The sFlt-1/PlGF ratio as a predictor for poor pregnancy and neonatal outcomes
Background: Soluble fms-like tyrosine kinase receptor-1 (sFlt-1)/placental growth factor (PlGF) ratio has been studied extensively as a predictive marker for pre-eclampsia. However, its usefulness for predicting neonatal outcomes remains unknown. This study aimed to evaluate the association of sFlt-...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-12-01
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| Series: | Pediatrics and Neonatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957217302863 |
| _version_ | 1811235791773368320 |
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| author | Yu-Shan Chang Chi-Nien Chen Suh-Fang Jeng Yi-Ning Su Chien-Yi Chen Hung-Chieh Chou Po-Nien Tsao Wu-Shiun Hsieh |
| author_facet | Yu-Shan Chang Chi-Nien Chen Suh-Fang Jeng Yi-Ning Su Chien-Yi Chen Hung-Chieh Chou Po-Nien Tsao Wu-Shiun Hsieh |
| author_sort | Yu-Shan Chang |
| collection | DOAJ |
| description | Background: Soluble fms-like tyrosine kinase receptor-1 (sFlt-1)/placental growth factor (PlGF) ratio has been studied extensively as a predictive marker for pre-eclampsia. However, its usefulness for predicting neonatal outcomes remains unknown. This study aimed to evaluate the association of sFlt-1/PlGF ratio with pregnancy outcomes, neonatal morbidities and short-term postnatal growth patterns in pregnant women and their babies. Methods: sFlt-1 and PlGF were measured in women with fetal intrauterine growth retardation (IUGR) or pre-eclampsia during gestational age (GA) of 16â36 weeks. These women were classified into high- and low-ratio groups with a sFlt-1/PlGF cut-off ratio of 85. The maternal and neonatal outcomes were retrospectively reviewed and compared between the two groups. Results: A total of 25 pregnant women were recruited. Thirteen of them had a sFlt-1/PlGF ratio over 85 and twelve had a ratio of less than 85. The median duration from elevation of sFlt-1/PlGF to delivery was 4.5 weeks. Women in the high SFlt-1/PlGF ratio group had higher rates of intrauterine fetal demise (2/13 vs. 0/12) and early termination (1/13 vs. 0/12). The surviving offspring in this group had a higher incidence of preterm birth (GA: 31.4 ± 2.9 weeks vs. 37.3 ± 1.3 weeks, p < 0.001), lower birth weight (1142 ± 472 g vs. 2311 ± 236 g, p < 0.001), higher incidence of respiratory distress syndrome (6/10 vs. 0/12, p = 0.002) and bronchopulmonary dysplasia (4/10 vs. 0/12, p = 0.01). However, the percentile of body weight, height and head circumference at 28 days of age, 56 days of age and the corrected age of 6 months were comparable between groups. Conclusions: High sFlt-1/PlGF ratio in pregnant women is associated with poor pregnancy and neonatal outcomes. Therefore, the monitoring of sFlt-1/PlGF ratio in pregnant women with fetal IUGR and timely management for placenta-associated diseases are recommended. Key Words: fetal growth retardation, pregnancy outcome, placenta growth factor |
| first_indexed | 2024-04-12T11:58:06Z |
| format | Article |
| id | doaj.art-5de987891e5a4e099fbc9f5078601450 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-04-12T11:58:06Z |
