Clinico-morphological and pathogenetic features of glioblastomas, contaminated by herpes simplex virus
The purpose. To study clinico-morphological and pathogenetic features of glioblastomas, contaminated by herpes simplex virus (HSV).Materials and methods. 708 medical records of patients with glioblastoma have been analyzed in the period from 2000 to 2012. Clinical, morphological and patho...
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| Format: | Article |
| Language: | English |
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Romodanov Neurosurgery Institute
2014-09-01
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| Series: | Ukrainian Neurosurgical Journal |
| Online Access: | https://theunj.org/article/view/47485 |
| _version_ | 1797348286200283136 |
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| author | Tatiana Zhukova Arnold Smeyanovich |
| author_facet | Tatiana Zhukova Arnold Smeyanovich |
| author_sort | Tatiana Zhukova |
| collection | DOAJ |
| description |
The purpose. To study clinico-morphological and pathogenetic features of glioblastomas, contaminated by herpes simplex virus (HSV).Materials and methods. 708 medical records of patients with glioblastoma have been analyzed in the period from 2000 to 2012. Clinical, morphological and pathogrenetic features of tumors flow were studied.Results. In patients with glioblastomas, contaminated by HSV, we observed rashes in the nasolabial triangle, in 57% — viral DNA in liquor. In glioblastomas, contaminated by HSV, bcl-2 expression in endothelial cells tripled, in tumor cells — doubled.Conclusions. 1. In some patients with glioblastomas clinical symptoms of herpes infection were observed: rushes on skin, high leucocytes, increased ERS. In liquor of 57% using polymerase chain reaction (CRP) HSV DNA was detected.2. In glioblastomas tissue HSV antigen was detected, expressed by the tumor and vessel wall and also by vessel wall and tumor tissue at the same time, which is accompanied by infiltration of T-lymphocytes.3. At contamination of glioblastomas by HSV bcl-2 expression in endothelial cells tripled, in tumor cells — doubled, in all groups in average.4. Contamination of glioblastomas by HSV has an ambiguous effect on the growth and progression of tumors: in contaminated tumors mitotic activity is reduced, but number and variety of vessels is increased, which is manifested by tumor’s growth acceleration. |
| first_indexed | 2024-03-08T12:03:39Z |
| format | Article |
| id | doaj.art-5dedefa18fce425ab031581d4b06e4ae |
| institution | Directory Open Access Journal |
| issn | 2663-9084 2663-9092 |
| language | English |
| last_indexed | 2024-03-08T12:03:39Z |
| publishDate | 2014-09-01 |
| publisher | Romodanov Neurosurgery Institute |
| record_format | Article |
| series | Ukrainian Neurosurgical Journal |
| spelling | doaj.art-5dedefa18fce425ab031581d4b06e4ae2024-01-23T13:31:38ZengRomodanov Neurosurgery InstituteUkrainian Neurosurgical Journal2663-90842663-90922014-09-013121810.25305/unj.47485Clinico-morphological and pathogenetic features of glioblastomas, contaminated by herpes simplex virusTatiana Zhukova0Arnold Smeyanovich1Laboratory of Clinical Morphology, Republic Scientific-Practical Center of Traumatology and Orthopedics, Minsk, BelarusNeurosurgery Department, Republic Scientific-Practical Center of Neurology and Neurosurgery, Minsk, Belarus The purpose. To study clinico-morphological and pathogenetic features of glioblastomas, contaminated by herpes simplex virus (HSV).Materials and methods. 708 medical records of patients with glioblastoma have been analyzed in the period from 2000 to 2012. Clinical, morphological and pathogrenetic features of tumors flow were studied.Results. In patients with glioblastomas, contaminated by HSV, we observed rashes in the nasolabial triangle, in 57% — viral DNA in liquor. In glioblastomas, contaminated by HSV, bcl-2 expression in endothelial cells tripled, in tumor cells — doubled.Conclusions. 1. In some patients with glioblastomas clinical symptoms of herpes infection were observed: rushes on skin, high leucocytes, increased ERS. In liquor of 57% using polymerase chain reaction (CRP) HSV DNA was detected.2. In glioblastomas tissue HSV antigen was detected, expressed by the tumor and vessel wall and also by vessel wall and tumor tissue at the same time, which is accompanied by infiltration of T-lymphocytes.3. At contamination of glioblastomas by HSV bcl-2 expression in endothelial cells tripled, in tumor cells — doubled, in all groups in average.4. Contamination of glioblastomas by HSV has an ambiguous effect on the growth and progression of tumors: in contaminated tumors mitotic activity is reduced, but number and variety of vessels is increased, which is manifested by tumor’s growth acceleration.https://theunj.org/article/view/47485 |
| spellingShingle | Tatiana Zhukova Arnold Smeyanovich Clinico-morphological and pathogenetic features of glioblastomas, contaminated by herpes simplex virus Ukrainian Neurosurgical Journal |
| title | Clinico-morphological and pathogenetic features of glioblastomas, contaminated by herpes simplex virus |
| title_full | Clinico-morphological and pathogenetic features of glioblastomas, contaminated by herpes simplex virus |
| title_fullStr | Clinico-morphological and pathogenetic features of glioblastomas, contaminated by herpes simplex virus |
| title_full_unstemmed | Clinico-morphological and pathogenetic features of glioblastomas, contaminated by herpes simplex virus |
| title_short | Clinico-morphological and pathogenetic features of glioblastomas, contaminated by herpes simplex virus |
| title_sort | clinico morphological and pathogenetic features of glioblastomas contaminated by herpes simplex virus |
| url | https://theunj.org/article/view/47485 |
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