The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population
Abstract Background Atrial fibrillation (AF) is one of the common arrhythmia in clinics. Its incidence is high among the elderly. This study aimed to identify a possible connection between ion channel‐related gene polymorphisms and the risk of AF. Methods A total of 381 patients with coronary heart...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-08-01
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| Series: | Molecular Genetics & Genomic Medicine |
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| Online Access: | https://doi.org/10.1002/mgg3.835 |
| _version_ | 1798016744684519424 |
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| author | Xiumin Liu Yujie Li Huan Zhang Yuqiang Ji Zhao Zhao Changyu Wang |
| author_facet | Xiumin Liu Yujie Li Huan Zhang Yuqiang Ji Zhao Zhao Changyu Wang |
| author_sort | Xiumin Liu |
| collection | DOAJ |
| description | Abstract Background Atrial fibrillation (AF) is one of the common arrhythmia in clinics. Its incidence is high among the elderly. This study aimed to identify a possible connection between ion channel‐related gene polymorphisms and the risk of AF. Methods A total of 381 patients with coronary heart disease were recruited. Based on complete cardiac examination, the patients were divided into two subgroups: 185 patients with AF and 196 patients without AF. An association analysis was performed using 13 genotyped SNPs. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by conditional logistic regression. Results In our research, we found that KCNE2 rs8134775 was associated with a decreased AF risk in the allele model (OR = 0.70; 95% CI: 0.50–0.97; p = 0.034). Genetic model analysis shown that the minor allele T of GJA5 rs35594137 was associated with a decreased AF risk under the recessive model (OR = 0.40; 95% CI: 0.19–0.86; p = 0.018) and the minor allele G of KCNJ2 rs8079702 was associated with an increased AF risk in the recessive model (OR = 2.31; 95% CI: 1.20–4.42; p = 0.012). Conclusions Our results suggest that KCNE2, KCNJ2, and GJA5 influence the development of AF. |
| first_indexed | 2024-04-11T15:55:41Z |
| format | Article |
| id | doaj.art-5de9c62535184b2f93c917c224a60743 |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-04-11T15:55:41Z |
| publishDate | 2019-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-5de9c62535184b2f93c917c224a607432022-12-22T04:15:11ZengWileyMolecular Genetics & Genomic Medicine2324-92692019-08-0178n/an/a10.1002/mgg3.835The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han populationXiumin Liu0Yujie Li1Huan Zhang2Yuqiang Ji3Zhao Zhao4Changyu Wang5Department of Cardiovascular Medicine the Affiliated Hospital of Northwest University & Xi’an No.3 Hospital Xi’an Shaanxi ChinaDepartment of Cardiovascular Medicine First hospital of Xi’an Xi’an Shaanxi ChinaDepartment of Cardiovascular Medicine the Affiliated Hospital of Northwest University & Xi’an No.3 Hospital Xi’an Shaanxi ChinaDepartment of Cardiovascular Medicine First hospital of Xi’an Xi’an Shaanxi ChinaDepartment of Cardiovascular Medicine First Affiliated Hospital of Xi'an Jiaotong University Xi’an Shaanxi ChinaDepartment of Cardiovascular Medicine the Affiliated Hospital of Northwest University & Xi’an No.3 Hospital Xi’an Shaanxi ChinaAbstract Background Atrial fibrillation (AF) is one of the common arrhythmia in clinics. Its incidence is high among the elderly. This study aimed to identify a possible connection between ion channel‐related gene polymorphisms and the risk of AF. Methods A total of 381 patients with coronary heart disease were recruited. Based on complete cardiac examination, the patients were divided into two subgroups: 185 patients with AF and 196 patients without AF. An association analysis was performed using 13 genotyped SNPs. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by conditional logistic regression. Results In our research, we found that KCNE2 rs8134775 was associated with a decreased AF risk in the allele model (OR = 0.70; 95% CI: 0.50–0.97; p = 0.034). Genetic model analysis shown that the minor allele T of GJA5 rs35594137 was associated with a decreased AF risk under the recessive model (OR = 0.40; 95% CI: 0.19–0.86; p = 0.018) and the minor allele G of KCNJ2 rs8079702 was associated with an increased AF risk in the recessive model (OR = 2.31; 95% CI: 1.20–4.42; p = 0.012). Conclusions Our results suggest that KCNE2, KCNJ2, and GJA5 influence the development of AF.https://doi.org/10.1002/mgg3.835atrial fibrillation (AF)case–control studysingle nucleotide polymorphism (SNP) |
| spellingShingle | Xiumin Liu Yujie Li Huan Zhang Yuqiang Ji Zhao Zhao Changyu Wang The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population Molecular Genetics & Genomic Medicine atrial fibrillation (AF) case–control study single nucleotide polymorphism (SNP) |
| title | The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population |
| title_full | The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population |
| title_fullStr | The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population |
| title_full_unstemmed | The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population |
| title_short | The research of ion channel‐related gene polymorphisms with atrial fibrillation in the Chinese Han population |
| title_sort | research of ion channel related gene polymorphisms with atrial fibrillation in the chinese han population |
| topic | atrial fibrillation (AF) case–control study single nucleotide polymorphism (SNP) |
| url | https://doi.org/10.1002/mgg3.835 |
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