Liver and kidney histopathological test of mice received Pauh Kijang (Irvingia malayana Oliv ex A. Benn) extract
The background of this study was to determine the safety of pauh kijang extract which is orally given to mice while the aim of the study was to evaluate the liver and kidney histopathological changes after receiving various dose of the extract mango (Irvingia malayana Oliv. Exe Benth.) ethanol e...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2008-10-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/314 |
| _version_ | 1828857704626520064 |
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| author | Dewi Ratih Agungpriyono Esti Rahayu Praptiwi |
| author_facet | Dewi Ratih Agungpriyono Esti Rahayu Praptiwi |
| author_sort | Dewi Ratih Agungpriyono |
| collection | DOAJ |
| description | The background of this study was to determine the safety of pauh kijang
extract which is orally given to mice while the aim of the study was to
evaluate the liver and kidney histopathological changes after receiving
various dose of the extract mango (Irvingia malayana Oliv. Exe Benth.)
ethanol extract. There were five group of treatments in this study : mice
received extract with the concentration of (I) 1000mg /kg BW, (II)100 mg/kg
BW, (III) 10 mg/kg BW, (IV) 1 mg/kg BW, and (V) received carboxy methyl
cellulose-sodium (CMC-Na) as negative control. Each treatment consisted of
five mice. After seven days of treatment, mice were sacrified. The liver and
kidney were sampled and processed to prepare histopathology slides. The
histopathology parameters were examined by counting the degeneration and
necrotic cells of hepatocytes and renal epithelial tubule. The lesion of
glomerulus such as atrophy and protein sedimentation were also observed.
The result also showed that extract concentration of > 10 mg/kg BW result in
damaging liver cells significantly, while kidney cell damage occurred
significantly in the exposure of extract > 1 mg/kg BW. |
| first_indexed | 2024-12-13T01:42:00Z |
| format | Article |
| id | doaj.art-5de6ce8ba75b4022ab36951aa38ec983 |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-13T01:42:00Z |
| publishDate | 2008-10-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-5de6ce8ba75b4022ab36951aa38ec9832022-12-22T00:03:44ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862008-10-01194172177http://dx.doi.org/10.14499/indonesianjpharm0iss0pp172-177Liver and kidney histopathological test of mice received Pauh Kijang (Irvingia malayana Oliv ex A. Benn) extractDewi Ratih Agungpriyono0Esti Rahayu 1 Praptiwi2Fakultas Kedokteran Hewan, Institut Pertanian BogorFakultas Kedokteran Hewan, Institut Pertanian BogorPuslit Biologi-LIPI The background of this study was to determine the safety of pauh kijang extract which is orally given to mice while the aim of the study was to evaluate the liver and kidney histopathological changes after receiving various dose of the extract mango (Irvingia malayana Oliv. Exe Benth.) ethanol extract. There were five group of treatments in this study : mice received extract with the concentration of (I) 1000mg /kg BW, (II)100 mg/kg BW, (III) 10 mg/kg BW, (IV) 1 mg/kg BW, and (V) received carboxy methyl cellulose-sodium (CMC-Na) as negative control. Each treatment consisted of five mice. After seven days of treatment, mice were sacrified. The liver and kidney were sampled and processed to prepare histopathology slides. The histopathology parameters were examined by counting the degeneration and necrotic cells of hepatocytes and renal epithelial tubule. The lesion of glomerulus such as atrophy and protein sedimentation were also observed. The result also showed that extract concentration of > 10 mg/kg BW result in damaging liver cells significantly, while kidney cell damage occurred significantly in the exposure of extract > 1 mg/kg BW.http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/314Irvingia malayanaliverkidney |
| spellingShingle | Dewi Ratih Agungpriyono Esti Rahayu Praptiwi Liver and kidney histopathological test of mice received Pauh Kijang (Irvingia malayana Oliv ex A. Benn) extract Indonesian Journal of Pharmacy Irvingia malayana liver kidney |
| title | Liver and kidney histopathological test of mice received Pauh Kijang (Irvingia malayana Oliv ex A. Benn) extract |
| title_full | Liver and kidney histopathological test of mice received Pauh Kijang (Irvingia malayana Oliv ex A. Benn) extract |
| title_fullStr | Liver and kidney histopathological test of mice received Pauh Kijang (Irvingia malayana Oliv ex A. Benn) extract |
| title_full_unstemmed | Liver and kidney histopathological test of mice received Pauh Kijang (Irvingia malayana Oliv ex A. Benn) extract |
| title_short | Liver and kidney histopathological test of mice received Pauh Kijang (Irvingia malayana Oliv ex A. Benn) extract |
| title_sort | liver and kidney histopathological test of mice received pauh kijang irvingia malayana oliv ex a benn extract |
| topic | Irvingia malayana liver kidney |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/314 |
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