Synthesis, characterization and biological activities of novel Schiff base ligand and its Co(II) and Mn(II) complexes
Azomethine, as an active biological component, has a broad scope of pharmacokinetics actions. Metal ions play a vital character in the human anatomy. In the area of biomedical engineering, the significance of metal complexes of Azomethine has been recognized. Herein, (Z)-2-(2-methyl-1-phenylpropylid...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715623004605 |
| _version_ | 1797422635494146048 |
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| author | Anita Priyanka Ghanghas Kavita Poonia |
| author_facet | Anita Priyanka Ghanghas Kavita Poonia |
| author_sort | Anita |
| collection | DOAJ |
| description | Azomethine, as an active biological component, has a broad scope of pharmacokinetics actions. Metal ions play a vital character in the human anatomy. In the area of biomedical engineering, the significance of metal complexes of Azomethine has been recognized. Herein, (Z)-2-(2-methyl-1-phenylpropylidene)hydrazine-1-carbothioamide ligand and its Co(II) and Mn(II) complexes have been synthesized. The synthesized complexes were characterized by physical and spectral characterization techniques such as Nuclear Magnetic Resonance, Fourier Transform Infrared, Mass, X-ray Diffraction. The Schiff ligand and its metal compounds have been evaluated for antimicrobial, antituberculosis, and anticancer activities. Although the azomethine ligand exhibit antimicrobial potency, the metal complexes were proved better antibacterial agents than the ligand, particularly Mn(II) complexes against Staphylococcus aureus (S. aureus). All the synthesized metal compounds revealed fairly good antifungal potency towards Aspergillus fumigatus (A. fumigatus) than Candida albicans (C. albicans). CoCl2 and MnCl2 showed good antituberculosis activity against MtbC-1565, and the complex synthesized by CoCl2 showed good antitumor activity against cervix HeLa cell lines. |
| first_indexed | 2024-03-09T07:35:16Z |
| format | Article |
| id | doaj.art-5deae02908fe4a77b935b44754d94a19 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-03-09T07:35:16Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-5deae02908fe4a77b935b44754d94a192023-12-03T05:41:07ZengElsevierResults in Chemistry2211-71562024-01-017101221Synthesis, characterization and biological activities of novel Schiff base ligand and its Co(II) and Mn(II) complexes Anita0Priyanka Ghanghas1Kavita Poonia2Department of Chemistry, Banasthali Vidyapith, Rajasthan 304022, IndiaDepartment of Chemistry, Banasthali Vidyapith, Rajasthan 304022, IndiaCorresponding author.; Department of Chemistry, Banasthali Vidyapith, Rajasthan 304022, IndiaAzomethine, as an active biological component, has a broad scope of pharmacokinetics actions. Metal ions play a vital character in the human anatomy. In the area of biomedical engineering, the significance of metal complexes of Azomethine has been recognized. Herein, (Z)-2-(2-methyl-1-phenylpropylidene)hydrazine-1-carbothioamide ligand and its Co(II) and Mn(II) complexes have been synthesized. The synthesized complexes were characterized by physical and spectral characterization techniques such as Nuclear Magnetic Resonance, Fourier Transform Infrared, Mass, X-ray Diffraction. The Schiff ligand and its metal compounds have been evaluated for antimicrobial, antituberculosis, and anticancer activities. Although the azomethine ligand exhibit antimicrobial potency, the metal complexes were proved better antibacterial agents than the ligand, particularly Mn(II) complexes against Staphylococcus aureus (S. aureus). All the synthesized metal compounds revealed fairly good antifungal potency towards Aspergillus fumigatus (A. fumigatus) than Candida albicans (C. albicans). CoCl2 and MnCl2 showed good antituberculosis activity against MtbC-1565, and the complex synthesized by CoCl2 showed good antitumor activity against cervix HeLa cell lines.http://www.sciencedirect.com/science/article/pii/S2211715623004605Schiff baseCo(II) and Mn(II) metal complexesSpectral techniquesAzomethineAntimicrobial screeningAntituberculosis |
| spellingShingle | Anita Priyanka Ghanghas Kavita Poonia Synthesis, characterization and biological activities of novel Schiff base ligand and its Co(II) and Mn(II) complexes Results in Chemistry Schiff base Co(II) and Mn(II) metal complexes Spectral techniques Azomethine Antimicrobial screening Antituberculosis |
| title | Synthesis, characterization and biological activities of novel Schiff base ligand and its Co(II) and Mn(II) complexes |
| title_full | Synthesis, characterization and biological activities of novel Schiff base ligand and its Co(II) and Mn(II) complexes |
| title_fullStr | Synthesis, characterization and biological activities of novel Schiff base ligand and its Co(II) and Mn(II) complexes |
| title_full_unstemmed | Synthesis, characterization and biological activities of novel Schiff base ligand and its Co(II) and Mn(II) complexes |
| title_short | Synthesis, characterization and biological activities of novel Schiff base ligand and its Co(II) and Mn(II) complexes |
| title_sort | synthesis characterization and biological activities of novel schiff base ligand and its co ii and mn ii complexes |
| topic | Schiff base Co(II) and Mn(II) metal complexes Spectral techniques Azomethine Antimicrobial screening Antituberculosis |
| url | http://www.sciencedirect.com/science/article/pii/S2211715623004605 |
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