COVID vaccination and asthma exacerbation: might there be a link?
ABSTRACT: Introduction: There is ongoing debate regarding the role of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in asthma exacerbation, and its long-term impact on the lung function of individuals with asthma. In contrast, the potential impact of coronavirus disease 201...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971221007335 |
| _version_ | 1830430224663183360 |
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| author | Marta Colaneri Maria De Filippo Amelia Licari Alessia Marseglia Laura Maiocchi Alessandra Ricciardi Angelo Corsico Gianluigi Marseglia Mario Umberto Mondelli Raffaele Bruno |
| author_facet | Marta Colaneri Maria De Filippo Amelia Licari Alessia Marseglia Laura Maiocchi Alessandra Ricciardi Angelo Corsico Gianluigi Marseglia Mario Umberto Mondelli Raffaele Bruno |
| author_sort | Marta Colaneri |
| collection | DOAJ |
| description | ABSTRACT: Introduction: There is ongoing debate regarding the role of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in asthma exacerbation, and its long-term impact on the lung function of individuals with asthma. In contrast, the potential impact of coronavirus disease 2019 (COVID-19) vaccination on asthma is entirely unexplored. Case study: This study examined a challenging case of severe asthma exacerbation in a 28-year-old female following two doses of the mRNA-based vaccine BNT162b2 (Pfizer-BioNTech) at IRCCS Policlinico San Matteo in Pavia, Italy. The patient, a fourth-year resident at the hospital, was vaccinated in early 2021. She was an occasional smoker with a 10-year history of asthma and seasonal allergic rhinitis. She tested negative for SARS-CoV-2 on several molecular swabs and serology tests. Results: After receiving the second dose of vaccine, the patient started to experience worsening of respiratory symptoms. Following several episodes and a severe asthma attack, the patient required treatment with mepolizumab, a biologic drug (interleukin-5) antagonist monoclonal antibody. Conclusion: This single case study is insufficient to draw conclusions about the association between asthma exacerbation and the COVID-19 vaccine. While the cause–effect link between vaccination against SARS-CoV-2 and worsening of asthmatic disease might only be suggested at present, this case is a valuable prompt for further investigation. This is particularly true from the perspective of mass vaccination of adolescents and children currently underway across the globe. |
| first_indexed | 2024-12-21T01:45:23Z |
| format | Article |
| id | doaj.art-5de753d6a4714c3ea67ec1024a75a10d |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-21T01:45:23Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-5de753d6a4714c3ea67ec1024a75a10d2022-12-21T19:20:02ZengElsevierInternational Journal of Infectious Diseases1201-97122021-11-01112243246COVID vaccination and asthma exacerbation: might there be a link?Marta Colaneri0Maria De Filippo1Amelia Licari2Alessia Marseglia3Laura Maiocchi4Alessandra Ricciardi5Angelo Corsico6Gianluigi Marseglia7Mario Umberto Mondelli8Raffaele Bruno9Infectious Diseases I Unit, I.R.C.C.S. Policlinico San Matteo Foundation, Pavia, Italy; Corresponding author. Infectious Diseases I Unit, I.R.C.C.S. Policlinico San Matteo Foundation, Viale Golgi 19, 27100 Pavia, Italy.Paediatric Clinic, I.R.C.C.S. Policlinico San Matteo Foundation, Pavia, ItalyPaediatric Clinic, I.R.C.C.S. Policlinico San Matteo Foundation, Pavia, ItalyPaediatric Clinic, I.R.C.C.S. Policlinico San Matteo Foundation, Pavia, ItalyInfectious Diseases I Unit, I.R.C.C.S. Policlinico San Matteo Foundation, Pavia, ItalyInfectious Diseases I Unit, I.R.C.C.S. Policlinico San Matteo Foundation, Pavia, ItalyDepartment of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy; Chest Medicine Unit, I.R.C.C.S. Policlinico San Matteo Foundation, Pavia, ItalyPaediatric Clinic, I.R.C.C.S. Policlinico San Matteo Foundation, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, ItalyInfectious Diseases I Unit, I.R.C.C.S. Policlinico San Matteo Foundation, Pavia, Italy; Divisions of Infectious Diseases II and Immunology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, ItalyInfectious Diseases I Unit, I.R.C.C.S. Policlinico San Matteo Foundation, Pavia, Italy; Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, ItalyABSTRACT: Introduction: There is ongoing debate regarding the role of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in asthma exacerbation, and its long-term impact on the lung function of individuals with asthma. In contrast, the potential impact of coronavirus disease 2019 (COVID-19) vaccination on asthma is entirely unexplored. Case study: This study examined a challenging case of severe asthma exacerbation in a 28-year-old female following two doses of the mRNA-based vaccine BNT162b2 (Pfizer-BioNTech) at IRCCS Policlinico San Matteo in Pavia, Italy. The patient, a fourth-year resident at the hospital, was vaccinated in early 2021. She was an occasional smoker with a 10-year history of asthma and seasonal allergic rhinitis. She tested negative for SARS-CoV-2 on several molecular swabs and serology tests. Results: After receiving the second dose of vaccine, the patient started to experience worsening of respiratory symptoms. Following several episodes and a severe asthma attack, the patient required treatment with mepolizumab, a biologic drug (interleukin-5) antagonist monoclonal antibody. Conclusion: This single case study is insufficient to draw conclusions about the association between asthma exacerbation and the COVID-19 vaccine. While the cause–effect link between vaccination against SARS-CoV-2 and worsening of asthmatic disease might only be suggested at present, this case is a valuable prompt for further investigation. This is particularly true from the perspective of mass vaccination of adolescents and children currently underway across the globe.http://www.sciencedirect.com/science/article/pii/S1201971221007335SARS-CoV-2Asthma exacerbationMonoclonal antibody against interleukin-5COVID-19 vaccinationLong COVIDMass vaccination |
| spellingShingle | Marta Colaneri Maria De Filippo Amelia Licari Alessia Marseglia Laura Maiocchi Alessandra Ricciardi Angelo Corsico Gianluigi Marseglia Mario Umberto Mondelli Raffaele Bruno COVID vaccination and asthma exacerbation: might there be a link? International Journal of Infectious Diseases SARS-CoV-2 Asthma exacerbation Monoclonal antibody against interleukin-5 COVID-19 vaccination Long COVID Mass vaccination |
| title | COVID vaccination and asthma exacerbation: might there be a link? |
| title_full | COVID vaccination and asthma exacerbation: might there be a link? |
| title_fullStr | COVID vaccination and asthma exacerbation: might there be a link? |
| title_full_unstemmed | COVID vaccination and asthma exacerbation: might there be a link? |
| title_short | COVID vaccination and asthma exacerbation: might there be a link? |
| title_sort | covid vaccination and asthma exacerbation might there be a link |
| topic | SARS-CoV-2 Asthma exacerbation Monoclonal antibody against interleukin-5 COVID-19 vaccination Long COVID Mass vaccination |
| url | http://www.sciencedirect.com/science/article/pii/S1201971221007335 |
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