Primary Tumor Resection Improves Survival for EGFR-TKI-Treated Patients With Occult M1a Lung Adenocarcinoma
BackgroundThe role of primary tumor resection in occult M1a lung adenocarcinoma remains unclear, especially for patients receiving targeted therapy. The purpose of this study is to assess the effect of primary tumor resection on overall survival (OS) in lung adenocarcinoma patients with occult pleur...
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.622723/full |
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| author | Fangqiu Fu Fangqiu Fu Fangqiu Fu Zhexu Wen Zhexu Wen Zhexu Wen Zhendong Gao Zhendong Gao Zhendong Gao Yue Zhao Yue Zhao Yue Zhao Yuan Li Yuan Li Yuan Li Yang Zhang Yang Zhang Yang Zhang Haiquan Chen Haiquan Chen Haiquan Chen |
| author_facet | Fangqiu Fu Fangqiu Fu Fangqiu Fu Zhexu Wen Zhexu Wen Zhexu Wen Zhendong Gao Zhendong Gao Zhendong Gao Yue Zhao Yue Zhao Yue Zhao Yuan Li Yuan Li Yuan Li Yang Zhang Yang Zhang Yang Zhang Haiquan Chen Haiquan Chen Haiquan Chen |
| author_sort | Fangqiu Fu |
| collection | DOAJ |
| description | BackgroundThe role of primary tumor resection in occult M1a lung adenocarcinoma remains unclear, especially for patients receiving targeted therapy. The purpose of this study is to assess the effect of primary tumor resection on overall survival (OS) in lung adenocarcinoma patients with occult pleural disseminations receiving targeted therapy.MethodsLung adenocarcinoma patients with intraoperatively-confirmed occult pleural dissemination (M1a), who hospitalized in the Department of Thoracic Surgery in Fudan Shanghai Cancer Center from May 2008 to December 2017 and received EGFR-TKIs therapy, were enrolled. Log-rank tests were used to compare the survival differences between groups.Results34 patients receiving EGFR-TKIs were enrolled. The majority of them were never smokers (29/34, 85.3%). Among the enrolled patients, 20 (58.8%) patients underwent primary tumor resection, while 14 (41.2%) patients not. There was no distributional difference of baselines between patients undergoing and not undergoing primary tumor resection. Further analyses demonstrated that the patients undergoing primary tumor resection had a prolonged OS compared with those not (log-rank P= 0.042). The 2-year and 5-year OS for patients receiving primary tumor resection and EGFR-TKIs was 90.0% and 60.1%.ConclusionsPrimary tumor resection was associated with improved survival in patients with occult intraoperatively-confirmed M1a adenocarcinoma receiving EGFR-TKIs. |
| first_indexed | 2024-12-14T19:57:05Z |
| format | Article |
| id | doaj.art-5de8ab9cc24240118db2aedcdf4639dd |
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| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T19:57:05Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-5de8ab9cc24240118db2aedcdf4639dd2022-12-21T22:49:16ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-04-011110.3389/fonc.2021.622723622723Primary Tumor Resection Improves Survival for EGFR-TKI-Treated Patients With Occult M1a Lung AdenocarcinomaFangqiu Fu0Fangqiu Fu1Fangqiu Fu2Zhexu Wen3Zhexu Wen4Zhexu Wen5Zhendong Gao6Zhendong Gao7Zhendong Gao8Yue Zhao9Yue Zhao10Yue Zhao11Yuan Li12Yuan Li13Yuan Li14Yang Zhang15Yang Zhang16Yang Zhang17Haiquan Chen18Haiquan Chen19Haiquan Chen20Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, ChinaInstitute of Thoracic Oncology, Fudan University, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, ChinaInstitute of Thoracic Oncology, Fudan University, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, ChinaInstitute of Thoracic Oncology, Fudan University, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, ChinaInstitute of Thoracic Oncology, Fudan University, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaInstitute of Thoracic Oncology, Fudan University, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Pathology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, ChinaInstitute of Thoracic Oncology, Fudan University, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, ChinaInstitute of Thoracic Oncology, Fudan University, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaBackgroundThe role of primary tumor resection in occult M1a lung adenocarcinoma remains unclear, especially for patients receiving targeted therapy. The purpose of this study is to assess the effect of primary tumor resection on overall survival (OS) in lung adenocarcinoma patients with occult pleural disseminations receiving targeted therapy.MethodsLung adenocarcinoma patients with intraoperatively-confirmed occult pleural dissemination (M1a), who hospitalized in the Department of Thoracic Surgery in Fudan Shanghai Cancer Center from May 2008 to December 2017 and received EGFR-TKIs therapy, were enrolled. Log-rank tests were used to compare the survival differences between groups.Results34 patients receiving EGFR-TKIs were enrolled. The majority of them were never smokers (29/34, 85.3%). Among the enrolled patients, 20 (58.8%) patients underwent primary tumor resection, while 14 (41.2%) patients not. There was no distributional difference of baselines between patients undergoing and not undergoing primary tumor resection. Further analyses demonstrated that the patients undergoing primary tumor resection had a prolonged OS compared with those not (log-rank P= 0.042). The 2-year and 5-year OS for patients receiving primary tumor resection and EGFR-TKIs was 90.0% and 60.1%.ConclusionsPrimary tumor resection was associated with improved survival in patients with occult intraoperatively-confirmed M1a adenocarcinoma receiving EGFR-TKIs.https://www.frontiersin.org/articles/10.3389/fonc.2021.622723/fulllung adenocarcinomaM1aprimary tumor resectionEGFR-TKIssurvival |
| spellingShingle | Fangqiu Fu Fangqiu Fu Fangqiu Fu Zhexu Wen Zhexu Wen Zhexu Wen Zhendong Gao Zhendong Gao Zhendong Gao Yue Zhao Yue Zhao Yue Zhao Yuan Li Yuan Li Yuan Li Yang Zhang Yang Zhang Yang Zhang Haiquan Chen Haiquan Chen Haiquan Chen Primary Tumor Resection Improves Survival for EGFR-TKI-Treated Patients With Occult M1a Lung Adenocarcinoma Frontiers in Oncology lung adenocarcinoma M1a primary tumor resection EGFR-TKIs survival |
| title | Primary Tumor Resection Improves Survival for EGFR-TKI-Treated Patients With Occult M1a Lung Adenocarcinoma |
| title_full | Primary Tumor Resection Improves Survival for EGFR-TKI-Treated Patients With Occult M1a Lung Adenocarcinoma |
| title_fullStr | Primary Tumor Resection Improves Survival for EGFR-TKI-Treated Patients With Occult M1a Lung Adenocarcinoma |
| title_full_unstemmed | Primary Tumor Resection Improves Survival for EGFR-TKI-Treated Patients With Occult M1a Lung Adenocarcinoma |
| title_short | Primary Tumor Resection Improves Survival for EGFR-TKI-Treated Patients With Occult M1a Lung Adenocarcinoma |
| title_sort | primary tumor resection improves survival for egfr tki treated patients with occult m1a lung adenocarcinoma |
| topic | lung adenocarcinoma M1a primary tumor resection EGFR-TKIs survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.622723/full |
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