CD6, a Rheostat-Type Signalosome That Tunes T Cell Activation

CD6, a Rheostat-Type Signalosome That Tunes T Cell Activation

Following T cell receptor triggering, T cell activation is initiated and amplified by the assembly at the TCR/CD3 macrocomplex of a multitude of stimulatory enzymes that activate several signaling cascades. The potency of signaling is, however, modulated by various inhibitory components already at t...

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Bibliographic Details
Main Authors: Carine M. Gonçalves, Sónia N. Henriques, Rita F. Santos, Alexandre M. Carmo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
inhibitory receptors
CD5
CD6
signalosome
T lymphocytes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02994/full

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