang advancesinlungcancerdrivergenesassociatedwithbrainmetastasis AT yujin advancesinlungcancerdrivergenesassociatedwithbrainmetastasis AT qianxiali advancesinlungcancerdrivergenesassociatedwithbrainmetastasis AT xianglinyuan advancesinlungcancerdrivergenesassociatedwithbrainmetastasis |