Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control
The human insular cortex is a heterogeneous brain structure which plays an integrative role in guiding behavior. The cytoarchitectonic organization of the human insula has been investigated over the last century using postmortem brains but there has been little progress in noninvasive in vivo mappin...
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| Format: | Article |
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eLife Sciences Publications Ltd
2020-06-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/53470 |
| _version_ | 1811200358237601792 |
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| author | Vinod Menon Guillermo Gallardo Mark A Pinsk Van-Dang Nguyen Jing-Rebecca Li Weidong Cai Demian Wassermann |
| author_facet | Vinod Menon Guillermo Gallardo Mark A Pinsk Van-Dang Nguyen Jing-Rebecca Li Weidong Cai Demian Wassermann |
| author_sort | Vinod Menon |
| collection | DOAJ |
| description | The human insular cortex is a heterogeneous brain structure which plays an integrative role in guiding behavior. The cytoarchitectonic organization of the human insula has been investigated over the last century using postmortem brains but there has been little progress in noninvasive in vivo mapping of its microstructure and large-scale functional circuitry. Quantitative modeling of multi-shell diffusion MRI data from 413 participants revealed that human insula microstructure differs significantly across subdivisions that serve distinct cognitive and affective functions. Insular microstructural organization was mirrored in its functionally interconnected circuits with the anterior cingulate cortex that anchors the salience network, a system important for adaptive switching of cognitive control systems. Furthermore, insular microstructural features, confirmed in Macaca mulatta, were linked to behavior and predicted individual differences in cognitive control ability. Our findings open new possibilities for probing psychiatric and neurological disorders impacted by insular cortex dysfunction, including autism, schizophrenia, and fronto-temporal dementia. |
| first_indexed | 2024-04-12T02:03:30Z |
| format | Article |
| id | doaj.art-5def701380fe499b99e84cfd839ae192 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:03:30Z |
| publishDate | 2020-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-5def701380fe499b99e84cfd839ae1922022-12-22T03:52:36ZengeLife Sciences Publications LtdeLife2050-084X2020-06-01910.7554/eLife.53470Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive controlVinod Menon0Guillermo Gallardo1https://orcid.org/0000-0002-8271-2516Mark A Pinsk2Van-Dang Nguyen3Jing-Rebecca Li4Weidong Cai5https://orcid.org/0000-0001-9581-7774Demian Wassermann6https://orcid.org/0000-0001-5194-6056Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Stanford, United States; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, Stanford, United States; Stanford Neurosciences Institute, Stanford University School of Medicine, Stanford, Stanford, United StatesAthena, Inria Sophia Antipolis, Université Côte d’Azur, Sophia Antipolis, France; Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, GermanyPrinceton Neuroscience Institute, Princeton University, Princeton, United StatesDepartment of Computational Science and Technology Royal Institute of Technology in Stockholm, Stockholm, SwedenDefi, Inria Saclay Île-de-France, École Polytechnique Université Paris Sud, Palaiseau, FranceDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Stanford, United StatesParietal, Inria Saclay Île-de-France, CEA Université Paris Sud, Palaiseau, FranceThe human insular cortex is a heterogeneous brain structure which plays an integrative role in guiding behavior. The cytoarchitectonic organization of the human insula has been investigated over the last century using postmortem brains but there has been little progress in noninvasive in vivo mapping of its microstructure and large-scale functional circuitry. Quantitative modeling of multi-shell diffusion MRI data from 413 participants revealed that human insula microstructure differs significantly across subdivisions that serve distinct cognitive and affective functions. Insular microstructural organization was mirrored in its functionally interconnected circuits with the anterior cingulate cortex that anchors the salience network, a system important for adaptive switching of cognitive control systems. Furthermore, insular microstructural features, confirmed in Macaca mulatta, were linked to behavior and predicted individual differences in cognitive control ability. Our findings open new possibilities for probing psychiatric and neurological disorders impacted by insular cortex dysfunction, including autism, schizophrenia, and fronto-temporal dementia.https://elifesciences.org/articles/53470diffusion MRIinsulasaliency networkcognitive controlbehaviourneural circuits |
| spellingShingle | Vinod Menon Guillermo Gallardo Mark A Pinsk Van-Dang Nguyen Jing-Rebecca Li Weidong Cai Demian Wassermann Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control eLife diffusion MRI insula saliency network cognitive control behaviour neural circuits |
| title | Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control |
| title_full | Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control |
| title_fullStr | Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control |
| title_full_unstemmed | Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control |
| title_short | Microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control |
| title_sort | microstructural organization of human insula is linked to its macrofunctional circuitry and predicts cognitive control |
| topic | diffusion MRI insula saliency network cognitive control behaviour neural circuits |
| url | https://elifesciences.org/articles/53470 |
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