Degree of COVID-19 severity and mortality in stroke: correlation of clinical and laboratory parameters
Abstract Background Stroke is one of the neurological manifestations of COVID-19, leading to a significant risk of morbidity and mortality. Clinical manifestations and laboratory parameters were investigated to determine mortality predictors in this case. Method The case control study was conducted...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Neuroscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12868-023-00837-w |
| _version_ | 1797355918261747712 |
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| author | Abdul Gofir Irawan Satriotomo Yossy Catarina Budi Nur Syamsah Mawaddah Ar Rochmah Tommy Rachmat Setyawan Adika Mianoki Raymond Aris Nimrod Alvonsius Silalahi Dhite Bayu Nugroho |
| author_facet | Abdul Gofir Irawan Satriotomo Yossy Catarina Budi Nur Syamsah Mawaddah Ar Rochmah Tommy Rachmat Setyawan Adika Mianoki Raymond Aris Nimrod Alvonsius Silalahi Dhite Bayu Nugroho |
| author_sort | Abdul Gofir |
| collection | DOAJ |
| description | Abstract Background Stroke is one of the neurological manifestations of COVID-19, leading to a significant risk of morbidity and mortality. Clinical manifestations and laboratory parameters were investigated to determine mortality predictors in this case. Method The case control study was conducted at Dr. Sardjito General Hospital,Yogyakarta, Indonesia, with data collected between July 2020 and August 2021. All recorded clinical and laboratory data from acute stroke patients with confirmed COVID-19 were collected. Baseline characteristics, bivariate, and multivariate analyses were assessed to determine significant predictors for mortality. Result This study involved 72 subjects with COVID-19 and stroke. The majority experienced ischemic stroke, with hypertension as the most prevalent comorbidity. Notably, 45.8% of subjects (p < 0.05) loss of consciousness and 72.2% of exhibited motor deficits (p < 0.05). Severe degree of COVID-19 was observed in 52.8% of patients, with respiratory distress and death rates of 56.9% and 58.3%. Comparison of surviving and deceased groups highlighted significant differences in various clinical and laboratory characteristics differences. Hazard ratio (HR) analysis identified loss of consciousness (HR = 2.68; p = 0.01), motor deficit (HR = 2.34; p = 0.03), respiratory distress (HR = 81.51; p < 0.001), and monocyte count (HR:1.002; p = 0.04) as significant predictors of mortality. Conclusion Mortality in COVID-19 patients with stroke was significantly associated with loss of consciousness, motor deficit, respiratory distress, and raised monocyte count. The risk of mortality is heightened when multiple factors coexist. |
| first_indexed | 2024-03-08T14:19:03Z |
| format | Article |
| id | doaj.art-5de9dda07b0e45b78717e6cdbbe2f820 |
| institution | Directory Open Access Journal |
| issn | 1471-2202 |
| language | English |
| last_indexed | 2024-03-08T14:19:03Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj.art-5de9dda07b0e45b78717e6cdbbe2f8202024-01-14T12:13:08ZengBMCBMC Neuroscience1471-22022024-01-012511910.1186/s12868-023-00837-wDegree of COVID-19 severity and mortality in stroke: correlation of clinical and laboratory parametersAbdul Gofir0Irawan Satriotomo1Yossy Catarina Budi Nur Syamsah2Mawaddah Ar Rochmah3Tommy Rachmat Setyawan4Adika Mianoki5Raymond Aris Nimrod Alvonsius Silalahi6Dhite Bayu Nugroho7Department of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/ Dr. Sardjito General Hospital, Jalan Farmako Sekip UtaraDepartment Neurology, University of FloridaDepartment of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/ Dr. Sardjito General Hospital, Jalan Farmako Sekip UtaraDepartment of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/ Dr. Sardjito General Hospital, Jalan Farmako Sekip UtaraDepartment of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/ Dr. Sardjito General Hospital, Jalan Farmako Sekip UtaraDepartment of Neurology, Dr. Soeradji Tirtonegoro General HospitalDepartment of Neurology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada/ Dr. Sardjito General Hospital, Jalan Farmako Sekip UtaraDepartment of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah MadaAbstract Background Stroke is one of the neurological manifestations of COVID-19, leading to a significant risk of morbidity and mortality. Clinical manifestations and laboratory parameters were investigated to determine mortality predictors in this case. Method The case control study was conducted at Dr. Sardjito General Hospital,Yogyakarta, Indonesia, with data collected between July 2020 and August 2021. All recorded clinical and laboratory data from acute stroke patients with confirmed COVID-19 were collected. Baseline characteristics, bivariate, and multivariate analyses were assessed to determine significant predictors for mortality. Result This study involved 72 subjects with COVID-19 and stroke. The majority experienced ischemic stroke, with hypertension as the most prevalent comorbidity. Notably, 45.8% of subjects (p < 0.05) loss of consciousness and 72.2% of exhibited motor deficits (p < 0.05). Severe degree of COVID-19 was observed in 52.8% of patients, with respiratory distress and death rates of 56.9% and 58.3%. Comparison of surviving and deceased groups highlighted significant differences in various clinical and laboratory characteristics differences. Hazard ratio (HR) analysis identified loss of consciousness (HR = 2.68; p = 0.01), motor deficit (HR = 2.34; p = 0.03), respiratory distress (HR = 81.51; p < 0.001), and monocyte count (HR:1.002; p = 0.04) as significant predictors of mortality. Conclusion Mortality in COVID-19 patients with stroke was significantly associated with loss of consciousness, motor deficit, respiratory distress, and raised monocyte count. The risk of mortality is heightened when multiple factors coexist.https://doi.org/10.1186/s12868-023-00837-wCOVID-19MortalityStrokePredictors |
| spellingShingle | Abdul Gofir Irawan Satriotomo Yossy Catarina Budi Nur Syamsah Mawaddah Ar Rochmah Tommy Rachmat Setyawan Adika Mianoki Raymond Aris Nimrod Alvonsius Silalahi Dhite Bayu Nugroho Degree of COVID-19 severity and mortality in stroke: correlation of clinical and laboratory parameters BMC Neuroscience COVID-19 Mortality Stroke Predictors |
| title | Degree of COVID-19 severity and mortality in stroke: correlation of clinical and laboratory parameters |
| title_full | Degree of COVID-19 severity and mortality in stroke: correlation of clinical and laboratory parameters |
| title_fullStr | Degree of COVID-19 severity and mortality in stroke: correlation of clinical and laboratory parameters |
| title_full_unstemmed | Degree of COVID-19 severity and mortality in stroke: correlation of clinical and laboratory parameters |
| title_short | Degree of COVID-19 severity and mortality in stroke: correlation of clinical and laboratory parameters |
| title_sort | degree of covid 19 severity and mortality in stroke correlation of clinical and laboratory parameters |
| topic | COVID-19 Mortality Stroke Predictors |
| url | https://doi.org/10.1186/s12868-023-00837-w |
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