A Clot Waveform Analysis of Thrombin Time Using a Small Amount of Thrombin Is Useful for Evaluating the Clotting Activity of Plasma Independent of the Presence of Emicizumab

A Clot Waveform Analysis of Thrombin Time Using a Small Amount of Thrombin Is Useful for Evaluating the Clotting Activity of Plasma Independent of the Presence of Emicizumab

Objective: Although emicizumab is a bispecific, monoclonal antibody that has led to a significant improvement of treatment for hemophilia A patients with inhibitors, the routine monitoring of patients treated with emicizumab is difficult. Thrombin time (TT) reflects thrombin burst, which mainly depe...

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Bibliographic Details
Main Authors: Hideo Wada, Katsuya Shiraki, Takeshi Matsumoto, Kei Suzuki, Yoshiki Yamashita, Isao Tawara, Hideto Shimpo, Motomu Shimaoka
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Journal of Clinical Medicine
Subjects:
CWA-APTT
CWA-TT
emicizumab
FVIII activity
monitoring
thrombin burst
Online Access:https://www.mdpi.com/2077-0383/11/20/6142

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