| publishDate | 2017-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-5de987891e5a4e099fbc9f50786014502022-12-22T03:33:57ZengElsevierPediatrics and Neonatology1875-95722017-12-01586529533The sFlt-1/PlGF ratio as a predictor for poor pregnancy and neonatal outcomesYu-Shan Chang0Chi-Nien Chen1Suh-Fang Jeng2Yi-Ning Su3Chien-Yi Chen4Hung-Chieh Chou5Po-Nien Tsao6Wu-Shiun Hsieh7Department of Pediatrics, National Taiwan University Children's Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hsinchu Branch, Hsinchu, TaiwanSchool and Graduate Institute of Physical Therapy, National Taiwan University College of Medicine, Taipei, TaiwanDianthus Maternal Fetal Medicine Clinic, Taipei, Taiwan; Department of Obstetrics and Gynecology, School of Medicine, Taipei Medical University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Children's Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Children's Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Children's Hospital and National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Children's Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan; Corresponding author. Department of Pediatrics, Cathay General Hospital, No. 280, Sec. 4, Ren Ai Road, Taipei, Taiwan. Fax: +886 2 23147450.Background: Soluble fms-like tyrosine kinase receptor-1 (sFlt-1)/placental growth factor (PlGF) ratio has been studied extensively as a predictive marker for pre-eclampsia. However, its usefulness for predicting neonatal outcomes remains unknown. This study aimed to evaluate the association of sFlt-1/PlGF ratio with pregnancy outcomes, neonatal morbidities and short-term postnatal growth patterns in pregnant women and their babies. Methods: sFlt-1 and PlGF were measured in women with fetal intrauterine growth retardation (IUGR) or pre-eclampsia during gestational age (GA) of 16â36 weeks. These women were classified into high- and low-ratio groups with a sFlt-1/PlGF cut-off ratio of 85. The maternal and neonatal outcomes were retrospectively reviewed and compared between the two groups. Results: A total of 25 pregnant women were recruited. Thirteen of them had a sFlt-1/PlGF ratio over 85 and twelve had a ratio of less than 85. The median duration from elevation of sFlt-1/PlGF to delivery was 4.5 weeks. Women in the high SFlt-1/PlGF ratio group had higher rates of intrauterine fetal demise (2/13 vs. 0/12) and early termination (1/13 vs. 0/12). The surviving offspring in this group had a higher incidence of preterm birth (GA: 31.4 ± 2.9 weeks vs. 37.3 ± 1.3 weeks, p < 0.001), lower birth weight (1142 ± 472 g vs. 2311 ± 236 g, p < 0.001), higher incidence of respiratory distress syndrome (6/10 vs. 0/12, p = 0.002) and bronchopulmonary dysplasia (4/10 vs. 0/12, p = 0.01). However, the percentile of body weight, height and head circumference at 28 days of age, 56 days of age and the corrected age of 6 months were comparable between groups. Conclusions: High sFlt-1/PlGF ratio in pregnant women is associated with poor pregnancy and neonatal outcomes. Therefore, the monitoring of sFlt-1/PlGF ratio in pregnant women with fetal IUGR and timely management for placenta-associated diseases are recommended. Key Words: fetal growth retardation, pregnancy outcome, placenta growth factorhttp://www.sciencedirect.com/science/article/pii/S1875957217302863 |
| spellingShingle | Yu-Shan Chang Chi-Nien Chen Suh-Fang Jeng Yi-Ning Su Chien-Yi Chen Hung-Chieh Chou Po-Nien Tsao Wu-Shiun Hsieh The sFlt-1/PlGF ratio as a predictor for poor pregnancy and neonatal outcomes Pediatrics and Neonatology |
| title | The sFlt-1/PlGF ratio as a predictor for poor pregnancy and neonatal outcomes |
| title_full | The sFlt-1/PlGF ratio as a predictor for poor pregnancy and neonatal outcomes |
| title_fullStr | The sFlt-1/PlGF ratio as a predictor for poor pregnancy and neonatal outcomes |
| title_full_unstemmed | The sFlt-1/PlGF ratio as a predictor for poor pregnancy and neonatal outcomes |
| title_short | The sFlt-1/PlGF ratio as a predictor for poor pregnancy and neonatal outcomes |
| title_sort | sflt 1 plgf ratio as a predictor for poor pregnancy and neonatal outcomes |
| url | http://www.sciencedirect.com/science/article/pii/S1875957217302863 |
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