Epigenetic Modulation of Self-Renewal Capacity of Leukemic Stem Cells and Implications for Chemotherapy

Epigenetic Modulation of Self-Renewal Capacity of Leukemic Stem Cells and Implications for Chemotherapy

Most patients with acute myeloid leukemia (AML) have a poor prognosis. Curative therapy of AML requires<i> </i>the complete eradication of the leukemic stem cells (LSCs). One aspect of LSCs that is poorly understood is their low frequency in the total population of leukemic cells in AML...

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Bibliographic Details
Main Authors: Richard L. Momparler, Sylvie Côté, Louise F. Momparler
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Epigenomes
Subjects:
leukemic stem cells
self-renewal
epigenetics
dna methylation
histone methylation
5-aza-2′-deoxycytidine
3-deazaplanocin-a
Online Access:https://www.mdpi.com/2075-4655/4/1/3

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