Lentiviral interferon: A novel method for gene therapy in bladder cancer

Lentiviral interferon: A novel method for gene therapy in bladder cancer

Interferon alpha (IFNα) gene therapy is emerging as a new treatment option for patients with non-muscle invasive bladder cancer (NMIBC). Adenoviral vectors expressing IFNα have shown clinical efficacy treating bacillus Calmette-Guerin (BCG)-unresponsive bladder cancer (BLCA). However, transient tran...

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Bibliographic Details
Main Authors: Sharada Mokkapati, Vikram M. Narayan, Ganiraju C. Manyam, Amy H. Lim, Jonathan J. Duplisea, Andrea Kokorovic, Tanner S. Miest, Anirban P. Mitra, Devin Plote, Selvalakshmi Selvaraj Anand, Michael J. Metcalfe, Kenneth Dunner, Jr., Burles A. Johnson, Bogdan A. Czerniak, Tiina Nieminen, Tommi Heikura, Seppo Yla-Herttuala, Nigel R. Parker, Kimberley S. Schluns, David J. McConkey, Colin P. Dinney
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
interferon alpha
gene therapy
bladder cancer
IL-6
lentiviral vector
intravesical
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522000833

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